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All Journal VALENSI Pharmaciana: Jurnal Kefarmasian Farmasains : Jurnal Ilmiah Ilmu Kefarmasian Jurnal Kreativitas PKM Pharmacoscript Lumbung Farmasi : Jurnal Ilmu Kefarmasian Journal of Empowerment Community Jurnal Farmagazine Jurnal Insan Farmasi Indonesia Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Termometer: Jurnal Ilmiah Ilmu Kesehatan Dan Kedokteran Jurnal Mahasiswa Ilmu Kesehatan Jurnal Anestesi: Jurnal Ilmu Kesehatan dan Kedokteran Pharmaceutical Science Journal Prosiding Seminar Nasional Unimus Jurnal Farmasi Galenika
Gina Septiani Agustien
Universitas Perjuangan Tasikmalaya
Agriculture, Biological Sciences & Forestry Humanities Biochemistry, Genetics & Molecular Biology Chemistry Decision Sciences, Operations Research & Management Dentistry Economics, Econometrics & Finance Education Engineering Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Physics Public Health Social Sciences

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PENGARUH VARIASI KONSENSTRASI CROSCARMELLOSE SODIUM TERHADAP SIFAT FISIK FAST DISINTEGRATING TABLET EKSTRAK ETANOL BIJI KAPULAGA (Amomum compactum Soland. ex Maton) SEBAGAI SUPERDISINTEGRAN Nofriyaldi, Ali; Septiani Agustien, Gina
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 6 No. 3 (2020)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (563.009 KB) | DOI: 10.22487/htj.v6i3.149

Abstract

Secara Empiris Kapulaga (Amomum compactum Soland. ex Maton) dimanfaatkan oleh masyarakat sebagai antihiperurisemia. Obat antihiperurisemia yang ada dipasaran berbentuk tablet konvensional dan digunakan oleh pasien usia lanjut yang mengalami kesulitan dalam menelan tablet sehingga diformulasikan dalam bentuk sediaan alternative yaitu Fast Disintegrating Tablet (FDT) yang merupakan tablet cepat hancur di mulut. Penelitian ini bertujuan untuk memformulasikan FDT ekstrak etanol biji kapulaga dengan variasi konsentrasi Croscarmellose sodium sebagai superdisintegran. Pembuatan FDT ini menggunakan metode granulasi basah dengan 4 formula yang berbeda dari variasi konsentrasi superdisintegran Croscarmellose sodium 2% (FI), 4% (FII), 6% (FIII), 8% (FIV). Selanjutnya FDT dievaluasi meliputi keseragaman bobot, keseragaman ukuran, kerapuhan, keregasan, dan waktu hancur. Hasil penelitian menunjukan bahwa FIII dengan konsentrasi 4% merupakan formula terbaik dilihat dari uji waktu hancur dibandingkan formula lain.
PENGARUH METODE MASERASI DAN SOKLETASI TERHADAP STABILITAS FISIK SEDIAAN HAIR TONIC EKSTRAK ETANOL DAUN LIDAH MERTUA (Sansevieria trifasciata P.) Agustien, Gina Septiani; Susanti, Susanti
Healthy Tadulako Journal (Jurnal Kesehatan Tadulako) Vol. 8 No. 1 (2022)
Publisher : Universitas Tadulako

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (751.236 KB) | DOI: 10.22487/htj.v8i1.453

