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All Journal Journal Of Widya Medika Junior Jurnal Filsafat Indonesia CRJIM (Clinical and Research Journal in Internal Medicine) Geosfera: Jurnal Penelitian Geografi Jurnal Indonesia : Manajemen Informatika dan Komunikasi
Merici, Angela
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Computer Science & IT Earth & Planetary Sciences Education Environmental Science Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Library & Information Science Medicine & Pharmacology Nursing Public Health Social Sciences Other

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The Effect of Artesunate and Brotowali (Tinospora Crispa) Combination on Histopathological, and Expression of Nuclear Factor Kappa B (NF-kβ) in Renal Tubules of Mice Infected With Plasmodium Berghei Merici, Angela; Fitri, Loeki Enggar; Budiarti, Niniek
Clinical and Research Journal in Internal Medicine Vol 1, No 1 (2020): New: The First Volume of Clinical and Research Journal in Internal Medicine
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.crjim.2020.001.01.5

Abstract

Brotowali (BR) extract (Tinospora crispa) can be used as an antimalarial. Aim: to determine the effect of BR extract in histopathological and expression of NFκB in mice tubules infected by Plasmodium berghei treated by artesunate (AR). Method: we used 42 C57BL / 6J strain mice as experimental animals, which were randomly divided into 7 groups : negative control (NC), positive control (PC), treatment group consist of AR 32 mg/kb (group 1); BR 70 mg/kg (group 2), combination of AR+BR 50 mg/kg (group 3), AR+BR 60 mg/kg (group 4), and AR+BR 70 mg/kg (group 5).  Histological examination (hematoxylin-eosin (HE) staining) and expression of NFKB (immunohistochemical staining) in the kidneys were performed on 7th and 14th. Result: compared to PC group, BR with doses of 70 mg until 14th day, improved the degree of tubular necrosis, interstitial fibrosis, tubular degeneration, and inflammatory cell infiltration (p <0.001) but did not reach NC group (p <0.05). The combination of AR+BR until the 14th  day with dose of 50, 60, 70 mg all of dose improves significantly in-term of degree of tubular cell necrosis and inflammatory cell infiltration. The degree of interstitial fibrosis on 14th day only improved in group 4 and 5 (p<0.001 and p=0.003). The level of NF-kB expression on day 7 and day 14 was reduced in group 2, group 4, and group 5 compared to PC group. There was positive correlation on 7th and 14th between NF-kβ expression and tubular degeneration, tubular cell necrosis, inflammatory cell infiltration, and interstitial fibrosis. Conclusion: the combination of AR+BR extract can improve histopathological features and reduce NF-kβ expression in mice tubules infected by Plasmodium berghei with an optimal dose was 60 mg/day for 7-14 days or 70 mg for 7 days.
THE CORELATION OF THE QUALITY OF ANTENATAL CARE VISITS WITH THE INCIDENT OF ASPHYXIA NEONATORUM AT PHC HOSPITAL SURABAYA Noorlaksmiatmo, Harno Prihadi; Budipramana, Edwin; Tahalele, Paul L; Merici, Angela
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 6, No 3 (2024): July
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v6i3.5762

Abstract

Background: Birth asphyxia is the one of the very common problem in neonatal health care. Its incidence is very high in the developing country where health facilities are restricted to urban area, and these factors can be prevented through standard Antenatal Care (ANC) visits. ANC is medical care provided by healthcare professionals to mothers during pregnancy, administered by medical personnel and conducted according to established standards. This ANC monitors the health and development of both the mother and the fetus for early detection of risks and health issues during pregnancy.Objective: To determine the relationship between the quality of ANC visits and the occurrence of Asphyxia Neonatorum at PHC Hospital Surabaya.Method: This research is an observational analytic study with a case-control study design, employing a retrospective approach. The sampling in the study utilized probability sampling, specifically employing the simple random sampling technique. The statistical method used to examine the relationship between the quality of ANC visits and Asphyxia (APGAR Score ≤3-6) through the analysis of odds ratio comparison using the Chi-square statistical test.Result: The statistical analysis of the relationship between the quality of ANC visits and the occurrence of Asphyxia shows significant results with a p-value of 0.001 (p < 0.05).Conclusion: The compliance of pregnant women in adhering to standard ANC visits ensures the health of both the mother and the baby during pregnancy.
Efektivitas Model Pembelajaran Exo-Olo Task Terhadap Critical Thinking Sebagai Implementasi Kurikulum Merdeka Merici, Angela; Widiyanto, Gabriel Pradipta Tyas
Geosfera: Jurnal Penelitian Geografi Vol 3, No 1 (2024): Geosfera: Jurnal Penelitian Geografi
Publisher : Universitas Negeri Gorontalo

