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All Journal Jurnal Kedokteran Brawijaya Majalah Kedokteran Bandung Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Biology, Medicine, & Natural Product Chemistry Mutiara Medika: Jurnal Kedokteran dan Kesehatan Jurnal Keperawatan Respati Yogyakarta Viva Medika: Jurnal Kesehatan, Kebidanan dan Keperawatan South East Asia Nursing Research Muhammadiyah Journal of Geriatric Berita Kedokteran Masyarakat Obstretika Scientia

Denny Agustiningsih

Faculty Of Medicine, Public Health And Nursing, Gadjah Mada University, Yogyakarta

Author-ID : 2506135

Humanities Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health

Published : 14 Documents Claim Missing Document

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Effect of swimming and asthmatic exercise on forced expiratory volume in 1 second (FEV1) and levels of cortisol hormone in asthmatics patients Achmad Djunaedi, Rahmaya Nova Handayani, Denny Agustiningsih
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 44, No 01 (2012)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (210.948 KB)

Bronchial asthma is one of the allergic diseases characterized by reversible bronchial narrowing dueto bronchial hyperactivity and obstruction of respiratory tract. The prevalence and hospitalizationrates of bronchial asthma keep increasing from year to year, causing asthma to be the top ten causesof morbidity and mortality in Indonesia. The decrease of the forced expiratory volume in 1 second(FEV1) is one of the indicators of the respiratory tract obstruction. Moreover, the cortisol hormonelevel is also associated with asthma. Asthma can be treated not only with pharmacological interventionbut also physical exercises. The aim of the study was to assess the increase of FEV1 and cortisolhormone level after swimming and asthmatic exercise on asthmatic patients. This was a quasiexperimental study using pre and post test control group design. Two groups of 10 asthmaticpatients each conducted swimming and asthmatic exercise as intervention. On pre, middle and postswimming or asthmatic exercise, those two groups underwent the measurement of FEV1 using aspirometer and cortisol hormone levels using ELISA methods. The result showed that the value ofFEV1 and cortisol hormone levels increased significantly after swimming and asthmatic exercise(p<0.05). Moreover, the improvement of FEV1 value and cortisol hormone levels of asthmaticpatients in swimming were higher than asthmatic exercise. In conclusion, swimming and asthmaticexercise can increase the value of FEV1 and the levels of the cortisol hormone.Keywords : swimming - asthmatic exercise - FEV1 - cortisol hormone - asthma

Moderate-intensity interval exercise but not high-intensity interval exercise improves the spatial memory of ovariectomized rats Kaidah, Siti; Rauf, Saidah; Soesatyo, Marsetyawan HNE; Agustiningsih, Denny; Partadiredja, Ginus
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 50, No 3 (2018)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

Physical exercise exerts beneficial effects on the spatial learning and memory. High-intensity interval exercise (HIIE) has been proposed as a time-efficient physical exercise regimen. On the other hand, there were evidences that HIIE increased oxidative stress biomarkers and reduced antioxidant capacity, which resulted in oxidative damage. The present study aimed to investigate the effects of high-intensity interval exercise and moderate-intensity interval exercise on oxidative stress biomarkers and oxidative enzymes activity in the hippocampus and the spatial memory of ovariectomized rats. A total of 16 female Sprague Dawley rats aged 12 weeks were randomly assigned into 4 groups, i.e. the sham-operated (SO), ovariectomized without exercise (O), ovariectomized with high-intensity interval exercise (HIIE), and ovariectomized with moderate-intensity interval exercise (MIIE) groups. Rats of the exercise groups (HIIE & MIIE groups) performed 6 sessions of interval exercise per week for 6 weeks. The spatial memory of rats was measured using the Morris water maze procedure. The malondialdehyde (MDA) levels and activity of catalase (Cat) as well as glutathione peroxidase (GPx) in hippocampus were determined using spectrophotometry method. The spatial learning and memory retention of the moderate-intensity interval exercise group was significantly better than that of the high-intensity interval exercise group. The GPx activity of MIIE group was higher than any other groups. The SO group had the lowest hippocampal MDA level and highest Cat activity among groups. Moderate-intensity interval exercise reduces the ovariectomy induced-oxidative stress in the hippocampus and improves spatial learning and memory retention of ovariectomized rats.

