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All Journal Journal of Tropical Life Science : International Journal of Theoretical, Experimental, and Applied Life Sciences Majalah Kedokteran Bandung Journal of Biomedicine and Translational Research Berkala Kedokteran Jurnal Profesi Medika: Jurnal Kedokteran dan Kesehatan Respiratory Science Indonesian Journal of Cancer
Arganita, Fidya Rahmadhany
Department Of Pulmonology And Respiratory Medicine, Faculty Of Medicine, Lambung Mangkurat University/Ulin Hospital, Banjarmasin, South Kalimantan, Indonesia
Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Environmental Science Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Clinical and Laboratory Features of COVID-19 in Ulin Referral Hospital of South Kalimantan: Predictors of Clinical Outcome Haryati, Haryati; Isa, Mohamad; Assagaf, Ali; Nurrasyidah, Ira; Kusumawardhani, Erna; Suhartono, Eko; Arganita, Fidya Rahmadhany
Journal of Tropical Life Science Vol 11, No 3 (2021)
Publisher : Journal of Tropical Life Science

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.11594/jtls.11.03.06

Abstract

Corona Virus Disease (COVID-19) is becoming a global pandemic. Indonesia, especially South Kalimantan had recorded increasing cases with a high fatality rate of 3.7%. Information about factors related to outcomes based on clinical and laboratory features in Indonesia is still limited. Identification of the risk is crucial to determine optimal management and reducing mortality. This retrospective study enrolled 455 adults COVID-19 patients, and data were extracted from medical records of Ulin General Hospital Banjarmasin. The latter is COVID-19 referral hospital in South Kalimantan between March-November 2020. Demographic data, comorbidities, and laboratory were all collected. Data were compared between survivors and non-survivors. Fisher’s exact test and chi-square were used to compare categorical variables. The Mann_Whitney U test was used to compare continuous variables. Analysis was continued by multivariate logistic regression then receiver operating characteristic (ROC) curve to determine cut-off value. The multivariate analysis showed that number of comorbidities [odds ratio (OR) 1,339 (95% confidence interval (CI): 1,064-1,685, P = 0,013) was a significant risk factor to the outcome. In laboratory, lactate dehydrogenase (LDH) [OR: 1.001, 95% CI: 1,000-1.002, P = 0.001], Ferritin (OR 1.000, CI: 1,000-1.001, P = 0.013), APTT (OR: 1.045, CI: 1.010-1.082, P = 0.012), and D-dimer (OR: 1.188, CI: 1.064 - 1.327, P = 0.002) were significant predictor factors but only LDH, ferritin, and D- dimer were obtained good AUC 0.731, 0.715, and 0.705, respectively. The cut of the value of LDH was 656.5 U/L, ferritin was 672.18 ng/ml, and D-dimer was 2.28 mg/L. Sensitivity and specificity were 66.7% and 68,0% for LDH, 83,2% and 56,3% for ferritin, and 62,8 and 70,8% for D-dimer. From this research, we revealed that the number of comorbidities was a risk factor for death. Elevated LDH, ferritin, and D-dimer could be good predictive factors for poor outcomes, thereby considering the accelerating management of COVID-19 patients.
Tocilizumab In Severe To Critical Confirmed COVID-19: A Case Series At Ulin Referral Hospital Of South Kalimantan Haryati Haryati; Fidya Rahmadhany Arganita; Widya Ramadhaniati
Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan Vol 15, No 1 (2021): Jurnal Profesi Medika : Jurnal Kedokteran dan Kesehatan
Publisher : Fakultas Kedokteran UPN Veteran Jakarta Kerja Sama KNPT

