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All Journal Jurnal Kedokteran Brawijaya OISAA Journal of Indonesia Emas
Astuti Setyawardani
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Humanities Education Engineering Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Social Sciences

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ENHANCING THE POTENCIES OF CHIMERIC ANTIGEN RECEPTOR T CELL (CAR T CELL) BY CRISPR/CAS9 SYSTEM TO ERADICATE RETINOBLASTOMA Yehuda Tri Nugroho Supranoto; Muhammad Yuda Nugraha; Astuti Setyawardani
Jurnal PPI Dunia Vol 3 No 2 (2020)
Publisher : OISAA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52162/jie.2020.003.02.5

Abstract

Retinoblastoma (RB) is the most common primary intraocular malignancy of childhood. There is no therapies that can eradicate specifically the whole cancer cells without any side effects. The disialoganglioside 2 (GD2), one of the cancer’s cell markers that can be treated using immunotherapy, is expressed in RB. Through this fact, immunotherapy based on chimeric antigen receptor (CAR)-engineered T cells targeting cancer-specific antigens has shown great potential in treating this cancer. Although in recent studies show that immune cells are not able to destroy cancer cells because in every cancer cells there is protein programmed death ligand 1 (PD-L1). This literature review also shows the potential technology using Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR)-CRISPR associated protein (Cas9) method to silence PD-1 in CAR T cell, so PD-L1 can not deactivate CAR T Cell through PD-1 signaling. The combination using CAR T cell and CRISPR-Cas9 will be the great therapy to eradicate RB without any side effect.
Corneal Epithelial Damage Following Bacillus thuringiensis Bioinsecticide Exposure in Wistar Rats Komariah, Cicih; Astuti Setyawardani; Al Kamal, Ahmad Asrori; Nurul Amin, Aldi Nawaf; Hurriyyah, Hashinatul; Ulil Albab, Fathiah; Daeng Ndiko, Siti Aminah
Jurnal Kedokteran Brawijaya Vol. 34 No. 1 (2026)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Approximately 2% of bioinsecticides for pest control are biopesticides; 90% are Bt bioinsecticides, typically in spray form. Bt solution is acidic and may cause ocular surface damage. This study is conducted to determine the Bt exposure method and concentration that might cause corneal ocular surface damage. This study was performed on Wistar rats anesthetized with 75 mg/kg BW ketamine intraperitoneally, with these four treatments: 1. Bt Dipel WG solution exposure by filter paper with 0.5 g/L, 1 g/L, 2 g/L, and 4 g/L concentrations for 1 minute; 2. Bt Dipel WG solution exposure by filter paper with 6 g/L, 8 g/L, and 10 g/L concentrations for 1 minute; 3. 3 mL Bt Dipel WG solution exposure by drops for 2 minutes with 6 g/L, 8 g/L, and 10 g/L concentrations; and 4. 3 mL Bt Dipel WG solution exposure by drops for 2 minutes with 6 g/L, 8 g/L, and 10 g/L concentrations and eyelid closure for 30 minutes. Treatments 1, 2, and 3 were performed for 3 days; treatment 4 was performed for 7 days. Exposures were made on different rats. Corneal defects were identified using fluorescent liquid and blue penlight. Corneal ocular surface damage was evident in two Wistar rats exposed to 10 g/L Bt Dipel WG solution drops in the cornea with 30 minutes of eyelid closure for seven consecutive days. Bt bioinsecticide may cause corneal defects with exposures of 10 g/L and 30 minutes of eyelid closure for seven days.  
Co-Authors Al Kamal, Ahmad Asrori Cicih Komariah Daeng Ndiko, Siti Aminah Hurriyyah, Hashinatul Muhammad Yuda Nugraha Nurul Amin, Aldi Nawaf Ulil Albab, Fathiah Yehuda Tri Nugroho Supranoto