Rosuvastatin Attenuated Elastic Fiber Degradation in Chronic Obstructive Pulmonary Disease Sprague-Dawley Rats Sabirin, Rahmaningsih Mara; -, Prasetyastuti; Agustiningsih, Denny
Jurnal Kedokteran Brawijaya Vol 30, No 3 (2019)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Chronic obstructive pulmonary disease (COPD) is an incurable disease which causes disability and death. The main pathogenesis of COPD is oxidative stress due to cigarette smoke which initiates various reactions and lead to lung elastic fibers destruction. Statins are known to have antioxidant effects and reduce mortality in COPD. We studied the effects of cigarette smoke exposure cessation and rosuvastatin on oxidative stress and the level of elastic fiber destruction in COPD model rats. Thirty 10-week old male Sprague-Dawley rats were divided into 2 groups: Control (n=6, did not received fumigation nor treatment) and Smoking (n=24, received fumigation for 70 days) groups. Afterwards, the smoking group was divided into 4 groups: Sham, R2, R5,R10, and received 0.9% NaCl, 2.5, 5 and 10 mg/kg/day of rosuvastatin, respectively. Examination of malondialdehyde (MDA) and desmosine serum were conducted to measure oxidative stress and elastic fiber degradation level, respectively. After smoke exposure, MDA and desmosine levels of COPD rats were found to be significantly higher (p=0.000 and 0.000) than controls. The MDA level in Sham, R2, R5 and R10 groups decreased significantly after therapy (p=0.000; 0.033; 0.015; 0.002). However, the post-treatment desmosine level was increase significantly in Sham and R2 groups (p=0.006 dan 0.012) and insignificantly (p=0.117 dan 0.278) in the R5 and R10 groups. It can be concluded that the cessation of exposure to cigarette smoke can reduce oxidative stress, but not elastic degradation process. The administration of rosuvastatin of 5 or 10 mg/kg/day attenuated elastic degradation process.

Gambaran Faktor Risiko Prolaps Organ Panggul Pasca Persalinan Vaginal di Daerah Istimewa Yogyakarta Pangastuti, Nuring; Sari, Dwi Cahyani Ratna; Santoso, Budi Iman; Agustiningsih, Denny; Emilia, Ova
Majalah Kedokteran Bandung Vol 50, No 2 (2018)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Prolaps organ panggul merupakan salah satu bentuk disfungsi dasar panggul pada perempuan. Disfungsi dasar panggul adalah keadaan terganggunya fungsi dasar panggul merupakan salah satu kondisi kesehatan yang banyak dikeluhkan perempuan. Lebih dari 46% perempuan dengan riwayat persalinan vaginal mengalami disfungsi dasar panggul,dan peningkatan jumlah paritas berkorelasi dengan peningkatan kejadian prolaps organ panggul. Tujuan penelitian ini adalah untuk mengetahui gambaran karakteristik faktor risiko prolaps organ panggul pasca persalinan vaginal di wilayah Daerah Istimewa Yogyakarta. Penelitian dilakukan pada Januariâ€“Maret 2018. Hasil penelitian didapatkan 51 subjek penelitian dengan persalinan vaginal yang dapat dilakukan pemeriksaan POPQ pada 3 bulan pascapersalinan. Prolaps organ panggul didapatkan pada sebagian besar pasien pascasalin, yaitu sejumlah 46 orang, prolaps uteri 33 orang, sistokel 44 orang, serta rektokel pada 46) orang. Hanya 5 orang yang tidak memiliki gambaran prolaps organ panggul pada 3 bulan pascapersalinan.Dari penelitian ini dapat disimpulkan bahwa faktor risiko prolaps organ panggul pascapersalinan vaginal di Daerah Istimewa Yogyakarta terdiri atas faktor intrinsik (usia ibu, panjang genital hiatus maupun perineal body), dan ekstrinsik (paritas, indeks massa tubuh overweight dan obes, kenaikan berat badan selama hamil >15 kg, serta dilakukan episiotomi dan terjadi robekan perineum). Upaya pencegahan terutama edukasi, perbaikan gaya hidup, pengendalian indeks massa tubuh, pengaturan diet, olahraga penguatan otot dasar panggul, pembatasan jumlah kehamilan dan persalinan, serta pertolongan persalinan sesuai Asuhan persalinan normal.Â Kata kunci: Disfungsi dasar panggul, faktor risiko, persalinan vaginal, prolaps organ panggulÂ Risk Factors for Pelvic Organ Prolapse in Women with History of Vaginal Delivery in YogyakartaPelvic organ prolapse is one form of pelvic floor dysfunctions in women that impairs the pelvic floor function and also one of the most frequently conditions complained by women. More than 46% women with history of vaginal delivery have experienced pelvic floor dysfunction where higher number of parity correllates to increased pelvic organ prolapse incident. The aim of this study was to understand theÂ characteristic risk factors of pelvic organ prolapse incident post vaginal delivery in Special Region of Yogyakarta. The study ws performed during the period of January to March 2018 on 51 subjects with history of vaginal delivery evaluated using POPQ in 3 months postpartum. Pelvic floor dysfunction was present in most postpartum patients, i,e, 46 people while 33 experienced uterine prolapse, 44 experienced cystocele, and 46 experienced rectocele. Only 5 subjects had no pelvic floor dysfunction in any form. Risk factors for pelvic organ prolapse in post vaginal delivery in the Special Region of Yogyakarta consist of intrinsic factors (maternal age, genital length of hiatus, and perineal body), and extrinsic factors (parity, overweight status and obese status based on body mass index, weight gain during pregnancy exceeding 15 kg,Â episiotomy and the occurrence of perineal rupture). Prevention actions includeÂ education followed by lifestyle improvement, control of body mass index, dietary regulation, exercise, restrictions on the number of pregnancies and childbirth, and safe delivery according to normal birth care standard.Key words: Pelvic floor dysfunction, pelvic organ prolapse, risk factors, vaginal delivery