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33533/jpm.v15i1.2862

Abstract

Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) is a new type of coronavirus that causes pneumonia. The clinical severity of COVID-19 is related to the presence of a “cytokine storm” that causes overproduction of inflammatory mediators such as interleukin (IL)-6. Tocilizumab (TCZ) as an IL-6 inhibitor is subject of major studies as a potential therapeutic agent. This study reported 20 cases of COVID-19 patients being treated with the IL-6 inhibitor TCZ beside standard therapy. Patients were followed up on clinical, laboratory and chest x-rays before and after the administration of therapy which were report descriptively. The oxygen saturation of patients who survived shows rapid improvements. The laboratory results showed that CRP decreased after administration TCZ immediately. Meanwhile, other markers improve slowly, such as leucocytes, Neutrophyl Lymphocyte Ratio (NLR), Absolute Lymphocyte Count (ALC) and Lactate Dehydrogenase (LDH) but ferritin was tended to fluctuate. In chest X-ray’s, infiltrate bilateral on admission began to diminished until almost disappeared on the 14th day after TCZ. From 20 patients, 80% of patients survived with improvement in clinical, laboratory and chest X-rays, while the rest death with a good response on first therapy but fluctuated and worsened before death. Tocilizumab can be considered to provide clinical improvements in severe and critical COVID-19 patients.
Survival of Lung Adenocarcinoma Patients with Tyrosine Kinase Inhibitor Therapy Based on EGFR Mutation Status in Tumor and Plasma Samples Haryati, Haryati; Arganita, Fidya Rahmadhany; Oktaviyanti, Ika Kustiyah
Indonesian Journal of Cancer Vol 17, No 4 (2023): December
Publisher : http://dharmais.co.id/

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33371/ijoc.v17i4.995

Abstract

Background:The prognosis for epidermal growth factor receptor (EGFR)-mutated non-small cell lung cancer (NSCLC) is greatly improved when treated with tyrosine kinase inhibitor (TKI). In this context, EGFR mutation status should be determined at the diagnosis stage but circulating tumor DNA (ctDNA) has been increasingly used for molecular profiling. Therefore, this study aimed to establish the correlation between the presence of ctDNA before TKI therapy and subsequent clinical outcomes Methods: A total of 18 patients with NSCLC who received EGFR-TKI therapy were enrolled. EGFR mutations were simultaneously identified in tumor samples and plasma ctDNA, as well as information regarding overall survival (OS) and progression-free survival (PFS). Result: These case studies showed that 14 of 18 patients (77.8%) with concordance results detected EGFR-positive mutations on ctDNA examination and histopathology from plasma and tumor samples, respectively. The median PFS was similar at 7.5 months in both groups, while the median OS was shorter in patients with EGFR-detected in ctDNA (17 vs. 25.5 months) after TKI-targeted therapy. Conclusion: The identification of EGFR mutations in plasma ctDNA was a promising, effective, and minimally invasive alternative to tumor biopsy. The existence potentially reflected the disease burden and showed a poor prognosis.
High Pre-treatment Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) Shows Lower Progressive-free Survival and Overall Survival in Tyrosine Kinase Inhibitor-treated Lung Adenocarcinoma Kusumawardhani, Erna; Haryati, Haryati; Arganita, Fidya Rahmadhany
Journal of Biomedicine and Translational Research Vol 9, No 3 (2023): December 2023
Publisher : Faculty of Medicine, Universitas Diponegoro

