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Hubungan antara Pemakaian KB Hormonal dengan Kejadian Kanker Payudara di Poli Onkologi Satu Atap RSUD Dr. Soetomo, FebruariApril 2015 SETIOWATI, DITYA AYU INTAN; TANGGO, EDDY HERMAN; SOEBIJANTO, ROOSTANTIA INDRAWATI
Indonesian Journal of Cancer Vol 10, No 1 (2016): Jan - Mar 2016
Publisher : Indonesian Journal of Cancer

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (313.309 KB)

ABSTRACTThe aim of this study is to search relationship between using of hormonal contraception and breast cancer incidence. This study uses observational analytic method with case contol design. Group case is the women in POSA RSUD Dr. Soetomo diagnosed as breast cancer patient. Group control is the women in POSA RSUD Dr. Soetomo who are not diagnosed breast cancer. Then, calculate the Odds Ratio using 2x2 crosstabulation and p value using chi square statistictest with SPSS program. There are 96 women of case group sample and 96 women of control group sample are used in this study. Calculation of regression logistic multivariate analysis shows that there is significant relationship between using hormonal contraception and breast cancer incidence in POSA RSUD Dr. Soetomo with p=0.001, OR=2.990, woman who uses hormonal contraception has 2.990 times risk bigger than the woman who doesnt use hormonal contraception. There is significant relationship between using hormonal contraception and breast cancer incidence inPOSA RSUD Dr. Soetomo and woman who uses hormonal contraception has 2,304 times risk bigger than the woman who doesnt.ABSTRAKTujuan dari penelitian ini adalah untuk mengetahui hubungan antara pemakaian KB hormonal dengan kejadian kanker payudara. Penelitian ini menggunakan metode analisis dengan desain kasus kontrol. Kelompok kasus adalah wanita di POSA RSUD Dr. Soetomo yang menderita kanker payudara, dan kelompok kontrol adalah wanita di POSA RSUD Dr. Soetomo yang tidak menderita kanker payudara. Kemudian Rasio Odds dihitung menggunakan tabel 2x2 dan nilai p menggunakan tes chi square dengan program SPSS. Ada 96 kelompok kasus dan 96 kelompok kontrol yang ada dalampenelitian ini. Setelah dihitung dengan analisis multivariat regresi logistik menunjukkan bahwa ada hubungan bermakna antara penggunaan KB hormonal dengan kejadian kanker payudara pada wanita di POSA RSUD Dr. Soetomo dengan nilai p= 0,001 dan OR=2,990 yang berarti wanita yang menggunakan KB hormonal memiliki risiko 2,990 kali lebih besar terkena kanker payudara dibanding yang tidak menggunakan. Kesimpulannya, ada hubungan bermakna antara pemakaian KB hormonal dengan kejadian kanker payudara pada wanita di POSA RSUD Dr. Soetomo dan wanita yang menggunakan KB hormonal memiliki risiko 2,990 kali lebih besar terkena kanker payudara dibanding yang tidak menggunakan.

The Relationship between Recurrence Rate and Molecular Subtypes of Breast Cancer in Locally Advance Breast Cancer (LABC) Post Mastectomy: Focus on Comparison of Luminal A and Luminal B Eric Hartoyo Salim; Eddy Herman Tanggo; Dwi Hari Susilo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.359

Background. Breast cancer is the highest prevalence of malignancy for women in Indonesia and important national health problem. Estimated 2 million women developed breast cancer in 2018 with a mortality rate of 14.1 in every 100,000 women. Regarding the relationship between subtypes and breast cancer recurrence Several studies on gene expression have shown several subtypes of breast cancer, including the two most important subtypes, estrogen receptor (ER) positive (Luminal A and Luminal B) and ER negative (Triple negative and Her2 positive). Based on the explanation above, currently there is no data in Soetomo Hospital that discusses the role of breast cancer subtypes as a prognostic factor in determining the recurrence rate in locally advanced breast cancer.Methods. The research design is an associative test using a retrospective cohort observational analytical study design, associating the relationship between tumor subtypes with recurrence in locally advanced breast cancer patients after mastectomy and has received additional therapy according to standard procedures at Dr. Soetomo Surabaya This study used secondary data from the medical records of the Oncology Polyclinic, RSUD Dr. Soetomo Surabaya from 2014 to 2019.Results. The research subjects who have been selected according to inclusion criteria are 214 people, with the proportion in the population of luminal A and luminal B subtypes of 107 people each. Based on this study, it was found that the subtype was positively correlated with recurrence in LABC patients who had undergonecmastectomy with a significance value of p = 0.000 (p <0.05; 99% CI).Conclusion. There is a relationship between the recurrence rate and the molecular subtype of breast cancer in locally advanced breast cancer (LABC) patients after mastectomy at Dr Soetomo Hospital.

The Relationship between Recurrence Rate and Molecular Subtypes of Breast Cancer in Locally Advance Breast Cancer (LABC) Post Mastectomy: Focus on Comparison of Luminal A and Luminal B Eric Hartoyo Salim; Eddy Herman Tanggo; Dwi Hari Susilo
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 5 No. 10 (2021): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/bsm.v5i10.359

