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All Journal Indonesia Medicus Veterinus Jurnal Kesehatan Andalas
Rosdianto, Aziis Mardanarian
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Health Professions Medicine & Pharmacology Veterinary

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Kajian Pustaka: Pemanfaatan Tikus Sebagai Hewan Model Trauma Tumpul (Kontusio) Wuri, Rahmitiana; Rosdianto, Aziis Mardanarian; Goenawan, Hanna
Indonesia Medicus Veterinus Vol 10 (2) 2021
Publisher : Faculty of Veterinary Medicine, Udayana University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.19087/imv.2021.10.2.338

Abstract

Seringkali kejadian memar pada manusia maupun hewan menjadi bahan kajian yang menarik untuk diteliti sehingga banyak peneliti yang mencari dan melakukan formulasi penanganan/pengobatan untuk kesembuhan memar. Ragam efek dari pengaplikasian suatu zat/obat baru pada manusia dapat diketahui dengan mempelajari efek kumulatif dari dosis pada tahap praklinik. Informasi tersebut diperoleh dari melakukan eksperimen laboratorium secara in vivo dengan menggunakan hewan coba sebagai model yang dirancang pada serangkaian uji praklinik, seperti menggunakan tikus (Rattus norvegicus). Sejauh ini pengembangan mengenai pemanfaatan tikus sebagai hewan model memar masih sangat potensial untuk dipelajari lebih lanjut. Kajian literatur ini membahas mengenai penggunaan hewan sebagai model memar, tren tikus sebagai hewan model memar, prinsip etik dan animal welfare hewan model, penjelasan dan klasifikasi memar, metode pembuatan memar, dan aspek pengembangan hewan model masa depan sebagai subjek penelitian.
Efek Suplementasi Selenium terhadap Marker Darah Pasca Cedera Kontusio Daba, Mariel; Goenawan, Hanna; Tarawan, Vita Murniati; Rosdianto, Aziis Mardanarian; Lesmana, Ronny
Jurnal Kesehatan Andalas Vol. 10 No. 2 (2021): Online July 2021
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v10i2.1787

Abstract

Selenium is a trace element that has antioxidant properties and is a component of selenoproteins. In certain circumstances, such as injury, selenium supplementation is required to regulate the inflammatory response. Contusion injury increases the inflammatory response to a muscle or tissue that begins with vasodilation, increases blood flow, increases vascular permeability, and leads to edema formation at the site of injury. Objectives: To determine the effect of selenium supplementation on changes in blood markers in rats treated with contusion injury. Methods: Experimental design, using experimental male rats (Rattus norwegius), eight weeks old, weighing 200-220 grams, divided into three groups, namely: The Control group, the contusion group, the contusion + Selenium group. Selenium supplementation was given orally on days 1-3 after injury at a dose of 0.0153 mg into 2% PGA. Examination of markers such as White Blood cells (WBC), lymphocytes, monocytes, and neutrophils was carried out on day three after treatment. Results: This study found that the administration of post-muscular selenium supplementation based on examination of blood markers such as WBC, Lymphocytes, Monocytes was higher in the contusion group and lower in the selenium group. Neutrophils were higher in the contusion and selenium groups. This was not significantly different from the control group. The result of blood marker examination tended to change, but it was not statistically significant. Conclusion: Selenium supplementation in post-contusive injury mice did not provide significant changes in blood markers such as WBC, lymphocytes, monocytes, and neutrophils.Keywords:  antioxidant, blood marker, contusion, selenium
Co-Authors Daba, Mariel Hanna Goenawan Ronny Lesmana Vita Murniati Tarawan Wuri, Rahmitiana