Validation test of Indonesian pelvic floor distress inventory-20 (Indonesian PFDI-20) Pangastuti, Nuring; Iman, Santoso Budi; Denny, Agustiningsih; Emilia, Ova
Journal of the Medical Sciences (Berkala Ilmu Kedokteran) Vol 52, No 2 (2020)
Publisher : Journal of the Medical Sciences (Berkala Ilmu Kedokteran)

The pelvic floor distress inventory-20 (PFDI-20) questionnaire is one of the questionnaires used to help find out complaints of pelvic floor dysfunction. The questionnaire is also frequently used in studies related to pelvic floor dysfunction. The validation test results of the questionnaire have not been obtained from Indonesian population.This study aimed to obtain an Indonesian PFDI-20 questionnaire that is in accordance with the original questionnaire and valid as well as reliable use for the Indonesian population.The validation test series were conducted through several stages: forward translation, back-translation, expert panel, pre-testing, and cognitive interviewing, final version and documentation. Data of 77 female respondents of reproductive age in the Yogyakarta Special Region were collected from January to March 2018.The statistical test result of questionnaire validity from the corrected item-total correlation of each question item has value more than 0.30 (0.385-0.781) indicating that the Indonesian PFDI-20 questionnaire was valid. Test reliability of the questionnaire using Cronbach’s alpha with a high significant result of 0.911 (0.902-0.913)> r table was obtained. In conclusion, the Indonesian PFDI-20 questionnaire is valid and reliable, thereforeit can be used in Indonesian population.

The Influence of Dry Cupping toward Heart Rate Variability (HRV) in Male Obesity adolescence Syahruramdhani, Syahruramdhani; Agustiningsih, Denny; Sofro, Zaenal Muttaqien
Mutiara Medika: Jurnal Kedokteran dan Kesehatan Vol 16, No 2: July 2016
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18196/mmjkk.v16i2.5137

