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All Journal Obstretika Scientia Indonesian Journal of Pharmacology and Therapy
Setyo Purwono
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Humanities Education Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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ROSELA (HIBISCUS SABDARIFFA) MENCEGAH KENAIKAN TEKANAN NADI KENAIKAN MALONDIALDEHIDE DAN MENINGKATKAN STATUS ANTIOKSIDAN TOTAL TIKUS YANG DIINDUKSI ALKOHOL Budi Siswanto; Denny Agustiningsih; Setyo Purwono
Jurnal Obstretika Scientia Vol 2, No 1 (2014)
Publisher : Akademi Kebidanan La Tansa Mashiro

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (663.019 KB) | DOI: 10.55171/obs.v2i1.121

Abstract

Oxidative stress can cause coronary heart disease. This research aims to study the effect of steeping rosella flower petals showed differences in pulse pressure, plasma MDA and SATs in the blood of rats fed 20% alcohol dose 4 grams/kg body weight/day as a trigger of reactive oxygen species. Thirty male wistar rats at least 150 grams of body weight divided into five groups, each group of six rats. Group A was given boiled water, group B was given alcohol, groups C, D and E are given alcohol and rosella. Dose of 0.75 grams rosella rosella in 200 cc of the water brewing given to kelompom C, while group D rosella dose 1.5 g and E 3 gr. Giving rosella and alcohol for 70 days by way of the sonde. Rosella alcohol given at 7:00 and 11:00 hours. Pulse pressure, plasma MDA and plasma levels of SAT were measured before and after treatment. The results showed that pulse pressure, plasma MDA steeping rosella groups given 0.75 g, 1.5 grams and 3 grams of lower and higher SAT levels compared with groups given alcohol alone. Conclusion rats fed steeping rosella flower petals and alcohol pulse pressure, lower levels of plasma MDA and higher SAT levels compared with groups that were given alcohol alone.
Animal models in antihypertensive drug development research Dwi Aris Agung Nugrahaningsih; Mia Munawarroh Yuniyanti; Rahmi Ayu Wijayaningsih; Mosa Rini Nurul Hidayati; Setyo Purwono
Indonesian Journal of Pharmacology and Therapy Vol 1 No 2 (2020)
Publisher : Faculty of Medicine, Public Health, and Nursing Universitas Gadjah Mada and Indonesian Pharmacologist Association or Ikatan Farmakologi Indonesia (IKAFARI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/ijpther.585

Abstract

Hypertension is one of the most common diseases in the world. However, its pathogenesis is not fully understood and its treatment is not yet satisfying. Animal models of hypertension have been useful to understand the pathogenesis of hypertension and to test novel therapeutic agents. There are several kinds of hypertension animal models. Each model has different characteristics. Knowing the characteristic of each model is important to obtain valid research. This review will describe several available methods to develop animal model for hypertension.
Co-Authors Budi Siswanto Denny Agustiningsih Dwi Aris Agung Nugrahaningsih Mia Munawarroh Yuniyanti Mosa Rini Nurul Hidayati Rahmi Ayu Wijayaningsih