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All Journal Jurnal Kedokteran Brawijaya e-Journal Pustaka Kesehatan Jurnal Ilmu Kesehatan Masyarakat Indonesian Journal of Tropical and Infectious Disease Journal of Agromedicine and Medical Sciences Jurnal Respirologi Indonesia
Cicih Komariah
Fakultas Kedokteran Universitas Jember
Earth & Planetary Sciences Health Professions Library & Information Science Medicine & Pharmacology Public Health

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RISIKO KERUSAKAN HATI KARENA PARASETAMOL DALAM DOSIS TERAPI Komariah, Cicih
IKESMA Vol 3, No 2 (2007)
Publisher : FKM - UNEJ

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (136.366 KB)

Abstract

Paracetamol , a safe and effective drug that is commonly used and in many countries and is available as over the counter (OTC) preparation and hence dispensed by the pharmacist without a prescription. Paracetamol is widely used for the management of common cold, dysmennorhea, head ache, fever and pain. Because of its safety profile and cost, it is one of the preferred drugs and is used as a household remedy. This condition develop to the indicipline and misuse of paracetamol consumption. The studies that have been conducted by pharmacologist have proofen that the large dose, not regimen dose, of  paracetamol is safe to be consumed. They do not realize that paracetamol is a deadly painkiller, even at the recommended dose. Paracetamol poisoning is associated with many complications and may affect and hepatotoxicity is the major complication leading to death. The lack of knowledge on the part of patient on the side effects makes it dangerous for them to consume the drug. Without explicit warning on the packs of these drugs, it is putting the patient under severe risk pertaining to toxicity, particular the liver. This article try to describe that paracetamol consumption could intervere body health particularly the liver. Some case reports about liver damage after paracetamol ingestion also included to show that people must be aware  about the drug consumption even it is looks like safe and no harm for human body like paracetamol. It is ironic if the medicine we take to make us better just make us more suffer with other health problem which could be deadly. Keywords : paracetamol, recommended dose, liver damage
Hubungan Status Refraksi, dengan Kebiasaan Membaca, Aktivitas di Depan Komputer, dan Status Refraksi Orang Tua pada Anak Usia Sekolah Dasar Komariah, Cicih; A, Nanda Wahyu
Jurnal Kedokteran Brawijaya Vol 28, No 2 (2014)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (508.853 KB) | DOI: 10.21776/ub.jkb.2014.028.02.14

Abstract

Status refraksi seseorang dapat dipengaruhi oleh status faktor keturunan, kebiasaan membaca dan aktivitas di depan komputer. Penelitian ini bertujuan untuk mengetahui gambaran pola status refraksi, kebiasaan membaca, aktivitas di depan komputer, dengan status refraksi orang tua pada anak usia sekolah dasar. Penelitian dilakukan dengan survei pada siswa Madrasah Ibtidaiyah Khadijah kelas 4 sampai 6. Data tentang status refraksi orang tua serta kebiasaan membaca dan aktivitas di depan komputer siswa diperoleh dengan menggunakan kuesioner, sedangkan status refraksi siswa diperoleh dengan menggunakan lensa coba dan Snellen Chart. Hasil penelitian menunjukkan, aktivitas membaca dalam waktu lama dan pada jarak dekat, kemudian rutinitas berada di depan layar komputer dengan durasi waktu yang panjang banyak didapatkan pada siswa miopia. Sebagian besar siswa hiperopia dan miopia mempunyai orang tua dengan status refraksi yang sama. Pada sebagian besar siswa yang tidak berkaca mata, orang tuanya juga tidak berkaca mata. Kebiasaan membaca lama dan dekat, serta aktivitas di depan komputer yang lama banyak didapatkan pada status refraksi tertentu. Status refraksi siswa sebagian besar sama dengan status refraksi orang tuanya. Hasil mengindikasikan hubungan pola kebiasaan membaca dan penggunaan komputer serta status refraksi orang tua dengan status refraksi anak.Kata Kunci: Aktivitas di depan komputer, kebiasaan membaca, status refraksi anak, status refraksi orang tua
Efek Analgesik Kombinasi Kurkumin dan Parasetamol pada Mencit yang Diinduksi Asam Asetat menggunakan Isobologram (The Analgesic Effect of Combination of Curcumin and Paracetamol in Acetic acid-induced Mice using Isobolograms) Nugroho Priyo Utomo; Cicih Komariah; Yudha Nurdian
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Paracetamol is a drug that classified as NSAID and commonly used as analgesic agent. These drugs have toxic effects that lead to liver damage. This effects caused by accumulation the metabolite compound of paracetamol, N-acetyl-p-benzoquinone (NAPQI), by cytochrome P450 enzyme. Some studies reported that curcumin have analgesic effects and inhibit action of cytochrome P450 enzyme. The purpose of this study was to determine the analgesic effect of curcumin and paracetamol combination in 27 acetic-acid induced mice. The result of this study showed that 2358,815 µg of curcumin and paracetamol combination can inhibit pain up to 50%. This result is smaller than paracetamol that need 4200 µg to achieve the same pain inhibition. One Way Annova test showed siginificant difference between paracetamol group and combination group. Isobolographic analysis results showed curcumin and paracetamol have synergistic properties in mice acetic-acid induced pain. Keywords: curcumin, paracetamol, isobolograph
Hubungan Sanitasi Lingkungan dengan Kejadian Infeksi Soil Transmitted Helminths pada Anak Sekolah Dasar di Jember Nur Aqmarina Kusumawardani; Erma Sulistyaningsih; Cicih Komariah
Pustaka Kesehatan Vol 7 No 1 (2019): Volume 7 No. 1, 2019
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v7i1.17591