Cardiovascular disease defines as a disease related to heart and blood vessel. One of high risk in the disease of cardiovascular is its on people with obesity. Heart Rate Variability (HRV) indicator is an important sign to identify cardiovascular risk and provide early information related to change of heart autonomy controlling. This indicator was influenced by several factors such as cupping therapy. Study found that HRV increased after cupping therapy by wet cupping treatment in healthy people. The aims of this research is to investigate the influence of dry cupping toward increased HRV in male obesity adolescence. The study was experimental with pre-post test design by using consecutive sampling of 30 male adolescence aged 18-24 years old with BMI 25 kg/m2. They were divided into 2 groups, control and intervention group with cupping therapy. Data result used in SDDN and RMSSD level. Analysis Data were used paired and independent t test. The result showed SDNN and RMMSD level before intervention were 73,95 ms dan 67,11 ms. Whereas SDNN and RMMSD level after intervention were 69,66 ms dan 61,95 ms. In paired (p=0,52 and p=0,38) and independent t test (p=0,30 and p=0,56) showed that there were no significant difference between SDNN and RMSSD in intervention group and control group (p 0,05). The conclusion of this study is dry cupping had no effects toward increased HRV level in male obesity adolescence.

PENGARUH LATIHAN RENANG TERHADAP KADAR HORMON KORTISOL PADA PENDERITA ASMA Rahmaya Nova Handayani; Denny Agustiningsih; Achmad Djuneadi
Viva Medika Vol 7 No 1 (2014)
Publisher : Universitas Harapan Bangsa Purwokerto

Bronchial asthma is one of allergic disease and a health problem both in developedcountries and in developing countries characterized by reversible narrowing of the bronchi due tobronchial hyperactivity . The prevalence and hospitalization rates of bronchial asthma indeveloped countries from year to year tend to increase. One of the triggers of asthma is stress.Stress is closely related to a hormone called glucocorticoids . Glucocorticoids which regulatesmetabolism and resistance to stress , including cortisol , corticosterone and cortisone .Glucocorticoids can potentially respond kotekolamin the bronchial tissue , occurs only atconcentrations influence physiology . This suggests cortisol has a role in affecting airway tone in individuals.The purpose of this study was mengidentifikasipengaruh swimming against cortisol levels in patients with asthmaThe design of this study is a quasi experimental study with pre-post study design -test group design . Measurement of cortisol levels do in the beginning , middle and end of thetreatment pool exercises were performed 1 week 3 times in the morning with a sample of 20respondents . Cortsisol hormonal measurements done using ELIZA measurement , the blood of therespondents were taken before and after swimming practice . People with asthma are taken by amedical diagnosis is determined by the doctor at the health center Brits with the male genderThe result of this research is there before and after the effect of swimming exercise on cortisollevels in patients with asthma . Keywords : Pool , cortisol , asthma

PENGARUH SENAM ASMA TERHADAP PENINGKATAN FORCED EXPIRATORY IN 1 SECOND (FEV 1) PADA PENDERITA ASMA Rahmaya Nova Handayani; Denny Agustiningsih; Achmad Djuneadi
Viva Medika Vol 7 No 2 (2014)
Publisher : Universitas Harapan Bangsa Purwokerto

Asthma is a disorder such as chronic inflammation of the airways that causes hyperactivity of thebronchi to various stimuli which is characterized by symptoms of recurrent episodic form of wheezing , coughing , shortness of breath and tightness in the chest , especially at night or earlymorning are generally reversible either with or without treatment. Asthma fluctuated ( intermittent) means it can be quiet without symptoms , but can not interfere with the activities developed mildto severe symptoms can even cause death . One indication of obstruction in the respiratory tract isForced expiratory volume in 1 second ( FEV1 ) decreased . Forced expiratory volume in 1 secondis the amount of air that is expelled as soon as possible in the first second after taking the deepest breath. The purpose of this study was to determine the effect of asthma gymnastics to increasedFEV1 in patients with asthma . The design of this study is a quasi experimental study with pre-post study design -test group design . FEV1 measurements made at the beginning , middle and endof the treatment of asthma gymnastics performed 1 week 3 times in the morning with a sample of20 respondents . Gymnastics asthma conducted every Tuesday , Thursday and Saturday at 07.00 pm for 12 weeks . FEV1 measurements done using sprirometri brand " Autospiro AS - 505 "Minato Japanese production . People with asthma are taken by a medical diagnosis is determined by thedoctor at the health center Brits with the male gender .The result of this study is therebefore and after the effect of asthma gymnastics to increased FEV1 in patients with asthma . Keywords : Gymnastics asthma , FEV1 , asthma

