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All Journal Diponegoro Law Review Journal of Applied Pharmaceutical Research The South East Asian Journal of Management
Devi, Arti
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Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology

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A review on characteristics and analytical methods of atovaquone – a potent antimalarial agent Sharma, Sanyam; Sharma, Rahul; Devi, Arti; Jindal, Shammy; Goyal, Kamya
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.31.37

Abstract

Drugs used in the treatment of malaria that is caused by various plasmosium species i.e. P. falciparum, P. vivax are most irresistible disease throughout the world. The different medications are utilized in the treatment of malaria incorporated the Aryl aminoalcohol mixes: Quinine, Quinidine, Chloroquine, Mefloquine; Antifolate compound: Pyrimethamine, Proguanil, Chlorproguanil, Trimethoprim and Atovaquone. Atovaquone is most effective drug utilized in the treatment of malaria. It must be given in single or in mixture with different antimalarials. An enormous number of methodologies including High Performance Liquid chromatography (HPLC), UV–Visible spectroscopy and Liquid Chromatography-Mass Spectroscopy (LC-MS) are utilized for the determination of atovaquone. Various analytical methods are used for the analysis of pharmaceutical products and these methods were validated according to ICH guidelines (Q1A R2). Thus, this technique can be safely used for the standard quality control analysis of atovaquone.
Development and validation of novel method for simultaneous estimation of Atovaquone and Mefloquine hydrochloride in bulk drug using RP-HPLC Sharma, Sanyam; Ankalgi, Amar Deep; Sharma, Rahul; Devi, Arti; Jindal, Shammy; Goyal, Kamya
Journal of Applied Pharmaceutical Research Vol. 8 No. 3 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.3.48.54

Abstract

Atovaquone and Mefloquine hydrochloride are well known anti-malarial drugs. Literature survey reveals that there was no method available for the selected drug combination. In this way, here an endeavour has been made to develop simple, precise, fast method for simultaneous estimation of atovaquone and mefloquine hydrochloride in bulk drug by using RP-HPLC method. The method was carried out by using gradient HPLC on C18 column using Shimadzu prominence LC 20 AD and mobile phase comprised of Methanol:ACN:Water in the ratio of 85:7.5:7.5 (pH 2.9 was adjusted with OPA). The method was performed with 10µl injection volume. The UV detection was done at 231nm.The retention times of atovaquone and mefloquine hydrochloride were 7.6 and 2.6 min respectively.  The proposed method was validated according to ICH guidelines. The validation parameters were linearity, accuracy, precision (inter-day, intra-day and repeatability) and robustness etc. Linearity was in the range of 80-120µg/ml for atovaquone and 40-60µg/ml for mefloquine hydrochloride. The percent recoveries of both drugs were 99.99-100% and 92.05-99.09%. This method is suitable for the routine analysis of atovaquone and mefloquine hydrochloride in bulk drugs either individually or in mixture
Analytical method development and validation for simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug by simultaneous equation method Choudhary, Amit; Sinha, Manish; Amar Deep Ankalgi; Goyal, Kamya; Devi, Arti
Journal of Applied Pharmaceutical Research Vol. 8 No. 4 (2020)
Publisher : Creative Pharma Assent

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18231/j.joapr.2020.v.8.i.4.24.32

Abstract

The purpose of the research is to establish a fast, accurate, precise, and low-cost UV-Visible spectrophotometry method for the quantitative simultaneous estimation of mefloquine hydrochloride and artemether in bulk drug. The UV-Visible method employed was a simultaneous equation method. Ethanol was used as a solvent and therefore the absorption maxima (λ max) was found to be 229 nm and 209 nm for mefloquine hydrochloride and artemether. The linearity ranges of both drugs were 1-6 μg/mL and 100 – 350 μg/mL with a regression coefficient r2 ≥ 0.998 respectively. The method was validated for different parameters according to International Conference on Harmonization ICH Q2B guidelines. The average recovery for mefloquine hydrochloride was found to be 100 per cent and artemether 99.3 per cent. The method was also found precise and robust with a per cent relative standard deviation of less than 2. All the parameters result obtained within the limits. Therefore, the proposed method for the accurate quantitation of mefloquine hydrochloride and artemether in the bulk drug was successfully implemented.
Employers’ Perspective Towards People with Disabilities: A Review of The Literature Heera, Sonali; Devi, Arti
The South East Asian Journal of Management Vol. 10, No. 1
Publisher : UI Scholars Hub

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Abstract

The significance of employment for people with disabilities has gained interest among researchers. The successful inclusion of people with disabilities in the employment settings depends on the employers’ perspective towards their integration in the mainstream workforce. This review examines literature over the past 25 years with an attempt to assess the employers’ perspective and specifically, the factors influencing their perspective towards inclusion of people with disabilities in employment. A search of electronic databases has resulted in the selection and analysis of 44 articles. The literature indicates that employers’ perspective plays an important role in providing and maintaining employment opportunities for people with disabilities. A number of factors including type of disability and demographic variables affecting employers’ perspective have been identified and discussed.
CRITIQUING DELEGATED LEGISLATION ON PREVENTING SEXUAL HARASSMENT OF WOMEN IN INDIAN HIGHER EDUCATION INSTITUTIONS Budhiartie, Arrie; Pradhan, David; Devi, Arti
Diponegoro Law Review Vol 9, No 1 (2024): Diponegoro Law Review April 2024
Publisher : Fakultas Hukum, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/dilrev.9.1.2024.136-152

Abstract

Sexual harassment of women in the workplace is a serious issue in India, affecting all social and professional sectors, including elite higher education institutions. This problem violates women's fundamental rights to equality and livelihood, breaches professional ethics, and hampers the productivity and potential of many academics. Although the Indian Parliament enacted a comprehensive law in 2013 to address sexual harassment at workplaces, the implementation, especially in educational institutions, is flawed due to bureaucratic inefficiencies. There is a lack of unbiased analysis on how delegated regulations by administrative authorities undermine the law's intent. This research article conducts a legal analysis of the law's implementation in higher educational institutions, using doctrinal research methodology. It identifies subjective and ultra vires provisions introduced by ideologically driven bureaucrats that compromise the law's validity and effectiveness. The study highlights deviations in delegated legislation from the original law and suggests corrective measures to address significant flaws in the regulations framed by the University Grants Commission.
Co-Authors Amar Deep Ankalgi Ankalgi, Amar Deep Arrie Budhiartie Choudhary, Amit Goyal, Kamya Heera, Sonali Jindal, Shammy Pradhan, David Sharma, Rahul Sharma, Sanyam Sinha, Manish