Abstract

Poor environmental sanitation is suspected to be one of the causes of soil transmitted helminthes (STH) infection. Environmental sanitation consists of water sources, latrine, sewerage, garbage disposal facilities, and floor type. The objective of this study was to investigate the relationship between environmental sanitation and the incidence of STH infection in primary school children. This was an observational analytic study with cross-sectional design. The subjects were 80 students of two elementary schools in Jember. Stool samples were collected and examined by Kato-Katz method. Data of environmental sanitation was collected by questionnaire and direct observation. Kato-Katz examination showed that 9 samples (11,3%) infected by Ascaris lumbricoides. The majority respondents had not fulfilled requirements of good environmental sanitation. The result of Spearman test showed that there was a significant correlation between STH infection and latrine (p=0,02) but there were no significant relationship between STH infection and environmental sanitation (p = 0.165), gender (p = 0,669), age (p = 0,92), water source (p = 0.084), sewerage (p = 0.146), garbage disposal facilities (p = 0,728), and floor type (p = 0,065).
Efek Ekstrak Kulit Mangga Arumanis terhadap Penurunan Edema Kaki Mencit Putih Jantan yang Diinduksi Karagenin Ongky Dyah Anggraini; Cicih Komariah; Aris Prasetyo
Pustaka Kesehatan Vol 6 No 2 (2018)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/pk.v6i2.7666

Abstract

Mango is a plant contains many active compounds with health benefits. Total phenolic content of mango peel is higher than mango flesh, with its major component are mangiferin and quercetin. Quercetin has anti-inflammatory effects through the inhibition of inflammatory mediators are serotonin, bradykinin, histamine and prostaglandin, possibly could reduce oedema as a sign of inflammation. This study used carrageenin to induce inflammation by making paw oedema in mice. The aim of this research was to know the effect of arumanis mango peel extract to reduce paw oedema in white male mice. The was quasi experimental study with 7 study groups. Spearman analyses showed a correlation with significance of (p= 0.003) that mean it has a significant correlation (p <0.01) at the 330th min. Spearman correlation coefficients was 0,632, indicated that the dose of extract and paw oedema have strong correlation. It can be concluded that mango peel extract has effect for reducing paw oedema in white male mice, with the smallest dose was 1,002mg / gBW. Keywords: mango, quercetin, paw oedema
Daya Antibakteri Kombinasi Kitosan Cangkang Udang Putih (Litopenaeus vannamei) dan Siprofloksasin terhadap Salmonella typhi (Antibacterial Activity of Combination of White Shrimp (Litopenaeus vannamei) Shells Chitosan and Ciprofloxacin against Salmonella Sarah Marsa Tamimi; Dini Agustina; Cicih Komariah
Pustaka Kesehatan Vol 5 No 2 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

