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All Journal Jurnal Kedokteran dan Kesehatan : Publikasi Ilmiah Fakultas Kedokteran Universitas Sriwijaya Majalah Patologi Indonesia
Nursanti Apriyani
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience Public Health

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Korelasi Ekspresi p16 dengan Lesi Prakanker dan Karsinoma Sel Skuamosa Serviks Uteri Dina Ekawati; Wrednindyatsih Wrednindyatsih; Nursanti Apriyani
Majalah Patologi Indonesia Vol 28 No 1 (2019): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (369.904 KB)

Abstract

Latar belakangKanker serviks merupakan keganasan keempat terbanyak pada wanita di seluruh dunia, sedangkan diIndonesia merupakan kanker terbanyak kedua setelah kanker payudara. Patogenesis kanker serviks dikaitkandengan infeksi human papillomavirus (HPV). Kanker serviks berkembang secara bertahap, diawali lesiprakanker yang memerlukan waktu 10-15 tahun sampai menjadi karsinoma invasif. Untuk membantumenegakkan diagnosis suatu lesi prakanker (LSIL dan HSIL) serta KSS pada hasil biopsi yang meragukandapat digunakan penanda p16. Pemeriksaan imunohistokimia p16 memiliki sensitifitas dan spesifisitas yangtinggi terhadap diagnosis lesi HPV resiko tinggi dan akan menunjukkan ekspresi berlebihan p16. Tujuanpenelitian ini untuk menganalisis korelasi ekspresi p16 pada lesi prakanker dan KSS.Metode.Penelitian ini bersifat observational analitik dengan pendekatan cross-sectional. Populasi penelitian adalah blokparafin sediaan LSIL, HSIL dan KSS yang tersimpan di Departemen Patologi Anatomik RSUP Dr. Moh. HoesinPalembang periode 1 Mei 2014 sampai dengan 31 April 2017. Dari masing-masing kasus diambil 12 sampel.Slaid dari blok parafin yang memenuhi kriteria dilakukan pulasan imunohistokimia menggunakan antibodi p16.Perbedaan ekspresi p16 pada LSIL, HSIL dan KSS dianalisis menggunakan uji chi-square.Hasil.Usia terbanyak pasien LSIL adalah 30-40 tahun dan KSS adalah 51-60 tahun. Analisis statistik ekspresi p16antara LSIL, HSIL dan KSS menunjukkan perbedaan bermakna (p<0,05). Seluruh kasus KSS dan HSILmenujukkan ekspresi p16 sedang sampai kuat, sedangkan kasus LSIL menunjukkan ekspresi p16 yang lemah.Kesimpulan.Ekspresi p16 meningkat pada lesi HSIL dan KSS. Ekspresi p16 antara lesi prakanker (LSIL dan HSIL) dan KSSmenunjukkan korelasi bermakna.
Hubungan Kepadatan Tumor Associated Macrophages CD-68 dan Karakteristik Klinikopatologi pada Karsinoma Payudara Invasif Miko Kresna Handayani; Heni Maulani; Nursanti Apriyani
Majalah Patologi Indonesia Vol 29 No 2 (2020): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (317.25 KB) | DOI: 10.55816/mpi.v29i2.417

Abstract

BackgroundBreast carcinoma is the most common malignancy among women worldwide. Many factors can influence prognosis of the disease.Tumor microenvironment (TME) is enriched in highly active immune cells. Herein, tumor associated macrophages (TAM) are themost prevalent immune cells. TAM can enhance tumor progression by promoting angiogenesis, invasion and metastasis. Somestudies demonstrate that high density of macrophages infiltration associated with poor prognosis. The aim of the study is todetermine the association between TAM density and clinicopathological characteristics of breast invasive carcinoma.MethodsDescriptive study with case series design on January 1, 2015-October 31, 2017 was performed at Department of AnatomicalPathology Faculty of Medicine University of Sriwijaya/dr. Moh. Hoesin General Hospital Palembang on 48 samples invasivecarcinoma mammae subtype unspecific, and have already staining with immunohistochemistry staining ER, PR, HER-2 and Ki-67,surrogate markers. Then immunohistochemistry staining using CD-68 antibody was conduced. The association between TAMdensity and clinicopathological characteristics were analyzed by using Spearman’s Rho test.ResultsThe majority of the patient are older than 40 years of age (77.1%), with positive lymphovascular invasion (79.2%), and at the gradeIII (62.5%). Bivariate analysis between TAM CD-68+density in stromal tumor and subtype luminal A showed negative correlationmoderate significantly (r= -0.398; p=0.005) while between TAM CD-68+density in stromal tumor and subtype triple negative showedpositive correlation moderate significantly (r=0.335; p=0.020).ConclusionTAM CD-68+density in stromal tumor was significantly correlated with luminal A and triple negative subtype.
Hubungan Tingkat Ekspresi Fibroblast Activation Protein (FAP) Terhadap Faktor Klinikopatologi Karsinoma Tiroid Papiler Herlina; Heni Maulani; Nursanti Apriyani
Majalah Patologi Indonesia Vol 30 No 3 (2021): MPI
Publisher : Perhimpunan Dokter Spesialis Patologi Indonesia (IAPI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (457.817 KB) | DOI: 10.55816/mpi.v30i3.478

