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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Journal of Biomedicine and Translational Research Jurnal Respirasi (JR) Medica Hospitalia Jurnal Ners JOURNAL LA MEDIHEALTICO Indonesian Health Journal Jurnal Indonesia Sosial Teknologi
Kusumawardhani, Erna
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Economics, Econometrics & Finance Environmental Science Health Professions Law, Crime, Criminology & Criminal Justice Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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Clinical and Laboratory Features of COVID-19 in Ulin Referral Hospital of South Kalimantan: Predictors of Clinical Outcome Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Nurrasyidah, Ira; Kusumawardhani, Erna; Suhartono, Eko; Arganita, Fidya Rahmadhany
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.06

Abstract

Corona Virus Disease (COVID-19) is becoming a global pandemic. Indonesia, especially South Kalimantan had recorded increasing cases with a high fatality rate of 3.7%. Information about factors related to outcomes based on clinical and laboratory features in Indonesia is still limited. Identification of the risk is crucial to determine optimal management and reducing mortality. This retrospective study enrolled 455 adults COVID-19 patients, and data were extracted from medical records of Ulin General Hospital Banjarmasin. The latter is COVID-19 referral hospital in South Kalimantan between March-November 2020. Demographic data, comorbidities, and laboratory were all collected. Data were compared between survivors and non-survivors. Fisher’s exact test and chi-square were used to compare categorical variables. The Mann_Whitney U test was used to compare continuous variables. Analysis was continued by multivariate logistic regression then receiver operating characteristic (ROC) curve to determine cut-off value. The multivariate analysis showed that number of comorbidities [odds ratio (OR) 1,339 (95% confidence interval (CI): 1,064-1,685, P = 0,013) was a significant risk factor to the outcome. In laboratory, lactate dehydrogenase (LDH) [OR: 1.001, 95% CI: 1,000-1.002, P = 0.001], Ferritin (OR 1.000, CI: 1,000-1.001, P = 0.013), APTT (OR: 1.045, CI: 1.010-1.082, P = 0.012), and D-dimer (OR: 1.188, CI: 1.064 - 1.327, P = 0.002) were significant predictor factors but only LDH, ferritin, and D- dimer were obtained good AUC 0.731, 0.715, and 0.705, respectively. The cut of the value of LDH was 656.5 U/L, ferritin was 672.18 ng/ml, and D-dimer was 2.28 mg/L. Sensitivity and specificity were 66.7% and 68,0% for LDH, 83,2% and 56,3% for ferritin, and 62,8 and 70,8% for D-dimer. From this research, we revealed that the number of comorbidities was a risk factor for death. Elevated LDH, ferritin, and D-dimer could be good predictive factors for poor outcomes, thereby considering the accelerating management of COVID-19 patients.
High Pre-treatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) Shows Lower Progressive-free Survival and Overall Survival in Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Kusumawardhani, Erna; Haryati, Haryati; Arganita, Fidya Rahmadhany
Journal of Biomedicine and Translational Research Vol 9, No 3 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i3.19403

Abstract

Background: The role of Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as an easy and inexpensive prognostic examination modality has different results. While the combination of the two has never been done.Objective: This study investigated the association between NLR/PLR and outcomes in advanced lung adenocarcinoma Epidermal Growth Factor Receptor (EGFR) mutation-positive with Tyrosine Kinase Inhibitor (TKI) treatment.Methods: This retrospective study enrolled 40 medical records of lung adenocarcinoma patients treated with TKI in Ulin General Hospital from 2017-2019, with follow-up until April 1, 2021. A receiver operating curve (ROC) was performed to determine the optimal cut-off and parallel tests of NLR/PLR combination. The Kaplan-Meier was used to evaluate the impact on progressive-free survival (PFS) and overall survival (OS).Results: The optimal cut-off was 6.25 for NLR and 451.5 for PLR with sensitivity and specificity of PFS (31.6%, 100%, and 18.4%, 100%) and OS (32.4%, 100% and 8.9%, 100%) (AUC 0.362, 0.329 and 0.482, 0.477) respectively. Patients in NLR <6.25 and PLR <451.5 groups presented longer PFS (10 months, 95% CI:7.783 -12.217, vs. 8 months, 2.908-13.092, p=0.821; 10 months, 7.508 – 12.492 vs. 9 months, 6.434-11.566, p=0.513) and OS (20 months, 14.017-25.983 vs.16 months, 11.474-20.526, p=0.378; 20 months, 14.629-25.371 vs. 14 months, 3.735-24.265, p=0.382) but not significantly correlated.Conclusion: High pre-treatment NLR and PLR showed shorter PFS and OS, although they did not appear as a prognostic marker for PFS and OS of EGFR-mutant lung adenocarcinoma treated with TKI.
The Influence of inflammatory factors (IL-6, CRP, NLPR, D-Dimer, LDH) on the PaO2/FiO2 ratio, in patients with severe and critical degrees of COVID-19 Harnoto, Yulia Octaviany; Assagaf, Ali; Pratiwi, Dewi Indah Noviana; Isa, Mohamad; Nurrasyidah, Ira; Kusumawardhani, Erna
Medica Hospitalia : Journal of Clinical Medicine Vol. 10 No. 3 (2023): Med Hosp
Publisher : RSUP Dr. Kariadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36408/mhjcm.v10i3.1014