Latihan Pernapasan dengan Metode Buteyko Meningkatkan Nilai Force Expiratory Volume In 1 Second (%Fev1) Penderita Asma Dewasa Derajat Persisten Sedang Denny Agustiningsih, Abdul Kafi, Achmad Djunaidi
Berita Kedokteran Masyarakat (BKM) Vol 23, No 2 (2007)
Publisher : Fakultas Kedokteran Universitas Gadjah Mada

Background: Breathing exercises are frequently recommended as an adjunctive treatment for asthma. Breathing exercise for asthma that is recommended in Indonesia is Senam Asma Indonesia, which has a session of aerobic exercise. In Russia and Australia Buteyko method is practiced as a simple exercise for respiration. Principally, the technique of Buteyko is different from other respiration methods.Objective: The aim of this study is to know if the effect of Buteyko method could increase lung function of adult asthmatic patient better than Senam Asma Indonesia.Methods: Design of this study is field experiment with pretest and posttest of the lung function test (FVC, %FVC, FEV1 and %FEV1). The subjects divided into three groups, the group I, given exercise with the Buteyko method, group II given exercise with Senam Asma Indonesia and the group III without any exercise. The exercise was given for 12 weeks. The lung function test was done at the end of every month for all groups.Result: %FEV1 for Buteyko’s group increased significantly but other parameters didn’t.Conclusion: Breathing exercises with Buteyko and Senam Asma Indonesia both could decrease the airway resistance in asthmatic patient, but could not improve the vital capacity of the lung.Keywords: asthma; buteyko method, senam asma Indonesia, lung function test

ROSELA (HIBISCUS SABDARIFFA) MENCEGAH KENAIKAN TEKANAN NADI KENAIKAN MALONDIALDEHIDE DAN MENINGKATKAN STATUS ANTIOKSIDAN TOTAL TIKUS YANG DIINDUKSI ALKOHOL Budi Siswanto; Denny Agustiningsih; Setyo Purwono
Jurnal Obstretika Scientia Vol 2, No 1 (2014)
Publisher : Akademi Kebidanan La Tansa Mashiro

Oxidative stress can cause coronary heart disease. This research aims to study the effect of steeping rosella flower petals showed differences in pulse pressure, plasma MDA and SATs in the blood of rats fed 20% alcohol dose 4 grams/kg body weight/day as a trigger of reactive oxygen species. Thirty male wistar rats at least 150 grams of body weight divided into five groups, each group of six rats. Group A was given boiled water, group B was given alcohol, groups C, D and E are given alcohol and rosella. Dose of 0.75 grams rosella rosella in 200 cc of the water brewing given to kelompom C, while group D rosella dose 1.5 g and E 3 gr. Giving rosella and alcohol for 70 days by way of the sonde. Rosella alcohol given at 7:00 and 11:00 hours. Pulse pressure, plasma MDA and plasma levels of SAT were measured before and after treatment. The results showed that pulse pressure, plasma MDA steeping rosella groups given 0.75 g, 1.5 grams and 3 grams of lower and higher SAT levels compared with groups given alcohol alone. Conclusion rats fed steeping rosella flower petals and alcohol pulse pressure, lower levels of plasma MDA and higher SAT levels compared with groups that were given alcohol alone.

Co-Authors -, Prasetyastuti A.A. Ketut Agung Cahyawan W Achmad Djuneadi Budi Iman Santoso Budi Siswanto Dwi Aris Agung Dwi Aris Agung Nugrahaningsih Dwi Cahyani Ratna Sari Ginus Partadiredja Iman, Santoso Budi Januar Rizqi Januar Rizqi Marsetyawan HNE Soesatyo Nur Arfian Nuring Pangastuti, Nuring Ova Emilia Rahmaya Nova Handayani Sabirin, Rahmaningsih Mara Saidah Rauf Setiorini, Anggi Setyo Purwono Siti Kaidah Soedjono, Sri Kadarsih Sofro, Zaenal Muttaqien Sri Widodo

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