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All Journal Jurnal Kedokteran Brawijaya The Indonesian Journal of General Medicine
Yusuf, Lydia
Unknown Affiliation
Dentistry Health Professions Medicine & Pharmacology Public Health Veterinary

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H2O2-Scavenging Activity and Hyaluronidase Inhibition Scutellarin and Apigenin in Basil Leaf Extract Yusuf, Lydia; Girsang, Ermi; Nasution, Ali Napiah; Elvira, Cut; Wibowo, Satrio Haryo Benowo; Widowati, Wahyu
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.1

Abstract

The potential utilization of flavonoid compounds, especially scutellarin, and apigenin, contained in basil (Ocimum basilicum L.) leaf extract to manage the aging effects on the skin, that occurs because of over-activated hyaluronidase enzyme and oxidative stress due to hydrogen peroxide (H2O2) radicals, is not well known. This study was conducted to assess the H2O2 scavenging activity and the inhibition of hyaluronidase from scutellarin and apigenin at various concentrations. The study was conducted by measuring H2O2 scavenging inhibition and hyaluronidase inhibition of scutellarin and apigenin in various concentrations using the spectrophotometry method. The various activity was tested using the One-Way ANOVA test followed by Tukey post hoc test. IC50 values were calculated based on linear regression equations of H2O2 scavenging inhibition and hyaluronidase inhibition. The analysis showed the highest H2O2 scavenging activity was found in scutellarin with IC50 158.76 μg/mL. Scutellarin has greater scavenging activity than apigenin. Hyaluronidase inhibition of scutellarin with IC50 35.25 µg/mL, while apigenin was 162.86 µg/mL. Scutellarin has higher hyaluronidase inhibition activity than apigenin. Antioxidant and antiaging effects of basil leaf extract caused by phytochemical compounds contained, especially scutellarin.
Understanding the Incidence of T2DM Following Gestational Diabetes Mellitus: A Comprehensive Systematic Review Yusuf, Lydia; Sylvia
The Indonesian Journal of General Medicine Vol. 1 No. 2 (2024): The Indonesian Journal of General Medicine
Publisher : International Medical Journal Corp. Ltd

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Abstract

Background: Gestational Diabetes Mellitus (GDM) is a common metabolic issue in pregnancy, marked by high plasma glucose levels first detected during pregnancy. Research shows that women with GDM have at least a seven-fold higher risk of developing T2DM compared to those with normal pregnancies.  This study aims to serve a comprehensive systematic review to analyze the incidence rate of T2DM after GDM in literatures of the last 10 years.  Methods: The review adhered to PRISMA 2020 standards and analyzed full-text English literature from 2014 to 2024. It excluded editorials, review papers from the same journal, and submissions lacking a DOI. Literature sources included PubMed, SagePub, SpringerLink, and Google Scholar. Result: A total of  500 articles were retrieved from online databases (PubMed, SagePub, SpringerLink and Google Scholar). After three rounds of screening, ten articles directly relevant to the systematic review were selected for full-text reading and analysis. Conclusion: Postpartum care and long-term monitoring for women with gestational diabetes mellitus (GDM) are essential due to the increased risk of type 2 diabetes mellitus (T2DM). Future research should target modifiable risk factors and enhance postpartum screening to mitigate associated health risks.
Co-Authors Elvira, Cut Girsang, Ermi Nasution, Ali Napiah Sylvia WAHYU WIDOWATI Wibowo, Satrio Haryo Benowo