yphoid fever is an acute infectious disease in the intestinal tract caused by Salmonella typhi. The prevalence of typhoid fever in Indonesia in 2013 was 81% per 100,000 population. Ciprofloxacin is a large-spectrum antibiotics, but in some countries ciprofloxacin has been known to be resistant to S. typhi. Therefore, other methods are needed to improve the effectiveness of ciprofloxacin by combining with chitosan. Chitosan is a polysaccharide which known to be effective in some positive and negative Gram bacteria and able to overcome the resistance of some antibiotics. The research objective was to determine the effect of antibacterial and Minimum Inhibitory Concentration (MIC) of the combination of Litopenaeus vannamei chitosan and ciprofloxacin against S. typhi. The method used to obtain the value of the MIC was microdilution method with quasy-experimental research design and posttest only control group design. MIC which already been obtained then used to find the Fractional Inhibitory Concentration Index (FICI) using a checkerboard test to interpret the effect of the combination. The MIC combination showed different results in each repetition that chitosan: 15.63 to 62.5 µg/mL and ciprofloxacin from 0.03 to 0.5 µg/mL and known to have a smaller value than the MIC single. While the value of FICI from 5 repetitions was 0.476. So, it could be concluded that the combination of chitosan and ciprofloxacin has an antibacterial effect on S. typhi and have a synergistic combination effect. Keywords: Salmonella typhi, chitosan, ciprofloxacin, microdilution method, checkerboard test.
Efek Ekstrak Kulit Mangga (Mangifera indica L.) Arumanis terhadap Lama Perdarahan Mencit Putih Jantan (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Bleeding Time of White Male Mice) Komang Dewi Fridayanti; Cicih Komariah; Jauhar Firdaus
Pustaka Kesehatan Vol 5 No 1 (2017)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

The inhibition of cyclooxygenase 1 (COX-1) enzyme leads to the decrease of tromboxane A2 (TXA2) and decrease the activity of platelet aggregation that marked by the lengthening of bleeding time. This mechanism is important to prevent the occurence of patology that can lead to thrombosis. Flavonoid, polyphenol present in the mango peel, is known to have activity for blocking the COX-1 enzyme. The aim of this research was to know the effect of Arumanis mango peel extract for lengthening the bleeding time on white male mice. The research was true experimental. The sampel was treated for seven days and the bleeding time was measured on the seventh day. The result of analyses Kruskal Wallis shows that there are significant difference intern-treatment group with significance (p) 0.033. The Mann Whitney analyses test shows significant difference between treatment group 2 (P2), treatment group 4 (P4), treatment group 5 (P5) and negative control group (K-). So, it can be concluded that arumanis mango peel extract can lengthening the bleeding time of white male mice.The dosis of 16,8 mg.grBBof mango peel extract givesthe longest mean bleeding timeand it exceeds the mean of positive control group. Keywords: bleeding time, mango, flavonoid
Efek Ekstrak Kulit Mangga Arumanis (Mangifera indica L.) terhadap Paw Licking Time Mencit Putih Jantan yang Diinduksi Formalin (The Effect of Arumanis Mango (Mangifera indica L.) Peel Extract on the Paw Licking Time in White Male Mice Induced by Formalin Rosita Sopwi Nur Lailly; Cicih Komariah; Rosita Dewi
Pustaka Kesehatan Vol 4 No 3 (2016)
Publisher : UPT Percetakan dan Penerbitan Universitas Jember

