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Perdanakusuma, David S

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Author-ID : 1803438

Civil Engineering, Building, Construction & Architecture Other

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Scars, The Surgeons’ Overlooked Threat From Hero to Zero Perdanakusuma, David S
Jurnal Plastik Rekonstruksi Vol. 2 No. 3 (2013): Jurnal Plastik Rekonstruksi
Publisher : Lingkar Studi Bedah Plastik Foundation

Scar is a reminding mark left by surgeons on patients who presented with wounds or required surgery. In healing process, due to some circumstances and individual traits, wounds could become bad scars that would definitely affect the patient’s appearance and cause many complaints. In the first years after treatment, surgeons will be commemorated as heroes who once helped the patients to overcome and cure the disease. After a few years, the memory of the surgeon’s heroic action will gradually dissipate with the formation of a bad scar. Such good memory will be replaced with persistent complaints arising from the scar such as deformity, pain, itchiness and enlargement of the lesion. Several efforts have been made to manage disturbing scars however they often do not yield satisfactory result and moreover sometimes the scars will enlarge, become unpleasant and more disturbing. This will frustrate the patient as well as the surgeon. The good memory of the surgeon as a hero has shifted into one whose surgical procedure was regretted. Presently, there are about 25 modalities using various approaches for scar treatment. These manifold choices indicate that the available modalities have been generally inadequate and the therapeutic response very variable. Furthermore, treatment selection is also based on recurrence. Most of the available therapeutic modalities in this stage are nonsurgical. There is also topical treatment mostly containing herbal extract, which is considered inadequate and lacking of evidence base. Corticosteroid injection and silicone gel is a nonsurgical method recommended and supported by evidence based. This technique is largely chosen by doctors. Combined therapy is the method of choice believed to yield optimal result. Let us remain heroes by paying attention to scars.

MECHANISM OF APOPTOSIS INHIBITION TO SQUAMOUS CELL CARCINOMA OF ORAL CANCER IN CISPLATIN TREATMENT Dwi Wibowo, R Marjono; Perdanakusuma, David S; Tanggo, Eddy Herman
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

This study was to approve the increased secretion of Hsp 70, DNA damage, and inhibitor apoptosis protein in cisplatin therapy which influence apoptosis of oral cancer cell and to know mechanism of molecular pathology. This study was an in vitro experimental laboratory using Randomized Block Design. Cell culture of oral cancer divided from cisplatin resistance cancer cell and cancer cell never induce cisplatin. Two group of cancer cell would be given cisplatin therapy. Secretion of Hsp 70, DNA damage, Inhibitor of apoptosis protein, and apoptosis index would be examined. Cisplatin resistance cancer cell group showed lower apoptosis than never induce cisplatin cancer cell. Elevated secretion of Hsp 70 in cisplatin therapy group (p= 0.000, b=0.881). Lower secretion of DNA damage protein in cisplatin resistance cancer cell and it was not going apoptosis. In path regression analysis, cisplatin was significans through IAP pathway (p=0.000, b=0.726) to apoptosis. All type of cell cultures were also significans through IAP pathway (p=0.000, b=0.496) to apoptosis. Elevated IAP secretion influenced apoptosis (b= 1.000). In conclusion, cisplatin used IAP pathway to apoptosis. All type of cell cultures also used IAP pathway to apoptosis. Cisplatin resistance cell culture had stronger effect to IAP and IAP increased inhibition to apoptosis.

Effectiveness of Pre PRP Injection and Post Elevation Flap at Extended Random Flap Rat Skin Sudrajat Wahyu Nugroho, Thomas Eduardus; Rizaliyana, Sitti; Perdanakusuma, David S
Folia Medica Indonesiana Vol. 56 No. 3 (2020): September
Publisher : Universitas Airlangga

Background:Closure of the defect with a random skin flap is constrained by the extent of the defect area. Several studies have shown the benefits of administration of PRP (Platelet Rich Plasma) in random skin flap. The purpose of this study is to compare the effect of PRP injection given before flap elevation, after flap elevation and control on the extended random skin flap procedures in rats.Methods: This research is experimental with randomized post test only control group design (n = 27, divided into 3 treatment groups) that compare the effectiveness of PRP injection 24 hours prior to the elevation of the flap, after the elevation of the flap, and control in the extended random skin flap in rats. Random skin flap is made in the ratio 1: 5 on the rat skin. Measurement of viable area were observed on days 1, 7 and 14.Results: There were significantly increased viability of random skin flap on the group with PRP injection 24 hours prior flap elevation compared to other group of treatment. The average of viability on day first 39%±13% ;42%±34%; 62%±14%. On day 7th24%±13%; 36%±26%; 62%±12%.On day 14th16%±15%; 28%±22%; 60%±11%.Conclusion: Injection of PRP on extended random skin flap on rat 24 hours before flap elevationincrease viability of the flap compared to control group and group which receive PRP injection on extended random flap on rat skin after elevation of the flap. Viability increased due to angiogenesis stimulation after PRP injection.

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