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All Journal Sari Pediatri Paediatrica Indonesiana Jurnal Kedokteran STM (Sains dan Teknologi Medik)
Cesilia, Citra
Department Of Child Health, Universitas Riau Medical School/ Arifin Achmad General Hospital, Riau
Biochemistry, Genetics & Molecular Biology Education Health Professions Immunology & microbiology Medicine & Pharmacology Public Health

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Validitas dan Reliabilitas Ages & Stages Questionnaire: Social-Emotional 2 versi Indonesia Validitas dan Reliabilitas Ages & Stages Questionnaire: Social-Emotional 2 versi Indonesia Citra Cesilia; Diah Asri Wulandari; Meita Dhamayanti
Sari Pediatri Vol 22, No 6 (2021)
Publisher : Badan Penerbit Ikatan Dokter Anak Indonesia (BP-IDAI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/sp22.6.2021.343-50

Abstract

Latar belakang. Identifikasi dini gangguan sosial, emosi, dan perilaku merupakan hal penting untuk anak usia 3 tahun kebawah. Saat ini belum ada instrumen skrining untuk kelompok usia tersebut.Tujuan. Untuk menilai validitas dan reliabilitas Kuesioner Ages & Stages Questionnaire: Social-Emotional 2 versi Indonesia Metode. Studi ini merupakan studi potong-lintang yang dilakukan pada periode Agustus 2018 hingga November 2018 di Puskesmas Garuda, Bandung, Indonesia. Hasil. Sebanyak 659 dari 689 anak-anak terlibat pada studi ini. Hasil Cronbach’s alpha berkisar 0,486-0,779 sedangkan metode Split-half berkisar 0,08-0,91. Koefisien korelasi studi ini sebesar 0,68-0,95.Kesimpulan. Uji validitas ASQ:SE-2 pada usia 12-36 bulan memenuhi kriteria validitas. Uji reliabilitas menggunakan Cronbach alpha pada kelompok usia 18, 24, dan 30 bulan memiliki reliabilitas yang cukup baik, adapun pada kelompok usia 12 bulan hasil uji reliabilitas dibawah cut-off point yang menunjukkan hasil tidak reliabel.
Case report of a COVID-19 family cluster originating from a boarding school Citra Cesilia; Silvia Sudarmaji; Djatnika Setiabudi; Heda Melinda Nataprawira
Paediatrica Indonesiana Vol 61 No 1 (2021): January 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.1.2021.53-60

Abstract

Since it was first identified in Wuhan City, Hubei Province, China in December 2019, SARS-CoV-2 has spread to 195 countries and infected more than 8 million people globally. Indonesia, an archipelago consisting of thousands of islands and 34 provinces, has the largest number of confirmed cases and mortality in Southeast Asia. A total of 464 districts/cities in Indonesia have been affected by COVID-19, of which 189 districts/cities are considered to be local transmission areas. Riau Province, located in Sumatra Island, consists of 12 districts/cities with a population of more than 6.8 million. This province has the 1st largest number of COVID-19 cases on Sumatra Island. Currently, more than 3000 childrens have been infected with case fatality rate <0.3% and recovery rate >90%. In May 2020, the public health office of Riau reported that just 34 children were confirmed to have COVID-19, with symptoms varying from asymptomatic to moderate with only a few family clusters identified. During the pandemic, contact tracing is the main approach to detect and isolate sources of infection in order to reduce viral transmission. This method has also been used to control transmission of other respiratory diseases such as tuberculosis (TB), MERS, and SARS. We report here on a familial cluster of COVID-19 in the Meranti Island Regency, which is located 145 km from the city of Pekanbaru (Riau Province). The island can only be reached in four hours by speed boat.
Virologic and immunologic status of children with HIV-TB co-infections Djatnika Setiabudi; Citra Cesilia; Almira Aliyannissa; Heda Melinda Nataprawira
Paediatrica Indonesiana Vol 61 No 2 (2021): March 2021
Publisher : Indonesian Pediatric Society

