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All Journal Jurnal Kedokteran Brawijaya Medical Journal of Indonesia Folia Medica Indonesiana
Erwan, Nabila Erina
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Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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Optimation of Combination of N-Hexane Solution and Ethyle Acetate on Secondary Metabolite Compounds Profile of Streptomyces hygroscopicus Ariel, Dio Giovanni; Winarsih, Sri; Putri, Fitria Febriliani; Erwan, Nabila Erina; Putri, Ajeng Maharani; Cahyono, Alfian Wika; Mardhiyyah, Kana; Fitri, Loeki Enggar; Nugraha, Rivo Yudhinata Brian
Jurnal Kedokteran Brawijaya Vol 31, No 3 (2021)
Publisher : Fakultas Kedokteran Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.jkb.2021.031.03.11

Abstract

Streptomyces hygroscopicus (S.hygroscopicus) is a Gram-positive soil bacterium that can produce secondary metabolites from fermentation that have a therapeutic effect. The fermented S. hygrocospicus metabolites that are still in the form of crude extracts are difficult to develop as drug preparations because the active compounds are not yet known, so it will be challenging to determine the dosage of drugs that have a therapeutic effect. Therefore, it is necessary to carry out exploratory research to narrow down the secondary metabolite profile from the fermentation of S. hygroscopicus, using extraction and fractionation methods, which are then identified by Thin-Layer Chromatography (TLC) using a combination of solvents. This study used the extraction method with a separating funnel. The fractionation was carried out using the BUCHI (Sepacore®) Flash Chromatography and Reveleris® PREP Purification System column chromatography gradually using ethyl acetate and n-hexana.  47 and 60 of the fractionation results were taken as samples, that further were profiled using TLC and given the appearance of 10% KOH stains and p-Anisaldehyde - sulfuric acid, so that various classes of compounds with different Rf values were obtained, namely Monoterpenes, Triterpenes, Steroids, Saponins, Coumarin, Scopoletin, and Alkaloids.
Indonesia-INTERASPIRE study: an Indonesian cross-sectional multicenter survey on cardiovascular secondary prevention in coronary heart disease Ambari, Ade Meidian; Hasan, Harris; Dwiputra, Bambang; Desandri, Dwita Rian; Hamdani, Rita; Krevani, Citra Kiki; Syaoqi, Muhammad; Ridwan, Muhammad; Anandini, Hesti; Fitra, Maha; Arso, Irsad Andi; Anggraeni, Vita Yanti; Hartopo, Anggoro Budi; Siregar, Yasmine Fitrina; Tjahjono, Cholid Tri; Tiksnadi, Badai Bhatara; Febrianora, Mega; Tarsidin, Najmi Fauzan; Arityanti, Dean; Qhabibi, Faqrizal Ria; Makes, Indira Kalyana; Susilowati, Eliana; Erwan, Nabila Erina; Hergaf, Indah Widyasari; Raynaldo, Abdul Halim
Medical Journal of Indonesia Vol. 34 No. 3 (2025): September
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.oa.257833

Abstract

BACKGROUND Cardiovascular disease (CVD) is projected to affect more than 23.3 million people by 2030. Therefore, CVD prevention strategies were established to decrease morbidity and mortality while enhancing overall well-being. The Joint European Societies (JES) guidelines on CVD prevention were developed to enhance preventive cardiology practices. This study aimed to evaluate the adherence to JES guidelines for cardiovascular prevention in routine clinical practice for secondary prevention. METHODS This multicenter cross-sectional study was conducted in 7 centers between August 2020 and June 2021. Patients under 80 years old who had undergone percutaneous transluminal coronary angioplasty, coronary artery bypass graft, percutaneous coronary intervention, or experienced acute coronary syndrome were identified from medical records and interviewed a year later. Descriptive statistics were used to calculate the occurrence of risk variables, medication use, and index events associated with low-density lipoprotein cholesterol (LDL-C), hemoglobin A1c, and blood pressure (BP). RESULTS A total of 402 participants (13.9% female) were interviewed, and their medical records were reviewed. Among the study population, 74.4% had a smoking history, 35.4% had dyslipidemia, 33.1% did not meet the BP target, and only 28.4% achieved the LDL-C target. Additionally, less than half (43.8%) participated in physical activity for >150 min/week. Only 15.6% of the patients among the centers who had scored >8 for the guideline-based target score. CONCLUSIONS Most patients did not meet the guidelines for secondary prevention, primarily due to the high prevalence of dyslipidemia and physical inactivity, although some achieved the LDL-C target.
A NETWORK META-ANALYSIS: EFFICACY AND SAFETY OF ROTATIONAL ATHERECTOMY, ORBITAL ATHERECTOMY, AND INTRAVASCULAR LITHOTRIPSY COMPARISONS FOR NODULAR CORONARY LESIONS IN PERCUTANEOUS CORONARY INTERVENTION Handayani, Riana; Oktaviono, Yudi Her; Suryawan, I Gde Rurus; Susilo, Hendri; Aziz, Karimah Khitami; Erwan, Nabila Erina
Folia Medica Indonesiana Vol. 61, No. 1
Publisher : Folia Medica Indonesiana

