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All Journal Indonesian Journal of Cancer Chemoprevention Indonesian Journal of Biotechnology Jurnal Kefarmasian Indonesia Indonesian Journal of Pharmacology and Therapy
Ikawati, Muthi'
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Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Materials Science & Nanotechnology Medicine & Pharmacology

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Penggunaan Metode Hybrid e-Learning untuk Praktikum Imunologi Farmasi di Fakultas Farmasi Universitas Gadjah Mada Ikawati, Muthi'; Hermawan, Adam; Sahid, Muhammad Novrizal Abdi; Kristina, Susi Ari; Sasmito, Ediati
Jurnal Kefarmasian Indonesia VOLUME 11, NOMOR 1, FEBRUARI 2021
Publisher : Pusat Penelitian dan Pengembangan Biomedis dan Teknologi Dasar Kesehatan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22435/jki.v11i1.3332

Abstract

Laboratory work of Pharmaceutical Immunology, Faculty of Pharmacy UGM aims to provide skills of applying antigens, antibodies, and immunological techniques in pharmaceutical; and ideally each student should be able to perform it completely. However, the limitation of time and facilities making the learning process ineffective. An innovative learning method such as hybrid e-learning is expected to increase the learning effectiveness. Learning materials and online quizzes/discussions were uploaded and carried out using elisa.ugm.ac.id (eLisa), respectively, combined with on-site works in the laboratory. The method was evaluated by examination scores and final grades. Student participations in online quizzes increased from first to fourth quiz (average participation rate 98.86±0.87%). Compared to the conventional method applied in 2016 (n=207), the examination average score did not increase; however, the percentage of students whose score is 90-100 were higher in the hybrid e-learning. The average final grade of the hybrid e-learning was 81.43±0.70; whereas the conventional method of 2016 was 80.22±5.22. More than 80% students (n=48) expressed easiness in following courses and were satisfied with the online learning materials’ quality. Hence, the hybrid e-learning results positive effects in increasing the effectiveness of the learning process. Development of more interactive online platforms is needed to optimize the learning process.
The Chemopreventive Potential of Diosmin and Hesperidin for COVID-19 and Its Comorbid Diseases Utomo, Rohmad Yudi; Ikawati, Muthi'; Putri, Dyaningtyas Dewi Pamungkas; Salsabila, Irfani Aura; Meiyanto, Edy
Indonesian Journal of Cancer Chemoprevention Vol 11, No 3 (2020)
Publisher : Indonesian Society for Cancer Chemoprevention

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14499/indonesianjcanchemoprev11iss3pp154-167

Abstract

The COVID-19 becomes worse with the existence of comorbid diseases such as cardiovascular diseases, metabolic syndromes, inflammation, degenerative diseases, as well as cancer. Therefore, a comprehension approach is needed to combat such comorbid conditions, not only focusing on the virus infection and replication but also directed to prevent the raising comorbid symptoms. This study analyzed the potential natural compounds, especially diosmin and hesperidin, as an anti-SARS-CoV-2 and chemopreventive agent against several COVID-19 comorbid diseases by using an in-silico method. Diosmin and hesperidin together with other natural compounds and existing viral drugs (lopinavir, nafamostat, and comastat) were docked into several proteins involved in SARS-CoV-2 infection and replication namely SARS-CoV-2 protease (PDB:6LU7), spike glycoprotein-RBD (PDB:6LXT), TMPRSS2, and PD-ACE2 (PDB:6VW1) using MOE software. The interaction properties were determined under docking score values. The result exhibited that diosmin and hesperidin performed superior interaction with all the four proteins compared to the other compounds, including the existing drugs. Moreover, under literature study, diosmin and hesperidin also elicit good chemopreventive properties against cardiovascular disorder, lung and kidney degeneration, as well as cancer development. In conclusion, diosmin and hesperidin possess high opportunity to be used for the COVID-19 and its the comorbid diseases as chemopreventive agents.Keywords: chemoprevention, COVID-19, diosmin, hesperidin, SARS-CoV-2 infection
Single nucleotide polymorphism of AGT rs699 in the pathogenesis of hypertension and ACE inhibitors response: a narrative review Hartienah, Septiayu Dwi; Ikawati, Muthi'; Zullies Ikawati
Indonesian Journal of Pharmacology and Therapy Vol 5 No 2 (2024)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.9395

