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All Journal Jurnal Kedokteran Brawijaya Indonesian Journal of Jamu
Mardhiyyah, Kana
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Health Professions Medicine & Pharmacology

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Optimation of Combination of N-Hexane Solution and Ethyle Acetate on Secondary Metabolite Compounds Profile of Streptomyces hygroscopicus Ariel, Dio Giovanni; Winarsih, Sri; Putri, Fitria Febriliani; Erwan, Nabila Erina; Putri, Ajeng Maharani; Cahyono, Alfian Wika; Mardhiyyah, Kana; Fitri, Loeki Enggar; Nugraha, Rivo Yudhinata Brian
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.11

Abstract

Streptomyces hygroscopicus (S.hygroscopicus) is a Gram-positive soil bacterium that can produce secondary metabolites from fermentation that have a therapeutic effect. The fermented S. hygrocospicus metabolites that are still in the form of crude extracts are difficult to develop as drug preparations because the active compounds are not yet known, so it will be challenging to determine the dosage of drugs that have a therapeutic effect. Therefore, it is necessary to carry out exploratory research to narrow down the secondary metabolite profile from the fermentation of S. hygroscopicus, using extraction and fractionation methods, which are then identified by Thin-Layer Chromatography (TLC) using a combination of solvents. This study used the extraction method with a separating funnel. The fractionation was carried out using the BUCHI (Sepacore®) Flash Chromatography and Reveleris® PREP Purification System column chromatography gradually using ethyl acetate and n-hexana.  47 and 60 of the fractionation results were taken as samples, that further were profiled using TLC and given the appearance of 10% KOH stains and p-Anisaldehyde - sulfuric acid, so that various classes of compounds with different Rf values were obtained, namely Monoterpenes, Triterpenes, Steroids, Saponins, Coumarin, Scopoletin, and Alkaloids.
Red and White Galangal Puree Antioxidant Activity and Phytochemistry Screening Mardhiyyah, Kana; Yunita Intan Ryandini; Yopi Hermawan
Jurnal Jamu Indonesia Vol. 6 No. 1 (2021): Jurnal Jamu Indonesia
Publisher : Tropical Biopharmaca Research Center, IPB University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29244/jji.v6i1.174

Abstract

Antioxidant prevents oxidative stress. One of the antioxidant sources is plant. Red and white galangal are herbal plants that are easy to grow and they may have antioxidant activity. The aim of this study was to compare antioxidant activity and phytochemistry screening of red galangal (Alpinia purpurata (Vieill.) K. Schum) and white galangal (Alpinia galanga (L.) Willd.). The method of this study used was the DPPH method and qualitative analysis. The results of this study showed that the value of antioxidant activity of red galangal was significantly higher than white galangal (p<0.05). The results of phytochemistry screening showed that red galangal contained alkaloids, flavonoids, phenolics, tannins, saponins, and triterpenoids. While white galangal contained alkaloids, flavonoids, phenolics, tannins, and triterpenoids. It is can be concluded that red galangal is more effective than white galangal.
Co-Authors Ariel, Dio Giovanni Cahyono, Alfian Wika Erwan, Nabila Erina Loeki Enggar Fitri Nugraha, Rivo Yudhinata Brian Putri, Ajeng Maharani Putri, Fitria Febriliani Sri Winarsih Yopi Hermawan Yunita Intan Ryandini