Article Per Year (5 Year)
p-Index From 2021 - 2026
0.444
P-Index
This Author published in this journals
All Journal Proceeding of International Conference on Biology Education, Natural Science, and Technology Journal of Biomedical Sciences and Health
Mariana, Afifah
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Chemistry Education Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Physics Public Health

Published : 2 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 2 Documents
Search

 1 
Expanding the Therapeutic Landscape: Exploring the Antimicrobial and Bioactive Potential of Mangrove-Derived Endophytic Fungi Rovik, Anwar; Mariana, Afifah; Hidayat, Galang Anahatta; Rahman, Farras Alifia
Proceeding of International Conference on Biology Education, Natural Science, and Technology 2025: Proceeding of International Conference on Biology Education, Natural Science, and Technology
Publisher : Universitas Muhammadiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar

Abstract

The escalating rise of antibiotic resistance poses a significant challenge to discovering new, effective antibiotics. This crisis represents one of the most critical threats to global health, potentially leading to a future where even minor infections could become fatal. Endophytic fungi have recently emerged as a promising source of novel bioactive compounds. This review highlights the potential of endophytic fungi isolated from mangrove vegetation to produce new antimicrobial agents. Mangrove-derived endophytic fungi are found in healthy leaves, hypocotyls, roots, stems, and flowers. The symbiotic relationship between mangrove vegetation and these fungi promotes the synthesis of diverse bioactive compounds, including newly discovered molecules such as cytospyrone, cytospomarin, penicibrocazines, thiocladospolides, coumarin, isocoumarins, and dihydroradicinin. Beyond their antimicrobial potential, these fungi also produce compounds with antifungal, antioxidant, anticancer, anti-inflammatory, anti-filarial, antibiofilm, influenza antiviral, antimycobacterial, and biological control properties. The traditional approach to antibiotic development is complex, challenging, costly, time-consuming, and labor-intensive. To overcome these obstacles, research must integrate machine learning for big data analysis and molecular-based exploration, including genomics, proteomics, and transcriptomics.
Enhanced Survival of Lactobacillus Lg71 from Mangrove Sediment Under Simulated Gastric and Intestinal Conditions Kusharyati, Dyah Fitri; Satwika, Taruna Dwi; Alfisah, Rizal Khoirun; Mariana, Afifah; Rovik, Anwar; Oedjijono, Oedjijono
Journal of Biomedical Sciences and Health Vol. 3 No. 1 (2026)
Publisher : Universitas Karya Husada Semarang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.34310/jbsh.v3.i1.291

Abstract

Background: For a probiotic to offer health benefits, it must stay viable through the tough environment of the human gastrointestinal tract. This study assesses the effectiveness of sodium alginate encapsulation in improving the survival of Lactobacillus LG71, a new strain from mangrove sediment, under simulated gastric and intestinal conditions. Objective: This study aims to evaluate the effectiveness of sodium alginate encapsulation in enhancing the viability and survival of Lactobacillus LG71, a probiotic strain isolated from mangrove sediment, during cold storage and under simulated gastric and intestinal conditions. Methods: Lactobacillus LG71 was encapsulated in sodium alginate beads. The viability of both encapsulated and free (non-encapsulated) cells was assessed over a 4-week storage period at 4 °C and during sequential exposure to simulated gastric and intestinal environments. Results: Encapsulation significantly improved survival rates compared to free cells (p < 0.05). Although both groups experienced a decline during the first week of storage, encapsulated cells maintained a high viability of approximately 107 CFU/mL, losing only 2.51 log CFU/g over four weeks. Most notably, encapsulated Lactobacillus LG71 demonstrated greater resilience during digestion, retaining populations of 2.21 log CFU/mL in gastric simulations and 1.00 log CFU/mL in intestinal simulations. In contrast, free cells were much more vulnerable to these acidic and enzymatic conditions. Conclusion: Sodium alginate encapsulation effectively protects Lactobacillus LG71 from environmental and biological stressors. These findings indicate that encapsulation is a crucial step for the commercial application of mangrove-derived probiotics, ensuring that a viable dose of living cells reaches the host's lower gastrointestinal tract to promote health benefits.
Co-Authors Alfisah, Rizal Khoirun Dyah Fitri Kusharyati Hidayat, Galang Anahatta Oedjijono Oedjijono, Oedjijono Rahman, Farras Alifia Rovik, Anwar Satwika, Taruna Dwi