Abstract

BACKGROUND: Several types of inflammatory biomarkers that are important in severe and critical Covid-19 infections include: levels of IL-6, C-reactive protein (CRP), lactate dehydrogenase (LDH), D-Dimer and neutrophil-lymphocyte platelet ratio (NLRP), which are independent variables. Meanwhile, the severity of Covid-19 infection can be determined by measuring the PaO2 /FiO2 ratio. However, the relationship between the PaO2/FiO2 ratio as the dependent variable is not yet known. AIMS: To analyze the relationship between PaO2/FiO2 ratio and inflammatory biomarkers in COVID-19 patients METHOD: An analytic observational study with a retrospective, cross-sectional approach. The research sample consisted of PCR-confirmed severe and critical COVID-19 patients who were treated in the isolation room of the Ulin Hospital in Banjarmasin from August–December 2021, who met the inclusion and exclusion criteria. Data analysis used the Spearman test to see the relationship between the PaO2/FiO2 ratio and various inflammatory markers. RESULT: 52 severe and critical patients were observed according to the research flow. The number of male and female subjects (32/20) was found. The mean age was 55.38 years. The correlation test found that: there was no significant relationship between the PaO2/FiO2 ratio and IL-6 (p = 0.964), but there was a negative correlation between the PaO2/FiO2 ratio and: a).CRP (p = 0.038), b).LDH ( p<0.001), c).NLPR (p = 0.013), and d). D-dimer (p<0.001). The inflammatory biomarkers NLPR, LDH, and D-dimer are important independent variables for the severity of COVID-19, namely the PaO2/FiO2 ratio. CONCLUSION: There are a significant correlation between the PaO2/FiO2 ratio to measure the severity of Covid-19 and several inflammatory biomarkers CRP, LDH, NLPR and D-dimer  
The Effect Of Nigella Sativa Administration In Reducing Oxidative Damage In Covid-19 Patients: A Clinical And In Silico Study Diany, Holly; Nurrasyidah, Ira; Haryati, Haryati; Isa, Mohamad; Kusumawardhani, Erna
Indonesian Health Journal Vol. 3 No. 3 (2024): Indonesian Health Journal
Publisher : Riviera Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.58344/ihj.v3i3.552

Abstract

The COVID-19 pandemic has posed significant challenges to public health, particularly about the oxidative damage caused by infection. Nigella sativa, known for its antioxidant properties, has been extensively studied as a potential therapeutic agent to reduce oxidative damage. This study aims to evaluate the effects of Nigella sativa administration in reducing oxidative damage in COVID-19 patients through a clinical and in silico approach. The research methods include a clinical trial on COVID-19 patients supplemented with Nigella sativa and in silico molecular analysis to identify the interaction mechanisms between the active components of Nigella sativa and SARS-CoV-2 proteins. The results showed that Nigella sativa significantly reduced oxidative stress biomarkers in patients, and in silico results revealed the potential of its active components to inhibit critical enzymes of the SARS-CoV-2 virus. Based on these findings, it is concluded that Nigella sativa has potential as an adjunct therapy in reducing oxidative damage in COVID-19 patients. Further research is required to confirm these results through broader, more in-depth clinical trials.
The Effect of Platinum-Based Chemotherapy in Advanced Non-Small Cell Carcinoma Lung Cancer (NSCLC) on Cardiovascular Events in Ulin Hospital Banjarmasin Ramadhaniati, Widya; Kusumawardhani, Erna; Haryati, Haryati; Putro, Dwi Laksono Adi; Isa, Moh.; Assagaf , Ali
Jurnal Ners Vol. 9 No. 2 (2025): APRIL 2025
Publisher : Universitas Pahlawan Tuanku Tambusai