Abstract

Hair loss is a disorder in which the amount of hair decreases or falls out more than usual without visible thinning. Hair care requires a variety of cosmetic products such as hair conditioner, cream bath and hair tonic. Hair tonic has several advantages in optimizing efforts to prevent hair loss compared to other hair treatments. Sansevieria leaves (Sansevieria trifasciata) is a plant known as an ornamental plant. Almost all parts of the sansevieria leaves can be used, but not many know that the sansevieria leaves can be used as a hair tonic to treat hair loss. The purpose of this study was to determine the effect of maceration and soxhletation methods on the physical stability of hair tonic preparations of sansevieria leaves extract with varying concentrations of 1%, 3% and 6%. Evaluation of the preparation includes organoleptic, pH, specific gravity and viscosity tests. Physical stability tests were carried out at low temperatures (4oC) and high temperatures (40oC). The test results showed (p-value <0.05) there was no effect between maceration and soxhletation methods on the physical stability of the hair tonic preparation of sansevieria leaves extract. Keywords: Hair Tonic, Sansevieria Leaves, Maceration, Soxhletation, Physical Stability.
The Active Compound of Bangle Essential Oil as Cyclooxygenase-2 (Cox-2) Inhibitor: In Silico Approach Richa Mardianingrum; Ruswanto Ruswanto; Gina Septiani Agustien; Aas Nuraisah
Jurnal Kimia Valensi Jurnal Kimia VALENSI Volume 6, No. 2, November 2020
Publisher : Syarif Hidayatullah State Islamic University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15408/jkv.v6i2.16943

Abstract

Fever is a condition where the body temperature rises above normal or more than 37o C and also tend to be an initial clinical manifestation of the use of antipyretic drugs thatcause toxicity such as on the liver due to prolonged usage. Particularly, the bangle (Zingiber purpureum Roxb.) is one of the Zingiberaceae plants that contain essential oils used for the treatment of fever. Therefore, this researchaimed to identify active compounds which have antipyreticspotential with the in silico approach. The simulation of molecular docking showed 1,4-naphthalenedione-2-ethyl-3-hydroxy was able to attach to the binding site of cyclooxygenase-2 (COX-2) and interact withmain residues that constituted the active cavity of COX-2. While the simulation of molecular dynamics suggested thatthe bound compound was stable at 4 ns, that is the time taken. The binding free energiesexpected by the MM-PBSA method indicated the 1,4-naphthalenedione-2-ethyl-3-hydroxy had a higher affinity than a native ligand (2-[(2,6-dichloro-3-methyl-phenyl)-amino] benzoic acid, JMS) and paracetamol. This suggested its capacity for advancing as a new COX-2 inhibitor.
UJI AKTIVITAS PERTUMBUHAN RAMBUT KOMBINASI EKSTRAK ETANOL DAUN PANDAN WANGI (Pandanus amaryllifolius Roxb.) DAN DAUN LIDAH MERTUA (Sansevieria trifasciata Prain.) Gina Septiani Agustien
Pharmacoscript Vol. 1 No. 2 (2018): Pharmacoscript
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat, Universitas Perjuangan Tasikmalaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36423/pharmacoscript.v1i2.103

Abstract

ABSTRACT The frequency and quantity of hair loss problems increases which eventually leads to baldness. The use of medicinal plants today is very popular and increasingly favored by the community. Plants are efficacious as a hair grower such as pandanus leaves (Pandanus amaryllifolius Roxb.) and sansevieria leaves (Sansevieria trifasciata Prain.). The purpose of this study to determine the hair growth activity of a combination of pandanus leaves extract and sansevieria leaves. Test preparation was made by combining both extracts at 5% concentration with comparison of pandanus leaves extract and sansevieria leaves 1: 1, 2: 3 and 3: 2. The results showed that the combination of 3: 2 has the best hair growth activity. Testing of this hair growth activity is a combination extract compared to normal control, 96% ethanol and minoxidil. The result of hair growth activity showed that the combination extract had better activity than the sole extract. Key word : hair growth activity, pandanus leaves, sansevieria leaves, extract combination.
UJI AKTIVITAS TONIKUM INFUSA BUAH KAPOLAGA (Amomum cardamomum) PADA MENCIT (Mus musculus) Gina Septiani Agustien; Susanti Susanti
Jurnal Farmagazine Vol 7, No 1 (2020): Jurnal Farmagazine
Publisher : STF Muhammadiyah Tangerang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47653/farm.v7i1.152