Abstract

BackgroundPapillary thyroid carcinoma is the most common subtype among thyroid cancers. The interaction between cancer cells and tumormicroenvironment plays roles in cancer proliferation and invasiveness. One of important components of tumor microenvironmentthat could stimulate tumor proliferation and invasiveness is activated fibroblast, known as carcinoma associated fibroblasts (CAFs).The aim of this research is to analysed FAP expression is associated with clinicopathologic characteristics.MethodsThis retrospective descriptive observational study with serial cases design was conducted in 40 samples of the paraffin blocks oftissues registered in Department of Anantomical Pathology Faculty of Medicine University of Sriwijaya/Dr. Moh. Hoesin PalembangHospital from January 1st, 2017 to October 31st, 2019. All samples were immunostained with FAP antibody. The expressions of FAPwere evaluated in accordance with the results of the previous study. Statistical test was performed by using Chi-square andSpearman-rho statistical test. Statistical analysis was performed by using SPSS version 23.0.ResultsOur data indicated that patients who were ≥45 years old (21 cases; 52.5%), women (31 cases; 77.5%) suffered from this cancer themost. The stromal type found in ten classic, follicular, solid and columnar variance were pauci (25 cases; 62.6%), desmoplastic (8cases;20%), sclerosis (5 cases; 12.5%) and inflammatory (2 cases; 5%). The expression of FAP in tumor stroma has a significantcorrelation with histopathology subtypes (p=0.028) and stromal type (p=0.000).ConclusionFAP was expressed in tumor epithelial cells and fibroblast stromal tumour of papillary thyroid carcinoma. FAP expression in stromaltumor between histopathologic subtype and stromal type showed significant correlation
Ekspresi alpha methylacyl co-a racemase (amacr) pada adenokarsinoma prostat dan high grade prostatic intraepithelial neoplasia (hgpin) Riefrini Nurlaili; Wresnindyatsih Wresnindyatsih; Nursanti Apriyani; M.Irsan Saleh
JURNAL KEDOKTERAN DAN KESEHATAN Vol 4, No 2 (2017)
Publisher : Fakultas Kedokteran Universitas Sriwijaya

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Abstract

Karsinomaprostat di Indonesia berada diurutan terbanyak kesepuluh dan urutan pertama terbanyak pada laki-laki. Adenokarsinomaprostat(AP) kadang sulit didiagnosis karena adanya gambaran morfologi menyerupai lesiganas, seperti high grade prostatic intra epithelial neoplasia (HGPIN).AMACR merupakan suatu penanda baru yang dapat membedakan AP dan HGPIN dengan sensitivitas dan spesifisitas tinggi. Penelitian ini bertujuan mengetahui ekspresi AMACR pada kedua lesi tersebut. Penelitian dilakukan disentradiagnostik laboratorium Patologi Anatomi Fakultas Kedokteran Universitas Sriwijaya/RSUP Dr. Moehammad Hoesin Palembang, secara retrospektif observasional dengan desain potong lintang pada sampel blokparafin dengan diagnosis APdanlesi yang mengandung HGPIN. Sampel berjumlah 50, diambil dari arsip rekam medic periode 1 Januari 2012- 31 Mei 2015 secara consecutive  sampling, dan dilakukan pulasan AMACR. Hasil dianalisis dengan  SPSS 17. Didapatkan lesiprostat terjadi pada usia lebih dari 60 tahun (84%), dengan AP86%, dan HGPIN 83%, proporsi AP berdiferensiasi buruk 34 kasus (94,4%), tidak dijumpai perbedaan bermakna derajat diferensiasi dengan ekspresi AMACR (p-value 1,000), terdapat perbedaan yang bermakna antara ekspresi AMACR pada APdan HGPIN (p=0,001).
Co-Authors Dina Ekawati Fadillah Heni Maulani Herlina M.Irsan Saleh Miko Kresna Handayani Riefrini Nurlaili Wrednindyatsih Wrednindyatsih Wresnindyatsih Wresnindyatsih