Abstract

Hypertension is a chronic cardiovascular disease that affects more than one billion people in the world. Angiotensinogen in the renin-angiotensin-aldosterone system (RAAS) is the main precursor encoded by angiotensinogen (AGT) gene and plays an important role in the development of hypertension. Single nucleotide polymorphism (SNP) of AGT gene is thought related to the pathogenesis of hypertension and angiotensinogen levels in plasma that may affect response to ACE inhibitors. This article reviewed the association of SNP AGT rs699 with the pathogenesis of hypertension and ACE inhibitors response. A total of 14 articles published from 1995 to 2023 were collected from databases including NCBI, Google Scholar, PubMed and Science Direct. Several studies in different populations have been conducted and showed various results. The T allele or TT genotype of AGT rs699 was associated in the pathogenesis of hypertension. However, the association between AGT rs699 and ACE inhibitor response shows inconsistent results, thus further research is needed.
Pentagamavunone-1 and its derivative, Chemoprevention Curcumin Analog-1.1, modulate PD-L1 and CD80 expression in breast cancer stem cells Alif, Iffan; Putra, Agung; Jenie, Riris Istighfari; Ikawati, Muthi'
Indonesian Journal of Biotechnology Vol 31, No 2 (2026)
Publisher : Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijbiotech.114332

Abstract

Breast cancer stem cells (bCSCs) exhibit high plasticity, therapeutic resistance and immune evasion, making them critical targets for effective cancer immunotherapy. Pentagamavunone-1 (PGV-1), a curcumin analog, and its derivative, Chemoprevention Curcumin Analog-1.1 (CCA-1.1), possess cytotoxic and reactive oxygen species (ROS)-modulating properties. However, their potential role in modulating immune-related phenotypes in bCSCs remains unclear. In the study, bCSCs derived from the MDA-MB-231 cell line were treated with PGV-1 or CCA-1.1 to evaluate cytotoxicity, apoptosis, cell cycle distribution, stemness-associated markers and immune checkpoint expression. Cell viability was assessed using the CCK-8 assay. Apoptotic, stemness and immune-checkpoint profiles were analyzed using flow cytometry. PGV-1 exhibited stronger cytotoxicity against bCSCs than CCA-1.1, characterized by lower IC50 values (10.70 and 28.78 µM for PGV-1 and CCA-1.1 respectively at 24 h) and greater induction of apoptosis in a dose-dependent manner. Both compounds at concentrations of 2.67 and 7.19 µM significantly (p < 0.001) induced G2/M cell cycle arrest and reduced the CD44+CD24– stem-like population, indicating loss of stemness and enhanced differentiation. Importantly, PGV-1 significantly downregulated PD-L1 while upregulating CD80, suggesting a shift toward immunophenotypic alterations associated with a potentially more immunogenic profile. These dual effects of cytotoxic and preliminary immunophenotypic modulation highlight the ability of PGV-1 to overcome immune resistance in bCSCs. Further investigation using immune cell–based functional assays or in vivo models is required to validate whether the observed immunophenotypic modulation translates into functional immune activation and to assess the potential of PGV-1 in a co-immunotherapy setting.
Co-Authors Adam Hermawan Agung Putra Alif, Iffan Dyaningtyas Dewi Putri Pamungkas Ediati Sasmito Edy Meiyanto Riris Istighfari Jenie Rohmad Yudi Utomo Sahid, Muhammad Novrizal Abdi Salsabila, Irfani Aura Septiayu Dwi Hartienah Susi Ari Kristina