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All Journal Pharmacon Journal of Health Management and Pharmacy Exploration (JOHMPE)
Lestari, Ratih Guswinda
Unknown Affiliation
Health Professions Medicine & Pharmacology Nursing Public Health Veterinary

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Phytochemical contents and diuretic activity of ethanolic extract of the red leaf lettuce (Lactuca Sativa l.) Lestari, Ratih Guswinda; Amin, Muhammad Saiful; Kusuma, Eka Wisnu
Journal of Health Management and Pharmacy Exploration Vol. 2 No. 1 (2024): February 2024
Publisher : Surya Hijau Manfaat

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.52465/johmpe.v2i1.201

Abstract

This study was conducted to evaluated of phytochemical content and diuretic activity of the red leaf lettuce. Red leaf lettuce were extracted by cold  maceration method using 70% ethanol for the 3 days and remaceration for 1 days. The phytocemical content  in ethanolic extract were evaluated by  qualitatif method. A total of 25 male rats were divided into 5 groups with CMC Na, a standard drug (furosemide 10 mg/kg), and three different doses (200, 300, and 400 mg/kg) of ethanol extract. Parameters used to determine diuresis activity include first urine latency, urine pH and cumulative urine volume. The ethanolic extract induced diuresis in a dose dependent manner as compared to the negative control. Extracts at doses of 200, 300, and 400 mg/kg produced significant diuresis effects (p<0.05) compared to negative controls with values of diuretic action 1.35; 1.43; and 1.53, respectively. In addition, there was a slightly change in the pH of urine samples of the extract-treated group compared with the negative control. Phytochemicals analysis revealed the presence of alkaloids, flavonoids, phenolics, and tannins.
Study of Liquid Self-nanoemulsifying Drug Delivery System (L-SNEDDS) that Use Oleic Acid as the Oil Phase: Literature Review Lestari, Ratih Guswinda; Sukmawati, Anita
Pharmacon: Jurnal Farmasi Indonesia Vol 21, Special Issue 1, 2024
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/pharmacon.v21i0.23468

Abstract

Self-Nanoemulsifying Drug Delivery System (SNEDDS) is a nanoemulsion system that can be used to increase the bioavailability of drugs that are hardly soluble in water and have low bioavailability. Oleic acid, a saturated fatty acid that is found in many vegetable oils, is an oil that is often used for the oil phase in SNEDDS. Therefore, this review article aims to review, study, analyze and explore the optimum formula of SNEDDS that use oleic acid as the oil phase. The articles were searched via Google Schoolar, Science Direct, and Pubmed. The total number of articles is 464 articles. The total number articles that include exclusion criteria is 453 articles. The total article that use is 11 articles. SNEDDS, which uses oleic acid as the oil phase, produces droplet sizes of 19.75-190.03 nm with a polydispersity index of 0.278-0.532. Zeta potential value, only 2 articles have a zeta potential value above +/-30, that is mefenamic acid SNEDDS and furosemide SNEDDS. Overall, SNEDDS which uses oleic acid as the oil phase has a better dissolution and bioavailability profile compared to the commercial product or the pure drug. If solubility and bioavailability increase, it can increase the pharmacological activity of the drugs
Co-Authors Anita Sukmawati Fachry Abda El Rahman Kusuma, Eka Wisnu