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Abstract

Mango is one of the plants which have a lot of benefits in pharmacology. Total phenol in its peel is higher than in its flesh with the main component is mangiferin and quercetin which known have activity to inhibit cyclooxygenase 2 (COX-2) enzyme. The inhibition of COX-2 leads to the decrease of the production of prostaglandin (PgE2) so it can reduce pain which marked by the decrease of paw licking time on mice induced by formalin. Formalin-induced pain is divided into two phase: early phase at 0-5th minutes and late phase at 15-30th minutes. The aim of this research was to know the effect of Arumanis mango peel extract to decrease the paw licking time in white male mice. The research design was true experimental. The result of analyses used One Way Anova shows that there were significant difference in each treatment groups with significance p < 0,05. The LSD analysis on late phase showed no significant difference between the fifth treatment group and the positive control group in LSD test. It can be concluded that arumanis mango peel extract has equal effect with natrium diclofenac in decreasing paw licking time on late phase in dosage 26 mg/g. Keywords: mango peel, paw licking time, flavonoid
RISIKO KERUSAKAN HATI KARENA PARASETAMOL DALAM DOSIS TERAPI Cicih Komariah
Jurnal Ilmu Kesehatan Masyarakat Vol 3 No 2 (2007)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Paracetamol , a safe and effective drug that is commonly used and in many countries and is available as over the counter (OTC) preparation and hence dispensed by the pharmacist without a prescription. Paracetamol is widely used for the management of common cold, dysmennorhea, head ache, fever and pain. Because of its safety profile and cost, it is one of the preferred drugs and is used as a household remedy. This condition develop to the indicipline and misuse of paracetamol consumption. The studies that have been conducted by pharmacologist have proofen that the large dose, not regimen dose, of  paracetamol is safe to be consumed. They do not realize that paracetamol is a deadly painkiller, even at the recommended dose. Paracetamol poisoning is associated with many complications and may affect and hepatotoxicity is the major complication leading to death. The lack of knowledge on the part of patient on the side effects makes it dangerous for them to consume the drug. Without explicit warning on the packs of these drugs, it is putting the patient under severe risk pertaining to toxicity, particular the liver. This article try to describe that paracetamol consumption could intervere body health particularly the liver. Some case reports about liver damage after paracetamol ingestion also included to show that people must be aware  about the drug consumption even it is looks like safe and no harm for human body like paracetamol. It is ironic if the medicine we take to make us better just make us more suffer with other health problem which could be deadly. Keywords : paracetamol, recommended dose, liver damage
KORELASI PROGRAM PENGELOLAAN PENYAKIT KRONIS BADAN PENYELENGGARA JAMINAN SOSIAL KESEHATAN TERHADAP KUALITAS HIDUP PASIEN di UNEJ MEDICAL CENTER Ida Srisurani Wiji Astuti; Adhang Isdyarsa; Cicih Komariah
Jurnal Ilmu Kesehatan Masyarakat Vol 14 No 1 (2018)
Publisher : Fakultas Kesehatan Masyarakat, Universitas Jember

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19184/ikesma.v14i1.10403

Abstract

Prolanis BPJS (the program of Chronic Disease Management by Social Security Health Agency) was launched for financing efficiency for chronic disease in Indonesia. The efficiency has made a noticeable impact.This study aims to observe the correlation between the program and the increase of patients’ quality of life as a result of the implementation of Prolanis BPJS. The research deployed cross sectional analytic approach in which data was collected in January 2017.During the research, 2 (two) types of questionnaire such as questionnaire of service quality based on the SERVQUAL (Service Quality) and the SF-36 questionnaire related to the quality of life were distributed. A total of 22 respondents were involved through total sampling method to identify both the value of perception and expectations of each respondent towards the quality of primary health care facilities in Unej Medical Center. Spearman method was implemented for data analysis reportingthe findings that in general the quality of service provided by PROLANIS BPJS indicated no correlation with the patients’ quality of life at UMC (p) 0,072,and (r) 0,391. Eight dimensions of life quality were examined, and only two of them were showed correlation with the quality of service provided, namely: the dimensions of physical function and bodily pain
Co-Authors Adhang Isdyarsa Ainindya Pasca Rachmadiani Angga Mardro Raharjo, Angga Mardro Cahyaningrum, Endiningtyas Cholis Abrori, Cholis Desie Dwi Wisudanti Dini Agustina Dwisaraswati, Salma Aulia Dwita Aryadina Rachmawati Elly Nurus Sakinah, Elly Nurus Ema Fawziyah Ulfah Erma Sulistyaningsih Gama Wisnu Sanjaya Hasbi Maulana Arsyad Hidayat Sujuti Ida Srisurani Wiji Astuti Jauhar Firdaus Komang Dewi Fridayanti M. Ali Shodikin Maulidiyah, Najma Ma’sum Effendi Muhamad Hasan Nanda Wahyu A Novail Alif Muharrom Nugroho Priyo Utomo Nur Aqmarina Kusumawardani Ongky Dyah Anggraini Prasetyo, Aris Putra, Yudha Ananta Khaerul Rosita Dewi Rosita Sopwi Nur Lailly Rumastika, Nindya Shinta Sarah Marsa Tamimi Semita, I Nyoman septa surya wahyudi, septa surya Sheilla Rachmania, Sheilla Supangat Supangat Suryono Suryono Ulfa Elfiah Yudha Nurdian