Background. Breast cancer is the highest prevalence of malignancy for women in Indonesia and important national health problem. Estimated 2 million women developed breast cancer in 2018 with a mortality rate of 14.1 in every 100,000 women. Regarding the relationship between subtypes and breast cancer recurrence Several studies on gene expression have shown several subtypes of breast cancer, including the two most important subtypes, estrogen receptor (ER) positive (Luminal A and Luminal B) and ER negative (Triple negative and Her2 positive). Based on the explanation above, currently there is no data in Soetomo Hospital that discusses the role of breast cancer subtypes as a prognostic factor in determining the recurrence rate in locally advanced breast cancer.Methods. The research design is an associative test using a retrospective cohort observational analytical study design, associating the relationship between tumor subtypes with recurrence in locally advanced breast cancer patients after mastectomy and has received additional therapy according to standard procedures at Dr. Soetomo Surabaya This study used secondary data from the medical records of the Oncology Polyclinic, RSUD Dr. Soetomo Surabaya from 2014 to 2019.Results. The research subjects who have been selected according to inclusion criteria are 214 people, with the proportion in the population of luminal A and luminal B subtypes of 107 people each. Based on this study, it was found that the subtype was positively correlated with recurrence in LABC patients who had undergonecmastectomy with a significance value of p = 0.000 (p <0.05; 99% CI).Conclusion. There is a relationship between the recurrence rate and the molecular subtype of breast cancer in locally advanced breast cancer (LABC) patients after mastectomy at Dr Soetomo Hospital.

Hubungan antara Pemakaian KB Hormonal dengan Kejadian Kanker Payudara di Poli Onkologi Satu Atap RSUD Dr. Soetomo, FebruariApril 2015 DITYA AYU INTAN SETIOWATI; EDDY HERMAN TANGGO; ROOSTANTIA INDRAWATI SOEBIJANTO
Indonesian Journal of Cancer Vol 10, No 1 (2016): Jan - Mar 2016
Publisher : National Cancer Center - Dharmais Cancer Hospital

ABSTRACTThe aim of this study is to search relationship between using of hormonal contraception and breast cancer incidence. This study uses observational analytic method with case contol design. Group case is the women in POSA RSUD Dr. Soetomo diagnosed as breast cancer patient. Group control is the women in POSA RSUD Dr. Soetomo who are not diagnosed breast cancer. Then, calculate the Odds Ratio using 2x2 crosstabulation and p value using chi square statistictest with SPSS program. There are 96 women of case group sample and 96 women of control group sample are used in this study. Calculation of regression logistic multivariate analysis shows that there is significant relationship between using hormonal contraception and breast cancer incidence in POSA RSUD Dr. Soetomo with p=0.001, OR=2.990, woman who uses hormonal contraception has 2.990 times risk bigger than the woman who doesnt use hormonal contraception. There is significant relationship between using hormonal contraception and breast cancer incidence inPOSA RSUD Dr. Soetomo and woman who uses hormonal contraception has 2,304 times risk bigger than the woman who doesnt.ABSTRAKTujuan dari penelitian ini adalah untuk mengetahui hubungan antara pemakaian KB hormonal dengan kejadian kanker payudara. Penelitian ini menggunakan metode analisis dengan desain kasus kontrol. Kelompok kasus adalah wanita di POSA RSUD Dr. Soetomo yang menderita kanker payudara, dan kelompok kontrol adalah wanita di POSA RSUD Dr. Soetomo yang tidak menderita kanker payudara. Kemudian Rasio Odds dihitung menggunakan tabel 2x2 dan nilai p menggunakan tes chi square dengan program SPSS. Ada 96 kelompok kasus dan 96 kelompok kontrol yang ada dalampenelitian ini. Setelah dihitung dengan analisis multivariat regresi logistik menunjukkan bahwa ada hubungan bermakna antara penggunaan KB hormonal dengan kejadian kanker payudara pada wanita di POSA RSUD Dr. Soetomo dengan nilai p= 0,001 dan OR=2,990 yang berarti wanita yang menggunakan KB hormonal memiliki risiko 2,990 kali lebih besar terkena kanker payudara dibanding yang tidak menggunakan. Kesimpulannya, ada hubungan bermakna antara pemakaian KB hormonal dengan kejadian kanker payudara pada wanita di POSA RSUD Dr. Soetomo dan wanita yang menggunakan KB hormonal memiliki risiko 2,990 kali lebih besar terkena kanker payudara dibanding yang tidak menggunakan.

MECHANISM OF APOPTOSIS INHIBITION TO SQUAMOUS CELL CARCINOMA OF ORAL CANCER IN CISPLATIN TREATMENT Dwi Wibowo, R Marjono; Perdanakusuma, David S; Tanggo, Eddy Herman
Folia Medica Indonesiana Vol. 53 No. 1 (2017): JANUARY - MARCH 2017
Publisher : Universitas Airlangga

This study was to approve the increased secretion of Hsp 70, DNA damage, and inhibitor apoptosis protein in cisplatin therapy which influence apoptosis of oral cancer cell and to know mechanism of molecular pathology. This study was an in vitro experimental laboratory using Randomized Block Design. Cell culture of oral cancer divided from cisplatin resistance cancer cell and cancer cell never induce cisplatin. Two group of cancer cell would be given cisplatin therapy. Secretion of Hsp 70, DNA damage, Inhibitor of apoptosis protein, and apoptosis index would be examined. Cisplatin resistance cancer cell group showed lower apoptosis than never induce cisplatin cancer cell. Elevated secretion of Hsp 70 in cisplatin therapy group (p= 0.000, b=0.881). Lower secretion of DNA damage protein in cisplatin resistance cancer cell and it was not going apoptosis. In path regression analysis, cisplatin was significans through IAP pathway (p=0.000, b=0.726) to apoptosis. All type of cell cultures were also significans through IAP pathway (p=0.000, b=0.496) to apoptosis. Elevated IAP secretion influenced apoptosis (b= 1.000). In conclusion, cisplatin used IAP pathway to apoptosis. All type of cell cultures also used IAP pathway to apoptosis. Cisplatin resistance cell culture had stronger effect to IAP and IAP increased inhibition to apoptosis.

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