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All Journal Journal of Public Health for Tropical and Coastal Region Green Medical Journal Universitas Muhammadiyah Yogyakarta Undergraduate Conference Proceeding
Asyura, Muhammad Mikail Athif Zhafir
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Civil Engineering, Building, Construction & Architecture Economics, Econometrics & Finance Education Immunology & microbiology Medicine & Pharmacology Public Health Social Sciences

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Potensi Inhibitor Protein Non-struktural 1 (NS1) Berbasis Peptida untuk Mengobstruksi Replikasi Virus Dengue (DENV): Sebuah Kajian Literatur Asyura, Muhammad Mikail Athif Zhafir; Fauzi, Ahmad; Ayub, Fakhru Adlan
Green Medical Journal Vol 3 No 1 April (2021): Green Medical Journal
Publisher : Fakultas Kedokteran Universitas Muslim Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33096/gmj.v3i1.71

Abstract

Introduction: Dengue Virus (DENV) is the pathogen for human dengue fever and is responsible for 390 million infections per year. The viral genome produces about 10 viral protein products, one of them being NS1. The NS1 protein plays a key role in viral replication and stimulation of humoral immune cells, thus being the perfect candidate to create an effective antiviral drug or vaccine for dengue Methods: Dengue Virus (DENV) is the pathogen for human dengue fever and is responsible for 390 million infections per year. The viral genome produces about 10 viral protein products, one of them being NS1. The NS1 protein plays a key role in viral replication and stimulation of humoral immune cells, thus being the perfect candidate to create an effective antiviral drug or vaccine for dengue Conclusion: The review established promising results of using peptide-based intervention on NS1. Further in vivo and randomized controlled trials are advised to solidify the applicability and biosafety of the intervention
Effectiveness Analysis of Single Dose Rifampicin-Post-Exposure Prophylaxis (SDR-PEP) as A Preventive Intervention for Leprosy Transmission: A Systematic Review of Randomized Controlled Trials Asyura, Muhammad Mikail Athif Zhafir; Wijaya, Ilma Ranjani; Toshukowong, Theetouch; Wang, Rui Sheng
Journal of Public Health for Tropical and Coastal Region Vol 4, No 2 (2021): Journal of Public Health for Tropical and Coastal Region
Publisher : Faculty of Public Health, Universitas Diponegoro, Semarang, Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14710/jphtcr.v4i2.10794

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Introduction: Leprosy is a skin disease that reaches 200,000 cases annually. Considered a neglected tropical disease, 80% of annual leprosy remained in countries such as Brazil, India, and Indonesia. Multi-drug treatment is effective in curing leprosy but ineffective in preventing further transmission. The implementation of large-scale single dose rifampicin-post exposure prophylaxis suggests the inhibition of leprosy transmission and thus needs validation.Methods: This systematic review was carried out based on the PRISMA statement from multiple databases using set keywords. A total of 646 studies were identified, followed by 4 randomized controlled trials included after screening.Results: 86,502 subjects were divided into control and interventional groups and were to be followed up in 2-6 years. Most studies showed a significant decrease of leprosy cases by 50-60%. Furthermore, a complementary effect between single-dose rifampicin-post exposure prophylaxis and Bacillus Calmette–Guérin vaccine was identified. Moreover, the cost-effectiveness of the intervention was analyzed which resulted in IDR 80,414,775 being averted in its 25th year of implementationConclusion: The review established promising results of implementing single dose rifampicin-post exposure prophylaxis to prevent leprosy transmission. Further national scale intervention with a multi-layered approach is suggested to ensure full support and continuity of the large-scale intervention 
Paternal Involvement in Maternal Healthcare: A Systematic Review of Suami SIAGA in Rural Indonesia Asyura, Muhammad Mikail Athif Zhafir; Mayhana, Shuffa Chilla; Wijaya, Ilma Ranjani; Naufal, Muhammad Afif
Proceedings of Universitas Muhammadiyah Yogyakarta Graduate Conference Vol. 1 No. 2 (2022): Engaging Youth in Community Development to Strengthen Nation's Welfare
Publisher : Universitas Muhammadiyah Yogyakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (617.143 KB)

Abstract

Introduction – Maternal health has remained as a nationwide concern especially due to Indonesia’s staggeringly high maternal mortality rate. Community development and promotion on prenatal and antenatal care has been implemented locally especially in rural areas with limited exposure to proper maternal education. Despite that, paternal understanding and involvement in maternal healthcare is a contributing factor that is commonly overlooked. Suami SIAGA is a campaign that has previously been enforced in Indonesia to promote paternal involvement pre- and post-birth with the hopes of instilling paternal responsibility and care for their partners for a better maternal outcome. Purpose – To analyse the effectiveness of the Suami SIAGA campaign in rural Indonesia as a campaign aiming to increase paternal involvement in community maternal healthcare Methodology – Literature search was conducted according to the PRISMA guidelines on international and national databases with additional materials from local university repositories until November 2020. A total of 600 studies were found with only cross-sectional studies being included. Critical appraisal of included studies was performed using the Newcastle-Ottawa Scale for quality assessment Findings – 4 peer reviewed cross-sectional studies were included in this review with a total of 55.139 couples intervened. The articles showed a positive association between the SIAGA status of husbands and improved participation in maternal healthcare especially in antenatal care visits, routine pregnancy checks and overall involvement in partners’ routines. Value– This review is the first in analysing the Suami SIAGA campaign and has valuable information in contributing to Sustainable Developmental Goals 3.7 on sexual and reproductive health
Co-Authors Ayub, Fakhru Adlan Fauzi Ahmad Muda Mayhana, Shuffa Chilla Naufal, Muhammad Afif Toshukowong, Theetouch Wang, Rui Sheng Wijaya, Ilma Ranjani