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31004/jn.v9i2.39470

Abstract

Chemotherapy for lung cancer can provide many benefits, but it also has side effects that cause side effects of treatment, one of which is in the field of cardiology. This study was conducted to assess the cardiovascular side effects of platinum-based chemotherapy in advanced stage non-small cell lung cancer. This research method uses a retrospective cohort design. Samples diagnosed with advanced stage KPKBSK who underwent first-line platinum-based chemotherapy underwent electrocardiography and echocardiography assessments at the beginning and after the fourth cycle or when cardiovascular disorders occurred to assess the incidence of atrial fibrillation, PAC, ST-T segment changes, prolonged QT, decreased EF and E/A ratio at Ulin Banjarmasin Regional General Hospital in April 2022-April 2023. The results of this study indicate that chemotherapy for lung cancer with hypertension has an effect on decreasing ejection fraction (p-value <0.05, OR: 0.409). In the group of lung cancer with coronary heart disease receiving chemotherapy, the incidence of atrial fibrillation increased (p-value <0.05, OR: 20). Furthermore, cardiovascular events such as atrial fibrillation increased (p-value <0.05, OR: 6.800) and PAC (p-value <0.05, OR: 6.800) in the squamous cell carcinoma and adenocarcinoma lung cancer groups (p-value <0.05, OR: 0.409). There was no decrease in the E/A ratio and prolonged QT with chemotherapy. The conclusion of this study is that there is no effect of platinum-based chemotherapy on cardiovascular events in advanced lung cancer, but administration to groups with comorbid hypertension and coronary heart disease has an effect on increasing cardiovascular events in lung cancer patients at Ulin Banjarmasin Hospital.
Effect of Omega-3 Addition on Sputum Conversion, Body Mass Index, Interleukin-6, and Lymphocyte Monocyte Ratio in the Treatment of Pulmonary Tuberculosis Ferryansyah, Ferryansyah; Mohamad Isa; Juhairina; Haryati; Assagaf, Ali; Kusumawardhani, Erna
Jurnal Indonesia Sosial Teknologi Vol. 6 No. 3 (2025): Jurnal Indonesia Sosial Teknologi
Publisher : Publikasi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59141/jist.v6i3.7050

Abstract

This research aims to investigate the impact of omega-3 supplementation on sputum conversion, body mass index (BMI), interleukin-6 (IL-6) levels, and lymphocyte-monocyte ratio (LMR) in patients with pulmonary tuberculosis (TB). Tuberculosis is a significant health problem in Indonesia, with high incidence and mortality rates. Omega-3 fatty acids are known to have anti-inflammatory effects and may enhance the immune response, potentially supporting tuberculosis (TB) therapy. The research methods included bacteriological examination of the sputum, measurement of BMI, IL-6 levels, and MLR in patients who received additional Omega-3 compared to the control group. The results are expected to provide an overview of the effectiveness of Omega-3 as a supportive therapy in treating TB, as well as its contribution to improving patients' nutritional status and immune response. This research is expected to serve as a reference for developing more effective and affordable tuberculosis therapies.
The Effect of Suplementation Omega-3 on Sputum Conversion, Body Mass Index, Interleukin-6 and Monocyte Lymphocyte Ratio in the Treatment of Pulmonary Tuberculosis Ferryansyah, Ferryansyah; Isa, Mohamad; Juhairina, Juhairina; Haryati, Haryati; Assagaf, Ali; Kusumawardhani, Erna
Journal La Medihealtico Vol. 6 No. 3 (2025): Journal La Medihealtico
Publisher : Newinera Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37899/journallamedihealtico.v6i3.2041

