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All Journal Althea Medical Journal Journal of the Indonesian Medical Association : Majalah Kedokteran Indonesia Journal Orthopaedi and Traumatology Surabaya (JOINTS) International Islamic Medical Journal
Al Hajiri, Aufar Zimamuz Zaman
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Religion Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Medicine & Pharmacology Public Health

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A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativa for Osteoarthritis Al Hajiri, Aufar Zimamuz Zaman; Abdillah, Diaz Syafrie; Zulfikar, Mohammad Qoimam Bilqisthi
Jurnal Medis Islam Internasional Vol 1 No 2 (2020): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i2.1622

Abstract

Osteoarthritis (OA) is the most common type of arthritis (inflammation of the joints). OA can affect all cartilage throughout the body, including the spine, but mainly attacks the legs from the pelvis, especially the knee to the ankle which affects about 10% of men and 18% of women over 60 years old. Pharmacotherapy, surgery, and complementary therapy are the currently managements of OA. Nigella sativa (NS) is one of the herbal plants which is part of the prophet's medicines in the Islamic world which still used. Thymoquinone (TQ) is one of NS compound, has an anti-inflammatory effect by inhibit the formation of eicosanoids in leukocytes and lipid peroxidation, or inhibit the expression of PF NF-κB subunits and p50 subunits with TNF-a promoters, and reduce levels of C-reactive protein (CRP). TQ also has a chondroprotective effects mechanism by decreases prostaglandin E2 (PGE) mediated by IL-1β and inhibits MMP synthesis in chondrocytes. Through its anti-inflammatory and chondroprotective effect, NS is a potential therapeutic agent which beneficial use for OA management without toxicological effects when given.
The Role of Religion and Spirituality in Managing Residual Schizophrenia: Article Review Al Hajiri, Aufar Zimamuz Zaman; AS, Nur Azizah; Algristian, Hafid
Jurnal Medis Islam Internasional Vol 3 No 1 (2021): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v3i1.2493

Abstract

Background: Residual Schizophrenia is a chronic condition of schizophrenia characterized by a history of leastwise one psychotic episode with more prominent negative symptoms. Schizophrenic patients who have persistent psychotic symptoms and patients with residual schizophrenia should receive adequate pharmacotherapy, and may consider additional cognitive therapy, as it has been shown to help reduce relapse rates, reduce psychotic symptoms, and improve or stabilize the patient's mental state. Objective: To determine the role of religion and spirituality in the management of patients with residual schizophrenia.Methods: The design of this research is a literature review or library review, which is a systematic, direct, and reproducible research method by identifying, evaluating, and synthesizing published research.Result: Patients with a higher level of religion or spirituality or their strong personal belief system are more likely to use positive appraisal to deal with their illness or problem which includes giving positive meaning to the situation and being optimistic. Conclusion: The presence of religion and spirituality help the coping mechanisms of residual Schizophrenia patients which also improves patient management, accelerate the healing process, and increases QOL of patients. Keywords: Spirituality, Religion, Residual Schizophrenia.
Alcoholic Cardiomyopathy: A Literature Review Zurohidah, Aina; Al Hajiri, Aufar Zimamuz Zaman; Silaban, Rusdiana; Putri, Mutiara Aswar Eka; Mafruroh, Ilfia Hajar; Syarifah, Mustika Chasanatusy
Jurnal Medis Islam Internasional Vol 3 No 2 (2022): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v3i2.3526