Abstract

Kebutuhan suplemen penambah stamina atau tonikum bisa didapatkan dari mengkonsumsi tanaman herbal. Pemanfaatan tanaman herbal untuk tonikum mempunyai kelebihan tersendiri dibandingkan senyawa sintetik. Buah kapolaga (Amomum cardamomum) adalah tanaman perdu banyak terdapat di wilayah Indonesia, masyarakat biasanya menggunakan kapolaga untuk bumbu masakan. Buah kapolaga memiliki potensi besar dalam bidang farmasi, yaitu adanya senyawa flavonoid yang bermanfaat sebagai tonikum. Tujuan penelitian adalah untuk mengetahui mengetahui efek tonikum pada mencit dan menentukan pada konsentrasi berapa dapat memberikan efek tonikum yang optimum. Uji efek tonikum dilakukan menggunakan uji renang kemudian dilihat waktu pada petahanan berenang mencit. Metode uji renang yang digunakan adalah natatory exhaustion. Hasil penelitian ini menunjukkan bahwa infusa buah kapolaga pada dosis 2,5 g/kgBB, 5,0 g/kgBB dan 10 g/kgBB pada metode ketahanan berenang menunjukkan efek tonikum pada mencit (Mus musculus). Infusa buah kapolaga pada konsentrasi 10 g/kgBB menunjukkan efek tonikum yang paling baik pada mencit, tetapi efeknya masih lebih kecil daripada pemberian kafein sebagai pembanding. Kata Kunci: Buah Kapolaga, Infusa, Mencit, Tonikum
Pelatihan Pembuatan Serbuk Jamu Pegagan Di Desa Pagersari, Kecamatan Pagerageung, Kabupaten Tasikmalaya Nitya Nurul Fadilah; Richa Mardianingrum; Gina Septiani Agustien
JURNAL KREATIVITAS PENGABDIAN KEPADA MASYARAKAT (PKM) Volume 3 Nomor 2 Oktober 2020
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v3i2.3354

Abstract

Serbuk jamu pegagan memiliki banyak manfaat diantaranya memperlancar peredaran darah, mengatasi gangguan pencernaan, antibakteri, dan untuk kecantikan kulit. Pegagan banyak ditemui di pekarangan rumah atau pinggir sawah khususnya di Desa Pagersari, Kecamatan Ciawi, Kabupaten Tasikmalaya. Tujuan dari program pengabdian masyarakat ini adalah untuk meningkatkan pengetahuan masyarakat tentang cara membuat serbuk jamu yang baik dan bermutu sehingga dapat dijadikan serbuk jamu baik untuk konsumsi sendiri atau untuk diperjualbelikan. Metode yang digunakan adalah berupa pemberian materi dan pelatihan yang terdiri dari proses pembuatan jamu, sortasi kering, pencucian, perajangan, pengeringan dan pengemasan. Serbuk jamu pegagan dapat dikemas dalam bentuk yang menarik, atau membuat masker dengan bahan tambahan lain yang diramu sebagai masker kecantikan. Oleh karena itu, potensi pegagan sebagai produk kesehatan perlu disosialisasikan kepada masyarakat sekitar untuk meningkatkan perekonomian dan pemanfaatan sumber daya alam di daerah melalui masyarakat PKK pada 17 Juli 2020. Hasil dari kegiatan tersebut, masyarakat lebih memahami arti penting dari tanaman di sekitarnya sehingga bisa dijadikan produk kesehatan. Hal tersebut terlihat dari antusiasme masyarakat terhadap pemberian materi dan masyarakat bisa membuat serbuk jamu secara mandiri setelah dilakukan pelatihan. Kata kunci: Pegagan, Jamu, Pagerageung  ABSTRACTPegagan herbal powder, has many benefits including improving blood circulation, overcoming digestive disorders, antibacterial, and for skin. Pegagan is often found in the yard or the edge of rice fields, especially in Pagersari Village, Ciawi District, Tasikmalaya. The purpose of this community service program was to increase public knowledge about how to make good and quality herbal powder so that it can be used as herbal powder either for own consumption or for sale. The method used was in the form of material provision and training which consisted of the process of making herbal medicine, dry sortation, washing, chopping, drying and packaging. The powder of pegagan can be packaged in an attractive form, or herb masks with other additives which are mixed as beauty masks. Therefore, the potential of pegagan as a health product needs to be disseminated to the surrounding community to improve the economy and utilization of natural resources in the area through the PKK community on July 17, 2020. The results of these activities, the community colud understands the importance of the surrounding plants so that they can be used as products health. This could be seen from the enthusiasm of the community for providing materials and the community being able to personally made herbal medicine powder after this training.Keywords: Pegagan, Herb, Pagerageung
Pelatihan Pembuatan Produk Teh Pegagan untuk P-IRT di Desa Pagersari, Kecamatan Pagerageung, Kabupaten Tasikmalaya Nitya Nurul Fadilah; Richa Mardianingrum; Gina Septiani Agustien
Jurnal Kreativitas Pengabdian Kepada Masyarakat (PKM) Vol 5, No 4 (2022): Volume 5 No 4 April 2022
Publisher : Universitas Malahayati Lampung

