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All Journal JBIO: jurnal biosains (the journal of biosciences) Best Journal (Biology Education, Sains and Technology)
Nasution, Muhammad Yusuf
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Education Immunology & microbiology Medicine & Pharmacology Public Health

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Uji Aktivitas Antibakteri Ekstrak Etanol Daun Sirih Hijau (Piper betle L.) Terhadap Bakteri Escherichia coli dan Stapyhlococcus aureus Hasibuan, Atika Aulya; Nasution, Muhammad Yusuf
BEST Journal (Biology Education, Sains and Technology) Vol 8, No 2 (2025): September 2025
Publisher : Program Studi Pendidikan Biologi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/best.v8i2.12043

Abstract

Penelitian ini bertujuan untuk mengetahui aktivitas antibakteri ekstrak etanol daun sirih hijau (Piper betle L.) terhadap Escherichia coli dan Staphylococcus aureus serta menentukan konsentrasi yang paling efektif dalam menghambat pertumbuhannya. Metode penelitian menggunakan difusi cakram dengan variasi konsentrasi ekstrak 40%, 60%, 80%, dan 100%, serta kontrol positif dan negatif. Hasil uji menunjukkan bahwa ekstrak etanol daun sirih hijau memiliki aktivitas antibakteri terhadap kedua bakteri uji. Konsentrasi 60% paling efektif menghambat pertumbuhan E. coli dengan kategori kuat, sedangkan konsentrasi 100% paling efektif menghambat pertumbuhan S. aureus dengan kategori sedang. Uji statistik ANOVA menunjukkan adanya perbedaan signifikan antar perlakuan (p = 0,000). Analisis GC-MS juga mengidentifikasi senyawa aktif seperti hydroxychavicol, palmitic acid, dan phytol yang berperan dalam aktivitas antibakteri. Dengan demikian, ekstrak etanol daun sirih hijau berpotensi sebagai sumber antibakteri alami yang efektif dalam menghambat pertumbuhan bakteri patogen
GC-MS ANALYSIS OF SECONDARY METABOLITES OF SENGGANI LEAVES (Melastoma malabatrichum L.) Nasution, Muhammad Yusuf; Rangkuti, Marlinda Nilan Sari; Situmorang, Nurbaity
JBIO: jurnal biosains (the journal of biosciences) Vol. 10 No. 3 (2024): JBIO : JURNAL BIOSAINS (THE JOURNAL OF BIOSCIENCES)
Publisher : Universitas Negeri Medan

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24114/jbio.v10i3.62912

Abstract

Traditional medicinal plants have long been used and trusted by the community to treat various diseases. The senggani plant is useful for reducing fever (antispiretic), pain reliever (analgesic), urine laxative (diuretic), treating vaginal discharge (leukorrhea), and as a medicine for various types of wounds. This research was conducted using extracts of Melastoma malabatricum (L.) leaves extracted using methanol as a solvent. GC-MS analysis of secondary metabolites of senggani leaves (Melastoma malabatrichum L.) was carried out as a first step to determine the content of active secondary metabolite compounds contained in senggani leaves.The results of this study show that 8 peaks were observed during maximum run time of 40 min. The results revealed that, compounds such as 3-Hexadecyloxycarbonyl-5-(2-hydroxyethyl)-4-methylimidazolium, Melezitose, Thiosulfuric acid, Neophytadiene, 9-Icosyne, Phytol, Hexadecanoic acid dan 9-Octadecenoic acid (Z) were present in the methanolic extract of Melastoma malabatrichum (L.) which can mostly contribute to several therapeutic activities such as antimicrobial.
Co-Authors Hasibuan, Atika Aulya Rangkuti, Marlinda Nilan Sari Situmorang, Nurbaity