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.14238/pi61.2.2021.94-9

Abstract

Background Studies about virologic and immunologic status of HIV children are lacking. Tuberculosis (TB) is the most common opportunistic infection in HIV patients and co-infection is associated with much worse prognosis. Objective To describe the virologic and immunologic status of patients with HIV and TB co-infection, before and after HIV and TB treatment. Methods A prospective study was conducted in HIV co-infected with TB patients in an Indonesian tertiary hospital between November 2016—December 2018. Viral load and CD4 levels were performed at diagnosis and after 6 months of HIV and TB treatment. Results Of 44 children hospitalized due to HIV, 15 newly diagnosed HIV cases had TB co-infection. Thirteen were included as subjects. Most patients (10/13) were under 5 years of age, with similar female and male proportions (7/13 vs. 6/13, respectively). All were diagnosed with stage 4 HIV. Six patients had respiratory problems at admission. First examinations revealed severe immunodeficiency (CD4+ <20%) in all patients, and high viral loads (>105 copies/mL) in most (9/13) patients. Despite good compliance to medications, 8/13 patients died before the sixth month follow-up. Deterioration of virologic and immunologic status was seen in 3/4 of the followed-up patients. Conclusion Children with HIV-TB coinfections have severe immunodeficiency and high viral loads. Most such patients die before 6 months, while survivors experience virologic and immunologic status deterioration. Future study must take into account for HIV drug resistance investigation.
POTENSI PEMANFAATAN MEDIA ELECTROSPUN SEBAGAI LEUKODEPLESI TERHADAP PERTUSIS BERAT DENGAN HIPERTENSI PULMONAL PADA ANAK: POTENTIAL USE OF ELECTROSPUN MEDIA AS LEUKODEPHILIN FOR SEVERE PERTUSSIS WITH PULMONARY HYPERTENSION IN CHILDREN Alparisi, Bima Diokta; Dimas, Riski; Amalia, Nindy Putri; Cesilia, Citra; Laila, Dewi Shandi; Herman, Daniel
Jurnal Kedokteran STM (Sains dan Teknologi Medik) Vol. 9 No. 1 (2026): Issue in Progress
Publisher : Fakultas Kedokteran Universitas Islam Sumatera Utara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30743/stm.v9i1.1034

Abstract

Severe pertussis in children complicated by pulmonary hypertension is a life-threatening condition caused by hyperleukocytosis, leading to pulmonary microvascular obstruction and right heart failure. Rapid leukocyte reduction is crucial to improving patient outcomes. This study employed a literature review approach using databases such as PubMed, Science Direct, and Google Scholar, focusing on publications from the last ten years discussing severe pertussis, pulmonary hypertension, leukodepletion, and electrospun nanofiber technology. Electrospun membranes made of poly(ethylene-vinyl alcohol) (EVAL) and its modifications with bovine serum albumin and glycine demonstrated leukodepletion efficiency exceeding 90%, with minimal hemolysis and preserved erythrocyte stability. Physical properties of the membrane such as pore size, fiber diameter, and water contact angle play essential roles in selective leukocyte filtration. This technology offers a non-cytotoxic and efficient alternative to conventional methods like centrifugation or chemotherapeutic induction. Electrospun nanofiber media show strong potential as a biomedical innovation for selective leukocyte reduction in severe pertussis with pulmonary hypertension, though further clinical validation is required to confirm its safety and therapeutic effectiveness. AbstrakPertusis berat pada anak dengan komplikasi hipertensi pulmonal merupakan kondisi yang mengancam jiwa akibat hiperleukositosis yang menimbulkan obstruksi mikrovaskular paru dan gagal jantung kanan. Penurunan leukosit cepat menjadi kunci dalam memperbaiki prognosis pasien. Kajian ini menggunakan pendekatan literature review melalui basis data PubMed, Science Direct, dan Google Scholar dengan kriteria inklusi artikel 10 tahun terakhir yang membahas pertussis berat, hipertensi pulmonal, leukodeplesi, dan electrospun nanofiber. Media electrospun berbasis poly(ethylene-vinyl alcohol) (EVAL) serta modifikasinya dengan bovine serum albumin dan glycine menunjukkan efisiensi leukodeplesi lebih dari 90% tanpa menimbulkan hemolisis bermakna dan mempertahankan stabilitas eritrosit. Karakteristik fisik membran seperti ukuran pori, diameter serat, dan sudut kontak air berperan penting dalam selektivitas filtrasi leukosit. Teknologi ini memberikan alternatif non-sitotoksik dibanding metode konvensional seperti sentrifugasi atau kemoterapi induksi. Media electrospun nanofiber berpotensi besar sebagai inovasi biomedis untuk menurunkan leukosit secara selektif pada pertusis berat dengan hipertensi pulmonal, meskipun masih memerlukan validasi klinis lebih lanjut.
Co-Authors Almira Aliyannissa Alparisi, Bima Diokta Amalia, Nindy Putri Dewi Shandi Laila, Dewi Shandi Diah Asri Wulandari Dimas, Riski Djatnika Setiabudi Heda Melinda Nataprawira Heda Melinda Nataprawira Herman, Daniel Meita Dhamayanti Silvia Sudarmaji