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All Journal International Islamic Medical Journal Medicor : Journal of Health Informatics and Health Policy
Abdillah, Diaz Syafrie
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Religion Humanities Health Professions Medicine & Pharmacology Public Health

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A Prophetic Medicine: Potential Therapeutic Effect of Nigella sativa for Osteoarthritis Al Hajiri, Aufar Zimamuz Zaman; Abdillah, Diaz Syafrie; Zulfikar, Mohammad Qoimam Bilqisthi
Jurnal Medis Islam Internasional Vol 1 No 2 (2020): June
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/iimj.v1i2.1622

Abstract

Osteoarthritis (OA) is the most common type of arthritis (inflammation of the joints). OA can affect all cartilage throughout the body, including the spine, but mainly attacks the legs from the pelvis, especially the knee to the ankle which affects about 10% of men and 18% of women over 60 years old. Pharmacotherapy, surgery, and complementary therapy are the currently managements of OA. Nigella sativa (NS) is one of the herbal plants which is part of the prophet's medicines in the Islamic world which still used. Thymoquinone (TQ) is one of NS compound, has an anti-inflammatory effect by inhibit the formation of eicosanoids in leukocytes and lipid peroxidation, or inhibit the expression of PF NF-κB subunits and p50 subunits with TNF-a promoters, and reduce levels of C-reactive protein (CRP). TQ also has a chondroprotective effects mechanism by decreases prostaglandin E2 (PGE) mediated by IL-1β and inhibits MMP synthesis in chondrocytes. Through its anti-inflammatory and chondroprotective effect, NS is a potential therapeutic agent which beneficial use for OA management without toxicological effects when given.
Addressing Self-Harm in Paranoid Schizophrenia: The Role of Supportive Psychotherapy in Primary Health Care Abdillah, Diaz Syafrie; Mumpuni, Yekti; Algristian, Hafid; Azizah, Nur; Khairunnisa
Medicor : Journal of Health Informatics and Health Policy Vol. 3 No. 4 (2025): October 2025
Publisher : Indonesian Scientific Publication

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.61978/medicor.v3i4.923

Abstract

Self-harm represents a serious psychiatric emergency frequently observed in individuals with schizophrenia, especially the paranoid subtype, where hallucinations, delusions, and comorbid depression play crucial roles. Although antipsychotic medications remain the cornerstone of treatment for symptom stabilization, they are often insufficient to address underlying psychosocial vulnerabilities that heighten self-harm risk. Supportive psychotherapy (SPT) has emerged as a cost-effective adjunctive intervention that can be integrated within primary health care to complement pharmacological treatment. This literature review synthesizes studies published between 2011 and 2025, retrieved from PubMed, ScienceDirect, and Google Scholar using the keywords paranoid schizophrenia, supportive psychotherapy, and self-harm. Findings reveal that SPT, when implemented after acute psychotic symptoms have subsided, enables patients to express emotions, receive reassurance, and modify maladaptive thoughts through supportive persuasion. Evidence indicates that SPT effectively reduces suicidal ideation and self-harm severity, commonly assessed using the Suicidal Intention Rating Scale (SIRS). Additionally, involving families and providing psychoeducation improve treatment adherence, reduce relapse rates, and create a more supportive home environment. Compared to structured psychotherapies such as cognitive behavioral therapy (CBT) or family-focused therapy (FFT), SPT is simpler, more flexible, and feasible in low-resource settings since it can be delivered by general practitioners with basic training. Overall, this review concludes that SPT offers significant potential to mitigate psychiatric emergencies and enhance the quality of life in paranoid schizophrenia patients at risk of self-harm. It recommends training primary care providers in SPT, integrating family psychoeducation, and implementing a stepped-care model that positions SPT as an initial stabilization phase before advancing to structured therapies.
Co-Authors Al Hajiri, Aufar Zimamuz Zaman Algristian, Hafid Khairunnisa Mumpuni, Yekti Nur Azizah Zulfikar, Mohammad Qoimam Bilqisthi