Abstract

Background: Cardiomyopathy is a heart muscle disorder so which the heart cannot contract optimally. Alcoholic cardiomyopathy is a type of cardiomyopathy that dilates due to long-term alcohol consumption. The prevalence of alcoholic cardiomyopathy is higher in men than women. The age group with the most alcoholic cardiomyopathy was 45 to 74 year. Death from alcoholic cardiomyopathy had an autopsy result marked muscle dilatation. A toxicological examination can show the level of alcohol consumed. The cause of death in alcoholic cardiomyopathy is muscle dilatation due to chronic ethanol abuse. Islam expressly forbids something that makes losing mind, like alcohol. Alcohol has many disadvantages for the consumer in the form of loss of mind and turning away from Allah. Objective: This report aims to learn more about the definition, pathophysiology, clinical manifestation, and treatment of Alcoholic Cardiomyopathy. Also, Knowing and explaining Alcoholic Cardiomyopathy in terms of death and Islamic views. Methods: The design of this research is a literature review or library review, which is a systematic, direct, and reproducible research method by identifying, evaluating, and synthesizing published research.  Result: Alcoholic cardiomyopathy is a clinical diagnosis made in a patient with a set of findings that include a history of excessive alcohol consumption, possible physical signs of alcohol abuse (e.g., parotid disease, telangiectasia or spider angiomata, altered mental status, cirrhosis), heart failure, and other evidence consistent with dilated cardiomyopathy. People who frequently consume alcohol can cause nutritional disorders, especially vitamin B1 deficiency can cause cardiomyopathy. Alcohol will also cause abnormalities in the structure and function of mitochondria in heart cells. These abnormalities include enlarged mitochondrial structure, decreased metabolism, lack of several enzymes decreased ion transport, increased calcium flow, glycogen accumulation, and decreased ATP production. Conclusion: Cardiomyopathy is a heart muscle function disorder characterized by the loss of the ability of the heart muscle to pump blood so that the blood supply is not optimal and results in death. The most common cause is chronic alcohol consumption, which causes dilatation of the heart muscle. At the same time, alcohol is an ingredient that is forbidden to be consumed by Muslims because of its more significant impact.
Short-term evaluation of hypertonic dextrose prolotherapy intra-articular injection on femoral cartilage thickness among Knee Osteoarthritis Patients with Obesity Pane, Rita Vivera; Aisyah; Handayani; Al Hajiri, Aufar Zimamuz Zaman
Jurnal Medis Islam Internasional Vol 6 No 2 (2024): December
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v6i2.6279

Abstract

Introduction: The impact of obesity greatly influences morbidity rates and leads to increase the risk of knee osteoarthritis (KOA). Objective: This study aimed to evaluate the short-term effect of intra-articular injection of hypertonic dextrose prolotherapy (HDP) on femoral cartilage (FC) thickness among KOA with obese patients. Methods: This is a quasi-experimental clinical trial study. KOA patients with obesity registered from May to August 2023 in the Department of Physical Medicine and Rehabilitation (PM&R) RSUD Haji Provinsi Jawa Timur, Surabaya, Indonesia. The intervention group received an HDP injection, while the control group received a normal saline (NS) injection. The FC thickness was scanned with musculoskeletal ultrasound (US) before the intervention, 2 weeks, and 6 weeks after intervention. Mean difference within-group and intra-group was analyzed statistically with a significant value of P < 0.05. Results: 38 participants who were diagnosed with KOA and obesity were involved in this study. The FC thickness before intervention in the NS group at the LC, IC, and MC sites was 1.47 ± 0.45 1.23 ± 0.47 1.33 ± 0.49 mm, respectively, while in the HDP group it was 1.57 ± 0.70 1.38 ± 0.65 1.33 ± 0.61 mm. Within-group analysis of each group from pre-intervention until 6 weeks using repeated measurement ANOVA showed significant values in the HDP group at all sites, including LC, IC, and MC, with each value P < 0.05. Conclusions: The short-term effect of HDP injection is beneficial in increasing FC thickness in KOA with obese patients.
Hypertonic Dextrose Prolotherapy Injection Improves Clinical Outcomes in Shoulder Impingement Syndrome with Diabetes Mellitus: A Quasi-Experimental Study Pane, Rita Vivera; Al Hajiri, Aufar Zimamuz Zaman
(JOINTS) Journal Orthopaedi and Traumatology Surabaya Vol. 14 No. 2 (2025): October 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/joints.v14i2.2025.99-104

Abstract

Background: Shoulder impingement syndrome (SIS) is the most common cause of shoulder pain. Current conservative management approaches often require years for patients to achieve pain relief. This study aimed to identify the effects of hypertonic dextrose prolotherapy (HDP) injections on pain levels and shoulder functionality in SIS patients with diabetes mellitus. Methods: A quasi-experimental study was conducted recruiting SIS patients at Hajj Regional Hospital, Surabaya, Indonesia, from January 2022 to December 2023. The study group was divided into two: the HDP group, which received a 5 mL injection of HDP at a concentration of 20%, and the control group, which received pharmacotherapy and regular rehabilitation therapy. While the control group received regular pharmacotherapy and rehabilitation therapy only. The study outcomes assessed were the Numeric Rating Scale (NRS) and shoulder Active Range of Motion (AROM). The evaluation was conducted three times: before the intervention, immediately after the intervention, and two weeks after the intervention. Results: A total of 20 study participants were divided into two groups: 10 in the HDP group and 10 in the control group. Inter- and intragroup analyses showed significant differences in NRS mean values between the HDP and control groups (p < 0.05). Similarly, AROM analysis showed significant differences in mean values between the HDP and control groups, both inter- and intra-group (p < 0.05). Conclusions: HDP injection reduces pain intensity and improves shoulder AROM within two weeks after injection.
Perbandingan Program Rehabilitasi Reguler dengan Penambahan Terapi Membaca Al-Qur’an Terhadap Kebugaran Kardiorespirasi Penyintas Covid-19 Pane, Rita Vivera; Donastin, Adyan; Al Hajiri, Aufar Zimamuz Zaman
Majalah Kedokteran Indonesia Vol 72 No 5 (2022): Journal of The Indonesian Medical Association - Majalah Kedokteran Indonesia, Vo
Publisher : PENGURUS BESAR IKATAN DOKTER INDONESIA (PB IDI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.47830/jinma-vol.72.5-2022-812