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33024/jkpm.v5i4.5527

Abstract

ABSTRAK Pemanfaatan tumbuhan sebagai alternatif pengobatan banyak ditemukan di masyarakat desa. Salah satunya Desa Pagersari yang merupakan salah satu desa di Kecamatan Pagerageung, Kabupaten Tasikmalaya. Desa ini terletak di bagian utara Tasikmalaya. Sebagian besar mata pencaharian penduduk di sana merupakan petani, sehingga lingkungannya masih relatif dikelilingi oleh pesawahan yang sebagian besar lahannya dipakai untuk padi, palawija, sayuran dan tanaman lainnya. Selain itu masyarakat di kalangan ibu rumah tangga juga sering menanam tanaman obat di pekarangan rumah. Namun, pemanfaatannya masih belum optimal karena kurangnya pengetahuan dalam mengolah potensi sumberdaya yang dimiliki. Salah satu tanaman yang belum dimanfaatkan secara optimal adalah pegagan yang banyak tumbuh di Desa Pagersari. Pegagan berkhasiat untuk meningkatkan imun, membersihkan darah, melancarkan peredaran darah, kecantikan, dan lain-lain. Pegagan ini dapat dijadikan masker yang dapat digunakan kapan saja sebagai penunjang kecantikan atau penunda penuaan dini. Masker pegagan bisa dikemas dalam bentuk menarik menjadi masker wajah. Selain itu teh pegagan ini terjamin proses pembuatanya karena melalui tahapan yang sudah sesuai dengan syarat P-IRT. Program pengabdian masyarakat (Pengembangan Masyarakat Desa Binaan) ini menginisiasi pembuatan masker pegagan yang ditanam sendiri serta siap digunakan kapan saja. Masyarakat Desa Pagersari akan dibina melalui penyuluhan dan praktik pembuatan masker  pegagan dari mulai pengolahan tanaman obat hingga berbentuk kemasan sehingga bisa dijadikan produk industri rumah tangga (P-IRT) sebagai bukti bahwa produk tersebut terjamin dan aman. Program ini dapat membantu pengembangan tanaman pegagan di Desa Pagersari yang dapat dijadikan sebagai produk kosmetik dan penunjang kecantikan untuk selanjutnya dapat dikemas dalam bentuk kemasan yang menarik dan dapat dijual sehingga meningkatkan perekonomian masyarakat. Kata kunci: Pegagan, Desa Pagersari, masker  ABSTRACT The use of plants as alternative medicine is found in many rural communities. One of them is Pagersari Village which is one of the villages in Pagerageung District, Tasikmalaya Regency. This village is located in the northern part of Tasikmalaya. Most of the livelihoods of the people there are farmers, so the environment is still relatively surrounded by rice fields, most of which are used for rice, secondary crops, vegetables and other crops. In addition, people among housewives also often plant medicinal plants in their yards. However, its utilization is still not optimal due to lack of knowledge in processing the potential of its resources. One of the plants that has not been used optimally is pegagan which grows a lot in Pagersari Village. Pegagan is efficacious for increasing immunity, cleansing the blood, improving blood circulation, beauty, and others. Pegagan can be used as a mask that can be used at any time to support beauty or delay premature aging. Pegagan masks can be packaged in an attractive form into a face mask. In addition, pegagan tea is guaranteed to be made because it goes through stages that are in accordance with the P-IRT requirements. This community service program (Development of Fostered Village Community) initiates the manufacture of pegagan masks that are self-grown and ready to be used at any time. The community of Pagersari Village will be fostered through counseling and the practice of making pegagan masks from processing medicinal plants to packaging so that they can be used as home industry products (P-IRT) as proof that the product is guaranteed and safe. This program can help the development of pegagan plants in Pagersari Village which can be used as cosmetic and beauty support products which can then be packaged in attractive packaging and can be sold so as to improve the community's economy. Keywords: pegagan, Pagersari village, mask
Uji Aktivitas Antidiare Ekstrak Etanol Daun Katuk (Breynia androgyna (L.)) pada Mencit Putih dengan Metode Transit Intestinal Nitya Nurul Fadilah; Gina Septiani Agustien; Lina Rahmawati Rizkuloh
Lumbung Farmasi: Jurnal Ilmu Kefarmasian Vol 3, No 2 (2022): Juli
Publisher : UNIVERSITAS MUHAMMADIYAH MATARAM

