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Rani Himayani
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Education Medicine & Pharmacology Neuroscience Public Health

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Use of Tears as a Biomarker in Ocular Diseases: Use of Tears as a Biomarker in Ocular Diseases Muhammad Azzibaginda Ganie; Rani Himayani
Medula Vol 11 No 1 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i1.196

Abstract

Tears contain thousands of molecules including proteins / peptides, lipids, electrolytes, and small molecular metabolites which are secreted from the main and accessory lacrimal glands, meibomian glands, goblet cells, and eye surface epithelial cells. Tears are a source of biomarkers for eye and systemic diseases with certain advantages; in particular, non-invasive sample collection and a unique and increasingly better-defined protein composition. Biomarkers are becoming increasingly important in disease diagnosis and drug development because they have the potential to allow for more standard, objective, and precise measurement of disease and / or treatment response to therapy. The search for biomarkers is actually carried out in different body fluids, although the ideal biomarker can be found in easily accessible biological fluids, because if validated they can be searched for in a healthy population. Tears can be considered the optimal source obtained by non-invasive procedures. In recent years, scientific research has begun to focus on the study of tears for new biomarker research not only for eye diseases. In this review, presenting research on current biomarkers in tears and their relevance for clinical practice, and reports on the main results of clinical proteomics studies in eye diseases. Biomarker research in eye diseases, involving characterization of molecular and cellular components, is important to advance our understanding. about disease and developing therapy. However, this is also challenging because of the limited access to the patient's eye specimen Keywords: Essential Oils, Antibacterial, Antiviral, Antioxidant, Anti-inflammatory
Penerapan Bioteknologi DNA Rekombinan: Pengembangan Vaksinasi COVID-19 Ni Putu Pranita; Rizki Novtarina; Robby Cahyo Nugroho; Rani Himayani; Helmi Ismunandar
Medula Vol 11 No 3 (2021): Medula
Publisher : CV. Jasa Sukses Abadi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.53089/medula.v11i3.177

Abstract

The role of science and technology in all sectors is getting bigger and bigger. The development of science and technology encourages innovation in all fields including in the health sector. Specifically regarding advances in science and technology in the health sector, it relies on research by experts, including medical biotechnology. One form of utilization of medical biotechnology is the development of vaccinations. In dealing with the Covid-19 pandemic, the application of medical biotechnology can be done by developing vaccinations using recombinant DNA technology. All researchers around the world in all related fields such as genomic and structural biology experts work together to develop this vaccine. Of these several agencies, InoVio as one of the research agencies developed a DNA vaccine. The DNA vaccine has several advantages, including fast production time and formulation, can be produced in large quantities, is safer, more stable to temperature so that it is easy to store and transport. Currently the DNA vaccine for the SARS-CoV-2 virus is still in the next clinical trial phase and is mass produced for emergency use.The role of science and technology in all sectors is getting bigger and bigger. The development of science and technology encourages innovation in all fields including in the health sector. Specifically regarding advances in science and technology in the health sector, it relies on research by experts, including medical biotechnology. One form of utilization of medical biotechnology is the development of vaccinations. In dealing with the Covid-19 pandemic, the application of medical biotechnology can be done by developing vaccinations using recombinant DNA technology. All researchers around the world in all related fields such as genomic and structural biology experts work together to develop this vaccine. Of these several agencies, InoVio as one of the research agencies developed a DNA vaccine. The DNA vaccine has several advantages, including fast production time and formulation, can be produced in large quantities, is safer, more stable to temperature so that it is easy to store and transport. Currently the DNA vaccine for the SARS-CoV-2 virus is still in the next clinical trial phase and is mass produced for emergency use.
Co-Authors Anggraeni Janar Wulan Anggun Elidya Desty Marini DIMAS Arrohmansyah Fahma Azizaturrahmah Fitriani Antika Dhamayanti Ghalib Nasser Helmi Ismunandar Helmi Ismunandar Helmi Ismunandar Innou Dhanu Muhammad Azzibaginda Ganie Nabila Fatimah Az-Zahra Ni Putu Pranita Nurul Utami Ranti ayu puspita Alwi Ratu Faradhila Jonis Rizki Novtarina Robby Cahyo Nugroho Rosy Osiana Selvi Rahmawati Siti Zubaidah