Abstract

Tuberculosis (TB) is a disease caused by Mycobacteriun Tuberculosis. Its cases continue to increase both in Indonesia, and in the world. Efforts to increase the success rate of TB treatment and reduce the level of transmission need to continue to be developed, one of which is with additional therapy in its treatment. Omega-3 has anti-inflammatory and anti-bacterial potential, which is predicted to increase the success of TB treatment, as seen from sputum conversion, increased body mass index (BMI) and important inflammatory parameters in TB infection namely interleukin-6 (IL-6), monocyte lymphocyte ratio (MLR) values. This study was conducted to determine the effect of Omega-3 addition on sputum conversion, BMI, IL-6 levels and MLR values in pulmonary tuberculosis treatment. Experimental study with consecutive sampling in drug-sensitive pulmonary TB patients who were given additional Omega-3 dose of 1,200 mg (@600mg/capsule), compared with the control group. Each sample was monitored for sputum conversion, BMI, IL-6 levels and MLR values at week 0 (m0), week 4 (m4) and week 8 (m8). In this study, there was a significant effect of adding Omega-3 on reducing IL-6 levels (p= 0.013), reducing MLR values (p= 0.005) and increasing BMI (p= 0.047) but no significant effect on sputum conversion (p= 1,000). The addition of Omega-3 had a significant effect on reducing IL-6 levels, reducing MLR values and increasing BMI, but did not have a significant effect on sputum conversion in pulmonary TB treatment.
Differentiation of Malignant Pleural Effusions from Lung Squamous Cell Carcinoma and Adenocarcinoma through FTIR Spectroscopy: A Prognostic Approach Madargerong, Vincentius Adrian; Suhartono, Eko; Oktaviyanti, Ika Kustiyah; Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Kusumawardhani, Erna; Nurrasyidah, Ira; Syafa’ah, Irmi
Jurnal Respirasi Vol. 11 No. 2 (2025): May 2025
Publisher : Faculty of Medicine Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/jr.v11-I.2.2025.114-122

Abstract

Introduction: Malignant pleural effusion (MPE) is common in cancer patients and is often caused by neoplastic involvement of the pleural surface. This study aimed to determine the utility of Fourier transform infrared spectroscopy (FTIR) spectral analysis and anatomical pathological differentiation in MPE, squamous cell carcinoma (SCC), and lung adenocarcinoma as prognostic predictors. Methods: This study used a cross-sectional design at Ulin General Hospital, Banjarmasin, involving advanced lung cancer patients with MPE. A non-probability sampling technique was used to recruit 30 patients. Fourier transform infrared spectroscopy was analyzed to evaluate anatomical pathology differentiation. Results: Differences were observed in the FTIR spectral ratios A1080/A1243 and A1080/A1170 between SCC and adenocarcinoma, with p-values of 0.026 and 0.022, respectively. Significant differences were also found in the A2959/A1545 ratio between well-differentiated and poorly differentiated adenocarcinomas, with a p-value of 0.023. The receiver-operating characteristic curve (ROC) indicated good predictive value for poorly differentiated adenocarcinoma at a cut-off value of 0.944, with a sensitivity of 50% and specificity of 100%. However, no significant correlation was found between FTIR absorbance and anatomical pathology differentiation in MPE due to SCC and lung adenocarcinoma. Conclusion: The FTIR spectral ratios A1080/A1243 and A1080/A1170 differentiate SCC from adenocarcinoma. Fourier transform infrared spectroscopy may be an adjunct to cytology, offering a more rapid and cost-effective method for differentiating MPE.
Co-Authors Ali Assagaf Arganita, Fidya Rahmadhany Assagaf , Ali Dewi Indah Noviana Pratiwi, Dewi Indah Noviana Diany, Holly Eko Suhartono Ferryansyah, Ferryansyah Harnoto, Yulia Octaviany Haryati Haryati Haryati Ika Kustiyah Oktaviyanti Ira Nurrasyidah Isa, Moh. Isa, Mohamad Juhairina Juhairina, Juhairina Madargerong, Vincentius Adrian Mohamad Isa Putro, Dwi Laksono Adi Ramadhaniati, Widya Syafa’ah, Irmi