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

Percutaneous Coronary Intervention (PCI) has continued to evolve since its introduction in 1977. Currently, 12% of all PCI procedures for coronary artery stenosis involve Calcified Nodules (CN). CN is defined as nodular calcification that protrudes into the lumen of the coronary artery. In this era, improving the feasibility and success of PCI is essential through the use of advanced techniques, innovative approaches, and specialized devices in coronary interventions. These techniques include Rotational Atherectomy (RA), Orbital Atherectomy (OA), and Intravascular Lithotripsy (IVL). Comparisons of RA, OA, and IVL are still being extensively studied in terms of their effectiveness and safety in treating complex lesions such as CN. Given the high costs of these devices, this Network Meta-Analysis (NMA) was conducted to evaluate and compare the efficacy and safety of RA, OA, and IVL based on recent studies. The primary analysis in this study was performed using MetaInsight V6.1.1, presenting odds ratios (OR) based on a Bayesian Network Meta-Analysis and ranking the interventions according to the Surface Under the Cumulative Ranking Curve (SUCRA). The primary outcomes assessed were efficacy and safety. Efficacy was defined as the procedural success rate, and safety as the overall safety rate of each procedure. Secondary outcomes included periprocedural complications (dissection, perforation, slow flow/no-reflow, cardiac tamponade, and device failure), as well as the incidence of major adverse cardiovascular events (MACE) within 30 days. The analysis revealed a statistically significant difference in efficacy between IVL and RA, favoring IVL (OR 2.66, 95% CrI: 1.27, 6.16). However, no statistically significant differences were observed in other primary or secondary outcomes among RA, OA, and IVL. Based on SUCRA rankings, OA was the most effective in preventing MACE, while RA showed the lowest risk of periprocedural complications. Nevertheless, this network meta-analysis has several limitations due to the uncertainty of the available data. Further research, including randomized controlled trials (RCTs) or larger cohort studies with direct comparisons of all three techniques (closed-loop designs), is warranted to validate these findings.
Co-Authors Ambari, Ade Meidian Anandini, Hesti Anggoro Budi Hartopo Anggraeni, Vita Yanti Ariel, Dio Giovanni Arityanti, Dean Aziz, Karimah Khitami Badai Bhatara Tiksnadi Cahyono, Alfian Wika Cholid Tri Tjahjono Desandri, Dwita Rian Dwiputra, Bambang Febrianora, Mega Fitra, Maha Handayani, Riana Hasan, Harris Hergaf, Indah Widyasari Irsad Andi Arso, Irsad Andi Krevani, Citra Kiki Loeki Enggar Fitri Makes, Indira Kalyana Mardhiyyah, Kana Muhammad Ridwan Nugraha, Rivo Yudhinata Brian Putri, Ajeng Maharani Putri, Fitria Febriliani Qhabibi, Faqrizal Ria Raynaldo, Abdul Halim Rita Hamdani Sri Winarsih Suryawan, I Gde Rurus Susilo, Hendri Susilowati, Eliana Syaoqi, Muhammad Tarsidin, Najmi Fauzan Yasmine Fitrina Siregar Yudi Her Oktaviono, Yudi Her