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All Journal International Journal of Natural Science and Engineering Jurnal Kesehatan Gigi (Dental Health Journal)
Supariani, Ni Nyoman Dewi
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Dentistry Engineering

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Journal : International Journal of Natural Science and Engineering

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Effectiveness of Giving Chitosan on Interleukin-6 and Mallondhyaldehide Levels in Wistar Rats with Chronic Periodontitis Dharmawati, I Gusti Agung Ayu; Mastra, Nyoman; Supariani, Ni Nyoman Dewi; Ratih, Gusti Ayu Made; Artini, Ni Putu Rahayu
International Journal of Natural Science and Engineering Vol. 7 No. 1 (2023): April
Publisher : Lembaga Penelitian dan Pengabdian kepada Masyarakat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23887/ijnse.v7i1.53897

Abstract

The 6th highest diseases that occur in Indonesian society include dental caries and periodontitis caused by dental plaque which is a breeding ground for bacteria such as Streptococcus mutants and Phorphyromonas gingivalis. The purpose of this study was to determine the effectiveness of chitosan on levels of Interleukin-6 and Malondhyaldehyde (MDA), as an anti-inflammatory marker using the Elisa test. The research method was a true experimental randomized posttest only control group design, with 3 treatment groups namely control, 2% chitosan gel, and 100mg/200g/bb of chitosan orally in 15 Wistar rats with periodontitis induced by Phorphyromonas gingivalis bacteria. The results showed that the mean levels of Interleukin-6 and Mallondhyaldehyde were significantly different (p<0.05) between the control group, chitosan gel treatment, and oral chitosan administration Interleukin-6 levels were the highest in the chitosan gel (8.3091±1.25570), the control average (5.8523±0.51512), the lowest oral average (3.2563±1.45952). Similarly, Mallondhyaldehyde levels were highest in the gel group (2.8850±0.19353), control group (2.2284±0.00914), and oral group (1.2943±0.60280).). Based on these results, oral chitosan was the most effective in the treatment of periodontitis.
Co-Authors Anak Agung Gede Agung, Anak Agung Gede Fadila, Yulastri I Gusti Agung Ayu Dharmawati mastra, nyoman Ni Putu Rahayu Artini Ni Wayan Arini Pradnyaswari, Putu Intan Ratih, Gusti Ayu Made Sari, Ayu Made Putri Kartika Senjaya, Asep Arifin Sirat, Ni Made Wirata, I Nyoman