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All Journal Jurnal Penelitian Farmasi dan Herbal Jurnal Kedokteran Hewan
Meliala, Linta
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Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Veterinary

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linta meliala,roito yuliana UJI EFEKTIVITAS ANTIDIARE EKSTRAK ETANOL DAUN GAGATAN HARIMAU (Vitisgracilis BL) PADA TIKUS JANTAN PUTIH Meliala, Linta
Jurnal Penelitian Farmasi & Herbal Vol 6 No 1 (2023): JURNAL PENELITIAN FARMASI & HERBAL
Publisher : Fakultas Farmasi Institut Kesehatan DELI HUSADA Deli Tua

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36656/jpfh.v6i1.1555

Abstract

Abstract Diarrhea is the abnormal passage of loose or watery stools, with a frequency of more than three times a day. Diarrhea can be caused by bacteria. Gagatan Harimau leaves are known to have antibacterial properties. This research was conducted using an experimental method in the field of pharmacology at the Pharmacology Laboratory, Faculty of Pharmacy, Deli Husada Health Institute Delitua, using 25 rats induced with castor oil and divided into 5 treatment groups: negative control (1% CMC Na), positive control (Loperamide HCl), and treatment groups with ethanol extract of Gagatan Harimau leaves at doses of 50 mg/kg body weight (BW), 100 mg/kg BW, and 200 mg/kg BW. The sample used was Gagatan Harimau leaves (Vitis graillis BL), which were extracted by maceration using 96% ethanol as the solvent and concentrated using a rotary evaporator. The phytochemical screening results of Gagatan Harimau leaves showed the presence of flavonoids, saponins, alkaloids, and tannins. The results of the antidiarrheal effect test showed that the ethanol extract of Gagatan Harimau leaves at doses of 50, 100, and 200 mg/kg BW had antidiarrheal effects on male rats. The 200 mg/kg BW dose of ethanol extract showed the most effective antidiarrheal effect compared to the 50 and 100 mg/kg BW doses. The extract from Gagatan Harimau leaves (Vitis gracillis BL) exhibited antidiarrheal effects on male white rats induced with castor oil.
EFFECT OF HESPERETIN TREATMENT ON BLOOD GLUCOSE LEVEL, SPERMATOZOA QUALITY, AND SPERMATOZOA QUANTITY IN ALLOXAN-INDUCED DIABETIC MICE Nerdy, Nerdy; Meliala, Linta; Barus, Bunga Rimta; Lestari, Puji; Ginting, Selamat; Ariani, Peny; Mierza, Vriezka; Bakri, Tedy Kurniawan
Jurnal Kedokteran Hewan Vol 15, No 1 (2021): March
Publisher : Universitas Syiah Kuala

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21157/j.ked.hewan.v15i1.18406

Abstract

Male infertility has occurred rapidly in the last few decades, primarily in developing countries. An antioxidant, hesperetin is a flavonoid that is found in abundance in orange peels. The aims of this research were to determine the effect of hesperetin on blood sugar levels, spermatozoaquality, and spermatozoa quantity. The research structure included induction of diabetes mellitus and treatment for 8 weeks, followed bydetermination of blood sugar levels, spermatozoa quality, and spermatozoa quantity. Hesperetin has the ability to restore blood sugar levels, spermatozoa quantity, seminiferous tubules diameter, and testicular weight, volume, and germinal epithelial layer thickness with significant difference from the normal control group. Hesperetin did not fully restore spermatozoa motility, viability, and morphology with significant difference from the normal control group, nor from the positive control group. However, overall, hesperetin decreased blood glucose levels, increased spermatozoa quantity, and improved the spermatozoa quality in alloxan-induced diabetes mellitus mice. Dose-dependent activity was observed with the optimum dose at 200 mg/kg body weight.
Co-Authors Ariani, Peny BAKRI, TEDY KURNIAWAN Barus, Bunga Rimta GINTING, SELAMAT Mierza, Vriezka Nerdy, Nerdy PUJI LESTARI