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31764/lf.v3i2.9791

Abstract

ABSTRAKDiare merupakan suatu masalah gangguan pada saluran pencernaan yang ditandai dengan pengeluaran feses cair berulang kali atau lebih dari 3 (tiga) kali sehari atau diare adalah frekuensi terjadinya defekasi lebih sering dari keadaan normal. Tanaman katuk mengandung senyawa-senyawa kimia meliputi flavonoid, saponin dan tanin. Tanin merupakan salah satu zat yang berkhasiat sebagai adstringensia sehingga diduga mampu memberikan efek antidiare.Tujuan penelitian ini adalah untuk melihat aktivitas antidiare dari tanaman katuk (Breynia androgyna).   Metode yang digunakan untuk menguji efek antidiare ekstrak etanol daun katuk yakni menggunakan metode transit intestinal. Dosis yang digunakan berturut-turut adalah (dosis I) 40 mg (dosis II) 80 mg dan (dosis III) 160 mg/20g BB. Berdasarkan hasil yang didapatkan pada uji aktivitas antidiare ekstrak etanol daun katuk dapat diketahui bahwa ekstrak daun katuk memiliki efek sebagai antidiare yang ditunjukkan dengan nilai rasio transit intestinal terbaik sebesar 0.39 pada dosis III sebesar 160mg/20gBB dan secara statistik siginifikan (p<0.05)   terhadap kontrol negatif. Kata kunci : Diare; Daun Katuk; Transit Intestinal; Tanin.ABSTRACTDiarrhea is a problem in the digestive tract, which is characterized by repeated discharge of liquid stools or more than 3 (three) times a day or diarrhea is the frequency of defecation more often than normal. Katuk plant contains chemical compounds including flavonoids, saponins and tannins. Tannins are one of the substances that are efficacious as an adstringensia so that they are thought to have an antidiarrheal effect. The purpose of this study was to see the antidiarrheal activity of the katuk (Breynia androgyna) plant. The method used to test the antidiarrheal effect of the ethanolic extract of katuk leaves is using the intestinal transit method. The doses used were (dose I) 40 mg (dose II) 80 mg and (dose III) 160 mg/20g BW. Based on the results obtained in the antidiarrheal activity test of the ethanol extract of katuk leaves, it can be seen that the katuk leaf extract has an antidiarrheal effect as indicated by the best intestinal transit ratio value of 0.39 at dose III of 160mg/20gBW and statistically significant (p<0.05) against the control negative. Keywords : Diarrhea; Katuk Leaves; Intestinal Transit; Tannins
UJI STABILITAS FISIK SEDIAAN MASKER GEL PEEL-OFF EKSTRAK ETANOL DAUN KENITU (Chrysophyllum cainito L.) Gina Septiani Agustien; Nitya Nurul Fadilah; Dina Fitri Nusyifa
Jurnal Insan Farmasi Indonesia Vol 5 No 2 (2022): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v5i2.1064