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37905/geojpg.v3i1.21016

Abstract

Efektivitas Model Pembelajaran EXO-OLO Task Terhadap Critical Thinking Sebagai Implementasi Kurikulum Merdeka. Hasil penelitian diperkuat oleh teori dan temuan penelitian sebelumnya yang menyebutkan bahwa model pembelajarn EXO-OLO Task dapat mencitakan aktivitas belajar yang dapat mencapai proses belajar secara bertahap sehingga dapat mencapai pemikiran kritis akan konsep sesuai dengan kajian fakta yang logis. Pentingnya penelitian ini dilakukan adalah sebagai evaluasi terhadap perubahan tindakan yang akan diberikan dalam implementasi kurikulum Merdeka yang menuntut penilaian yang holistic dengan karakter peserta didik yang berbeda. Tujuan penulisan ini adalah untuk efektifitas model pembelajaran EXO-OLO Task terhadap berpikir kritis sebagai implementasi kurikulum merdeka. Metode yang dilakukan dalam penelitian ini adalah metode kualitatif deskriptif dengan pendekatan studi kasus menggunakan instrumen indikator hasil proses belajar dan observasi aktivitas belajar dengan menggunakan angket dan teknik wawancara sebagai bentuk validasi kebenaran data dan hasil penelitian ini sangat relevan dengan kurikulum merdeka. Hasil penelitian diperkuat oleh teori dan temuan penelitian sebelumnya yang menyebutkan bahwa model pembelajarn EXO-OLO Task dapat mencitakan aktivitas belajar yang dapat mencapai proses belajar secara bertahap sehingga dapat mencapai pemikiran kritis akan konsep sesuai dengan kajian fakta yang logis dengan kategori sangat tinggi.
Peramalan Persediaan Barang Menggunakan Metode Weighted Moving Average di CV. Multipaper Stationery Merici, Angela; Saprudin, Usep
Jurnal Indonesia : Manajemen Informatika dan Komunikasi Vol. 5 No. 2 (2024): Mei
Publisher : Lembaga Penelitian dan Pengabdian Kepada Masyarakat (LPPM) STMIK Indonesia Banda Aceh

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.35870/jimik.v5i2.742

Abstract

This research aims to implement the Weighted Moving Average method for forecasting inventory and getting prediction results on CV. Multipaper Stationery with the smallest possible error rate. In this method, researchers collect data from processes in the field to obtain the data needed in this research. The data taken is sales data for 2022-2023. Data analysis uses the Weighted Moving Average method. The results of the research show that from the six items used as research samples, the Weighted Moving Average value for the next 1 year is obtained, namely Sidu notebook 38 is 106764 pack, Sidu notebook 58 is 83877 pack, Techno Standard Pen is 40190 dozen, HVS Sinar Dunia A4 is 74589 rim, world rays F4 is 64137 rim and for Faber Castle pencil it is 40152 dozen.
Kritik Levinas terhadap Kebijakan Luar Negeri Realisme : Konsep Etika dan Tanggung Jawab terhadap “Liyan”: Levinas's Critique of Realist Foreign Policy: The Concept of Ethics and Responsibility to the “Liyan” Merici, Angela
Jurnal Filsafat Indonesia Vol. 8 No. 2 (2025)
Publisher : Undiksha

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/jfi.v8i2.87312

Abstract

This article aims to analyze the realist foreign policy in the international relation field from the perspective of ethics of the responsibility for “the Others” by Emmanuel Levinas. The methodology used is the qualitative method with the literature studies by collecting and analyzing the cases from the journal and media reports. The findings in this analysis is that realist foreign policy is in really opposite way to the concept of responsibility towards the "Other," where basic human rights are neglected and the domination of power by taking the benefits from the weak society either from the aspect of power, capability or even military from the example of anti-migrant policy by Hungary and Invasion of Irak by the United States in 2003. By the critique from Levinas, the state actors as the foreign policy makers in the states could put the impact of the policy for “the Others” in their consideration. This perspective of Levinas could also contribute to the alternative and reminder for the chosen foreign policy which should be more humane by respecting human dignity, which must be upheld and cannot be disregarded.
Co-Authors Budipramana, Edwin Loeki Enggar Fitri Niniek Budiarti B Noorlaksmiatmo, Harno Prihadi Paul L Tahalele Saprudin, Usep Widiyanto, Gabriel Pradipta Tyas