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All Journal Majalah Kedokteran Bandung
Rizki, Kiki Ahmad
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Medicine & Pharmacology

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Traumatic Brain Injury and Covid-19 Tinambunan, Nicholas Christian; Faried, Ahmad; Djajakusumah, Teguh Marfen; Yohana, Raden; Rizki, Kiki Ahmad; Sobana, Mirna
Majalah Kedokteran Bandung Vol 56, No 2 (2024)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v56.3229

Abstract

Head trauma is a head injury caused by external forces in the head or body that results in disruption of the normal functioning of the brain. According to the CDC, deaths from head injuries were about 60,000 in 2016, and rose to more than 61,000 in 2017. The COVID-19 pandemic had caused poor non-COVID patient care, especially in low- and lower-middle-income countries with limited access to health facilities, resulting in increased morbidity and mortality, including among patients with head injuries. The purpose of this study was to understand the characteristics, duration of hospital stay, and difference of time to surgery interval in Traumatic Brain Injury patients in Dr. Hasan Sadikin General Hospital Bandung before and during the COVID-19 pandemic. This study was performed through analytical methods with a cross-sectional study design using analysis of medical records of head trauma patients treated in Dr. Hasan Sadikin General Hospital Bandung, Indonesia in the period before the pandemic (February 2018-February 2020) and during the pandemic (March 2020 - September 2021). Data analysis showed significant differences in length of hospitalization and operating intervals before and during the pandemic (p=0.04 and p=0.03), showing that there are differences in interval operation and duration of stay between patients with head trauma before the pandemic and during the pandemic.
Correlation Between Pre-Chemotherapy AMH Level, Menstrual Status, and Prediction of Ovarian Function Recovery after FAC Chemotherapy AMH in Breast Cancer Patients Abdurahman, Maman; Rizki, Kiki Ahmad; Pringadi, Adi Zufron
Majalah Kedokteran Bandung Vol 55, No 3 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n3.3134

Abstract

Around 52.6% of women aged <50 years in Indonesia are diagnosed with breast cancer. One of the chemotherapy regimens with a toxicity effect on reproductive function, especially ovarian follicles, is 5-fluorouracil-doxorubicin-cyclophosphamide (FAC). Anti-Mullerian Hormone (AMH) is a biomarker that can be used to assess the ovarian function. This study aimed to determine the correlation between pre-chemotherapy AMH serum level, menstrual status, and whether the AMH serum level can predict ovarian function recovery in pre-menopausal women receiving FAC chemotherapy. This was an analytical observational study with a prospective cohort design performed in Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, during 2021-2022. Data were analyzed using correlation analysis. Subjects were breast cancer patients aged ≤45 years, still of reproductive age, with no prior history of chemotherapy, and were undergoing the FAC chemotherapy. All 32 patients who met the inclusion criteria were included in this study. There was a significant difference (p 0.0001) between pre- and post-6 cycles of chemotherapy AMH levels. Post-6 cycles of chemotherapy showed lower AMH levels. There was a high correlation (p 0.0034) between pre-chemotherapy AMH level and menstrual status six months after six cycles of chemotherapy. The correlation test between post-chemotherapy AMH level and menstrual status showed a non-significant result. Thus, there is a high statistical correlation between pre-chemotherapy anti-Mullerian hormone levels in pre-menopausal women with breast cancer and the menstrual status after FAC chemotherapy which demonstrates that the AMH level could also be used to predict ovarian function recovery.
Co-Authors Ahmad Faried Maman Abdurahman Pringadi, Adi Zufron Raden Yohana, Raden Sobana, Mirna Teguh Marfen Djajakusumah, Teguh Marfen Tinambunan, Nicholas Christian