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jbtr.v9i3.19403

Abstract

Background: The role of Neutrophil-to-Lymphocyte ratio (NLR) and Platelet-to-Lymphocyte ratio (PLR) as an easy and inexpensive prognostic examination modality has different results. While the combination of the two has never been done.Objective: This study investigated the association between NLR/PLR and outcomes in advanced lung adenocarcinoma Epidermal Growth Factor Receptor (EGFR) mutation-positive with Tyrosine Kinase Inhibitor (TKI) treatment.Methods: This retrospective study enrolled 40 medical records of lung adenocarcinoma patients treated with TKI in Ulin General Hospital from 2017-2019, with follow-up until April 1, 2021. A receiver operating curve (ROC) was performed to determine the optimal cut-off and parallel tests of NLR/PLR combination. The Kaplan-Meier was used to evaluate the impact on progressive-free survival (PFS) and overall survival (OS).Results: The optimal cut-off was 6.25 for NLR and 451.5 for PLR with sensitivity and specificity of PFS (31.6%, 100%, and 18.4%, 100%) and OS (32.4%, 100% and 8.9%, 100%) (AUC 0.362, 0.329 and 0.482, 0.477) respectively. Patients in NLR <6.25 and PLR <451.5 groups presented longer PFS (10 months, 95% CI:7.783 -12.217, vs. 8 months, 2.908-13.092, p=0.821; 10 months, 7.508 – 12.492 vs. 9 months, 6.434-11.566, p=0.513) and OS (20 months, 14.017-25.983 vs.16 months, 11.474-20.526, p=0.378; 20 months, 14.629-25.371 vs. 14 months, 3.735-24.265, p=0.382) but not significantly correlated.Conclusion: High pre-treatment NLR and PLR showed shorter PFS and OS, although they did not appear as a prognostic marker for PFS and OS of EGFR-mutant lung adenocarcinoma treated with TKI.
The Effectiveness of The Handwashing Program with Soap (CTPS) In Preventing E. Coli Contamination on Elementary School Student, West Martapura South Kalimantan Mutttaqien, Fauzan; Khatimah, Husnul; Fakhrurrazy, Fakhrurrazy; Arganita, Fidya Rahmadhany; Maulana, Irfan; Yuliana, Ida
Berkala Kedokteran Vol 20, No 1 (2024)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v20i1.18762

Abstract

Martapura river had been  discovered of indicators of microbial contamination of drinking water, namely total coliform and E coli which are harmful to health. CTPS program for elementary schools in West Martapura sub-district has been going  for  long time to prevent disease. Tihis study aimed to know the difference in the effectiveness of using Martapura river water for CTPS in elementary school children in Martapura Barat District to preventing E. Coli contamination. The research method used the true experiment method with a posttest only control group design research design. The research group named group (P1) CTPS using processed Martapura river water, group with hand washing soap (P2) CTPS using Martapura river water without being processed and group (K) CTPS with PDAM water . The research subjects were18  elementary student selected by simple random sampling technique.  The object study was the observation of the presence of Escherichia coli bacteria which were found from the hand swabs of elementary school children in West Martapura sub-district whose schools had treated water facilities and did not have treated water facilities. Also taking palm swabs for the research subjects, a quality test for PDAM water, Martapura river water and processed river water at the three elementary schools was carried out and examined at the Banjarbaru BBTKL-PPB Laboratory. The results showed that for CTPS water samples from PDAM water sources only counted 1 CFU E coli/100 ml, while CTPS water from the Martapura River and PAMSIMAS the number of E. coli colonies was > 200 CFU/100 ml. For all samples of palm swabs from the elementary school students, all results were negative for E. Coli CFU / cm2. The conclusion is that there is no difference in the effectiveness of using Martapura River water, both treated and untreated, in the CTPS program in reducing E.Coli numbers.
The Relationship of Serum Zinc Levels and Clinicopathological Characteristics in Individuals with Lung Cancer Haryati, Haryati; Eko Prasetyo, Nugroho; R. Simarmata, Eviriana; Parhusip, Mual Bobby Enrico; Arganita, Fidya Rahmadhany; Humaira, Adhwa
Respiratory Science Vol. 5 No. 1 (2024): Respiratory Science
Publisher : Indonesian Society of Respirology (ISR)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36497/respirsci.v5i1.143

Abstract

Background: Lung cancer is one of the main contributors to malignancy and leads to the patient's death. The immune system, genetics, and inflammation affect lung cancer progression. Zinc (Zn) is an essential mineral; a Zn deficiency increases the tumor suppressor's expression, damaging deoxyribonucleic acid (DNA) repair ability in tumor growth. The study focused on establishing a relationship between serum Zn levels and lung cancer patients' clinicopathologic characteristics. Method: Thirty-five patients diagnosed with lung cancer were part of the study. The study collected clinicopathological data and serum Zn levels at the initial diagnosis. Serum Zn insufficiency is characterized by a below 80 μg/dL serum Zn level. Results: The median Zn level in our study was 65 μg/dL (range=56.5-73 μg/dL). Serum Zn deficiency was observed in 91.4% of patients, particularly those who had a smoking history, advanced stage, or had hypoalbuminemia. The low-level group exhibited significantly lower albumin concentrations (3.06 g/dL vs. 3.66 g/dL; P=0.024) than the normal group. Conclusion: Most patients with lung cancer at initial diagnosis had a deficiency in Serum Zn, which was associated with hypoalbuminemia.
The Relationship between Drinking Water Sources and Nutritional Status of Elementary School Children on the Martapura Riverbank Khatimah, Husnul; Mutttaqien, Fauzan; Fakhrurrazy, Fakhrurrazy; Arganita, Fidya Rahmadhany; Maulana, Irfan; Yuliana, Ida
Berkala Kedokteran Vol 21, No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Lambung Mangkurat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20527/jbk.v21i1.22154