Abstract

Kenitu leaves contain flavonoids which function as antioxidants that can counteract the bad effects of free radicals, the antioxidant effect will be better if formulated in topical dosage forms. One of the topical dosage forms for use on the face is a peel-off gel mask, its use is easy to remove like an elastic membrane. This study aims to determine the physical stability of the peel-off gel mask preparation of kenitu leaves ethanol extract. The research method was experimental by making three peel-off gel mask formulations based on variations in extract concentration, namely F1 (2%), F2 (4%) and F3 (8%). Evaluations were carried out on the physical stability of the preparation, including organoleptic observations, homogeneity, pH, adhesion, dispersibility, drying time of the preparation, and viscosity. The results showed that the physical stability test of the peel-off gel mask preparation of kenitu leaves ethanol extract could be formulated in the form of a peel-off gel mask preparation, and the best mask formula was F1 with an extract concentration of 2%.
UJI AKTIVITAS ANTIDIARE TABLET EKSTRAK ETANOL DAUN KATUK (Sauropus androgynus L.) Merr. PADA MENCIT PUTIH (Mus musculus) Nurul Fadilah, Nitya; Melinia, Meena; Septiani Agustien, Gina
Jurnal Insan Farmasi Indonesia Vol 6 No 2 (2023): Jurnal Insan Farmasi Indonesia
Publisher : Sekolah Tinggi Ilmu Kesehatan ISFI Banjarmasin

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36387/jifi.v6i2.1563

Abstract

Diarrhea is a condition in which a person experiences excretion of feces more than 3 times a day accompanied by an increase in volume and dilu­­tion which results in dehydration and even causes death. The aim this study was to determine the antidiarrheal activity of ethanol extract tablets of katuk leaves (Sauropus androgynus L.) Merr. which contains tannins, flavonoids and alkaloids as anti-diarrheal compounds because they can inhibit intestinal motility. This test uses the intestinal transit method which measures the length of the intestine through which the marker passes. The number of mice used was 25 which were divided into 5 groups. The positive control group 1 used loperamide HCl at a dose of 4 mg/kgBW. Group 2 was negative control with tablets without extract, Group 3 with tablet extract 80 mg/kgBW, group 4 tablets with extract dose 160 mg/kgBW and group 4 with tablet extract 320 mg/kgBW. The results of this test show that in formulation 1 it has an activity value of 40.32%, in formulation 2 it is 43.21% and in formulation 3 it is 45.2%. Tablet preparations with the best results were in formulation 3 with an extract dose of 320 mg/kgBW which showed the best results
Co-Authors Aas Nuraisah Adila Awaludin AHMAD FAHRIZAL Ali Nofriyaldi Alin Marlina Annisa Annisa AYU RAHMAWATI Dila Yanti Dina Anastasya Dina Fitri Nusyifa Fitri, Hilda Farhatul Ihsanul Khindiq Iqbal Abdul Raup Juniati, Nia Lina Rahmawati Rizkuloh Melinia, Meena Nitya Nurul Fadilah Richa Mardianingrum Rosalina L.S, Fazrisa Ruswanto, Ruswanto Suhardiana, Eddy Susanti Susanti Susanti Susanti WAHYU FIRMANSYAH