Abstract

Introduction: Rehabilitation program has been proven to be able to restore the cardiorespiratory function of Covid-19 survivors. Reciting Holy Qur’an are associated with a more relaxed and lowered heart rate of the reciter. The present study aims to compare the regular rehabilitation program with addition of Reciting Holy Qur’an on cardiorespiratory fitness among moslem Covid-19 survivors. Method: This quantitative experimental study involved 18 moslem patients who were assigned into two groups. Eight patients in the interventional group received additional Qur’an recitation every day at least 20 pages, divided into several sessions according to the participants’ ability and opportunity. Meanwhile, ten patients in the control group received regular rehabilitation programs with mild to moderate intensity. The cardiorespiratory fitness level was evaluated by a count test (CT), incentive spirometry test (IST), and a 6-minute walk test (6MWT). The measurement was performed three times: before intervention, the first week, and the second week after treatment. Result: The participants were eight males and ten females with an age average of 51.9 ± 9.5 years. Both groups showed significant differences before and after treatment in the first and second week in terms of CT, IST, and 6MWT (p less than 0.05). There was a significant difference between the two groups in the first week in the IST result (p less than 0.05), no significant difference in the second week was noticed. Conclusion: The Covid-19 survivors receiving additional Holy Qur’an recitation exhibit faster cardiorespiratory fitness improvement than the control group.
Clinical Outcomes of Hypertonic Dextrose Prolotherapy Injection in Obese Patients with Knee Osteoarthritis: A Quasi-Experimental Study Pane, Rita Vivera; Al Hajiri, Aufar Zimamuz Zaman
Althea Medical Journal Vol 12, No 4 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/amj.v12n2.4307

Abstract

Background: Obesity is a major risk factor for knee osteoarthritis (KOA), contributing to pain, reduced joint function, and decreased quality of life. Hypertonic dextrose prolotherapy (HDP) has emerged as a potential treatment to lessen pain and improve function in KOA. This study aimed to observe the clinical outcomes of HDP injections in obese patients with KOA.Methods: A quasi-experimental study was conducted in 2023, involved obese patients diagnosed with KOA. Participants were divided into two groups: an intervention group receiving HDP injections and a control group receiving normal saline (NS) injections. Clinical outcomes were assessed using the Numeric Rating Scale (NRS) for pain and the Western Ontario and McMaster Universities Arthritis Index (WOMAC) before intervention, and at two and six weeks after intervention. Intergroup and intragroup mean differences were analyzed, with a significance value of p<0.05.Results: A total of 38 participants were included, with 20 assigned to the HDP group and 18 to the control group. Intragroup analysis showed a significant reduction in NRS scores in both groups (p<0.001), whereas no significant intragroup change was observed in WOMAC scores. Intergroup analysis showed significantly greater improvement in both NRS and WOMAC scores in the HDP group compared with the control group at two and six weeks after intervention (p<0.001).Conclusions: HDP injections improve clinical outcomes in obese patients with KOA, particularly in reducing pain intensity and improving functional status. Pain reduction may support participation in exercise and weight management programs, although persistent obesity may increase the risk of KOA recurrence.
Co-Authors Abdillah, Diaz Syafrie Aisyah Algristian, Hafid AS, Nur Azizah Donastin, Adyan HANDAYANI Mafruroh, Ilfia Hajar Putri, Mutiara Aswar Eka Rita Vivera Pane Silaban, Rusdiana Zulfikar, Mohammad Qoimam Bilqisthi Zurohidah, Aina