Abstract

Environment cleanliness has an indirect impact on nutritional status, particularly in the growth and development stages of children. In this study, school-age children living along the Martapura River's banks were asked to assess their nutritional health and the relationship between their drinking water sources. Study methodology employing a cross-sectional study design and analytical observational techniques. Research participants comprised 53 primary school students in grade 4 from SDN Keliling Benteng Ulu 2, SDN Keliling Benteng Tengah, and SDN Sungai Rangas Hambuku. Groups A (Martapura River water source group) and B (non-river water source group) comprised the seven groups of subjects: group 1 (very poor nutrition); group 2 (undernutrition); group 3 (normal nutrition); group 4 (obesity). Based on the data, it was discovered that 37 individuals (69.8%) had very poor nutritional status, and 39 individuals (73%), had the most commonly used gallons. The nutritional quality of primary school-aged children living along the Martapura Riverbanks did not significantly correlate with the sources of their drinking water, as indicated by the Fisher Exact test results, which revealed p = 0.146 (p > 0.05).
Prognostic Nutritional Index (PNI) at Admission Predicts In-Hospital Mortality of COVID-19-Infected Patients Haryati, Haryati; Isa, Mohamad; Rudiansyah, Mohammad; Juhairina, Juhairina; Nor, Muhamad; Arganita, Fidya Rahmadhany
Majalah Kedokteran Bandung Vol 57, No 2 (2025)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v57.3930

Abstract

Corona Virus Disease-2019 (COVID-19) was declared a pandemic in March 2020 and caused considerable deaths in all parts of the world. Mortality is influenced by the immune system status and increased vulnerability to infection, both related to nutritional status. The Prognostic Nutritional Index (PNI), calculated using lymphocyte count and albumin levels, may have the ability to more accurately characterize the nutritional and inflammatory conditions of COVID-19 patients. This retrospective study analyzed 967 COVID-19 patients at Ulin Hospital Banjarmasin, Indonesia, by examining demographic data, laboratory results, and PNI in relation to survival outcomes. The study revealed that factors such as age, sex, comorbidities (including hypertension, diabetes mellitus/DM, obesity, etc.), number of comorbidities, and disease severity correlated with mortality. Leucocyte count, lymphocyte count, albumin levels, and PNI all showed significant correlations with survival (p<0.001), suggesting that these factors may serve as useful prognostic indicators for COVID-19 patient’s survival. The PNI was associated with an increased risk of mortality, with a univariate odds ratio (OR) of 0.923. Receiver operating characteristic (ROC) analysis demonstrated that a PNI cut-off value of p<41.9 had a sensitivity of 44.9% and a specificity of 82.4%, with an area under the curve (AUC) of 0.666 (p<0.001). Hence, PNI at admission, which reflects patients' immune system and nutritional status upon hospital admission, can be used as a simple, cost-effective, and reliable predictor of mortality in COVID-19 patients.
Co-Authors Ali Assagaf Eko Prasetyo, Nugroho Eko Suhartono Fakhrurrazy Fakhrurrazy Haryati Haryati Haryati Haryati Humaira, Adhwa Ida Yuliana Ika Kustiyah Oktaviyanti Ira Nurrasyidah Irfan Maulana, Irfan Isa, Mohamad Juhairina, Juhairina Khatimah, Husnul Kusumawardhani, Erna Mohammad Rudiansyah Mutttaqien, Fauzan Nor, Muhamad Parhusip, Mual Bobby Enrico R. Simarmata, Eviriana Widya Ramadhaniati