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All Journal E-Jurnal Medika Udayana Jurnal Epidemiologi Kesehatan Komunitas
Irawan, Angeline Aprilia
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Health Professions Medicine & Pharmacology Public Health

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PENGARUH TESTOSTERONE REPLACEMENT THERAPY TERHADAP PROFIL LIPID DAN LEMAK PADA TUBUH Irawan, Angeline Aprilia; Kurniawan, Yukhi; Satriyasa, Bagus Komang; Widianti, I Gusti Ayu
E-Jurnal Medika Udayana Vol 11 No 4 (2022): E-Jurnal Medika Udayana
Publisher : Universitas Udayana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24843/MU.2022.V11.i04.P12

Abstract

translator Afrikaans Albanian - shqipe Arabic - ??????????? Armenian - ??????? Azerbaijani - az?rbaycanca Basque - euskara Belarusian - ?????????? Bengali - ????? Bulgarian - ????????? Catalan - català Chinese - ???????? Chinese - ?? (????) Croatian - hrvatski Czech - ?eština Danish - dansk Dutch - Nederlands English Esperanto - esperanto Estonian - eesti Filipino Finnish - suomi French - français Galician - galego Georgian - ??????? German - Deutsch Greek - ???????? Gujarati - ??????? Haitian Creole - kreyòl ayisyen Hebrew - ????????? Hindi - ?????? Hungarian - magyar Icelandic - íslenska Indonesian - Bahasa Indonesia Irish - Gaeilge Italian - italiano Japanese - ??? Kannada - ????? Korean - ??? Latin - Lingua Latina Latvian - latviešu Lithuanian - lietuvi? Macedonian - ?????????? Malay - Bahasa Melayu Maltese - Malti Norwegian - norsk Persian - ????????? Polish - polski Portuguese - português Romanian - român? Russian - ??????? Serbian - ?????? Slovak - sloven?ina Slovenian - slovenš?ina Spanish - español Swahili - Kiswahili Swedish - svenska Tamil - ????? Telugu - ?????? Thai - ??? Turkish - Türkçe Ukrainian - ?????????? Urdu - ???????? Vietnamese - Ti?ng Vi?t Welsh - Cymraeg Yiddish - ????? Double-click Select to translate After turning 40 years old, testosterone hormone in men will decrease, but some data regarding the effect of Testosterone Replacement Therapy (TRT) on cardiovascular safety is still controversial. The aim of this systematic review is to investigate the effect of TRT on lipid profile and body fat in men with Late-Onset Hypogonadism (LOH) which affects the incidence of cardiovascular disease. The literature search was performed on the database, such as PubMed and Wiley Online Library and also additional manual searches were performed on the reference list of related studies. The identified articles were selected according to the eligibility criteria. A total of four articles were used in this systematic review and the quality of the study was assessed using the Jadad score. From the four studies that is used, four study discussed the effect of TRT on lipid profiles and two studies discussed the effect of TRT on body fat. On the administration of testosterone gel 50mg/day, all lipid profiles improved after nine months of intervention. However, with IM testosterone after one year, the improvement was only partial. All studies discussing the effect of TRT on body fat showed uniform results, namely a decrease in fat percentage. The results obtained by the studies included in this systematic review suggest that TRT can improve lipid profiles and also decrease body fat in men with LOH.
Effectivity of Earthworm (Lumbricus rubellus) Extract as Antidiarrhea Caused by Enteropathogenic Escherichia Coli Irawan, Angeline Aprilia; Putri, Gita Almira; Dhumaranang, Hyangayu Dedari; Indrayani, Agung Wiwiek
Jurnal Epidemiologi Kesehatan Komunitas Vol 9, No 2 : Agustus 2024
Publisher : Master of Epidemiology, Faculty of Public Health, Diponegoro University, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jekk.v9i2.9141

Abstract

Background: Diarrhea still becomes a health problem in Indonesia with a high mortality rate among children under five years old. Antibiotics are used in the management of diarrhea caused by Enteropathogenic Escherichia coli, but it can change the intestinal microbiota in children and can cause resistance. Therefore, raw material is needed as an antibacterial.Methods: The sources of the narrative review come from Google Scholar, PubMed, and ResearchGate with keywords such as earthworm, Lumbricus rubellus, earthworm extract, antidiarrhea, and Escherichia coliResult: Earthworms (Lumbricus rubellus) have some active compounds that are useful for fibrinolytic, thrombolytic, antithrombotic, anti-inflammatory, antioxidant, and broad-spectrum antimicrobial properties. The antimicrobial activity of earthworms is due to the presence of Lumbricin-1 content where its activity against Escherichia coli has been proven by various studies.Conclusion : Earthworm (Lumbricus rubellus) extract can inhibit the growth of Escherichia coli bacteria so it has the potential to become an antidiarrheaKeywords: antidiarrheal; earthworm; Lumbricus rubellus; Lumbricin-1; Enteropathogenic Escherichia coli  
Co-Authors Agung Wiwiek Indrayani Bagus Komang Satriyasa Dhumaranang, Hyangayu Dedari Kurniawan, Yukhi Putri, Gita Almira Widianti, I Gusti Ayu