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All Journal Jurnal Farmasi Medica (Pharmacy Medical Journal) PMJ Malacca Pharmaceutics
Kalalo, Marko Jeremia
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemistry Immunology & microbiology Medicine & Pharmacology Public Health

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POTENSI ANTIMIKROBA CENGKEH : REVIEW LITERATUR Kalalo, Marko Jeremia; Gratia, Berta; Bidulang, Crunny Bidhya; Djafar, Fadillah; Edy, Hosea Jaya
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 3, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (785.643 KB) | DOI: 10.35799/pmj.3.2.2020.32882

Abstract

ABSTRACT Popularity of bioactive compounds from plants as a treatment for microbial infections have increased. The content of chemical compounds in cloves can produce various biological activities. The chemical compounds contained in cloves are phenol, flavonoid, hydroxybenzoate, and hydrokinetic acid, with the main chemical compound being eugenol. This review was prepared using secondary data from the scientific literature databases of Google Scholar, PubMed, and CORE. This review aims to collect, compile, study, and highlight the potential of cloves as an antimicrobial agent from existing literature and databases. The effectiveness of cloves in treating microorganisms has a broad spectrum, including bacteria, fungi, protozoa, and viruses. The antimicrobial activity of ethanol, methanol, acetone extract, and clove essential oil provided antimicrobial activity against Gram-positive and Gram-negative bacteria. Cloves show bacteriostatic and bacteriocidic activity with mechanism of action in disrupting or damaging cell wall. Keywords : antimicrobial, clove.   ABSTRAKPopularitas senyawa bioaktif tanaman sebagai penanganan infeksi mikroba kian meningkat. Kandungan senyawa kimia cengkeh dapat menghasilkan berbagai aktivitas biologi. Senyawa kimia yang terkandung dalam cengkeh adalah fenol, flavonoid, hidroksi benzoat, dan asam hidrokinetik, dengan kandungan senyawa kimia utama eugenol. Review ini dibuat menggunakan data sekunder dari database literatur ilmiah Google Scholar, PubMed, dan CORE. Review ini bertujuan untuk mengumpulkan, menyusun, mengkaji, dan menyorot potensi cengkeh sebagai agen antimikroba dari literatur dan database yang ada. Efektivitas cengkeh dalam menghabat mikroorganisme memiliki spektrum yang luas mencakup bakteri, jamur, protozoa, dan virus. Aktivitas antimikroba ekstrak etanol, metanol, aseton, minyak atsiri cengkeh memberikan aktivitas antimikroba pada bakteri Gram positif dan Gram negatif. Cengkeh menunjukkan aktivitas bakteriostatik dan bakteriosidik dengan mekanisme merusak dinding sel. Kata kunci : antimikroba, cengkeh
TEA BIOACTIVE COMPOUNDS AS INHIBITOR OF MRSA PENICILLIN BINDING PROTEIN 2a (PBP2a): A MOLECULAR DOCKING STUDY Kalalo, Marko Jeremia; Fatimawali, Fatimawali; Kalalo, Tekla; Rambi, Christani I J
Jurnal Farmasi Medica/Pharmacy Medical Journal (PMJ) Vol 3, No 2 (2020)
Publisher : Sam Ratulangi University

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (896.914 KB) | DOI: 10.35799/pmj.3.2.2020.32878

Abstract

ABSTRACT Methicillin-Resistant Staphylococcus aureus (MRSA) is a hypervirulent multidrug- resistant bacteria. It is spreading around the globe and starting to be a global health problem. It causes bacteremia, infective endocarditis, and bloodstream infection. PBP2a is a protein responsible for MRSA’s resistance to antibiotics, especially beta-lactams. Tea contains bioactive compounds such as polyphenols. It is known to have great antibacterial activities. Therefore, this study aims to find potentials antibacterial compounds from tea polyphenols that can inhibit PBP2a in MRSA with better binding energy than the currently available drugs using the molecular docking approach. We found that theaflavin (-9,7 kcal/mol), as one of the tea polyphenols compound, has a better binding energy with ceftaroline (9,5 kcal/mol) therefore predicted to have better antibacterial activity. (−)- Epigallocatechingallate (-9,1 kcal/mol), (−)-epicatechingallate (-8,8 kcal/mol), myricetin (- 8,7 kcal/mol), quercetin (-8,5 kcal/mol), (−)-epicatechin (-8,3 kcal/mol), (−)- epigallocatechin (-8,3 kcal/mol), kaempferol (-8,3 kcal/mol), procyanidin B2 (-8,1), and theflavindigallate (-7,6 kcal/mol) also have the potential to inhibit MRSA due to its low binding energy. Key words : Molecular docking, MRSA, PBP2a, Tea polyphenols.
In Vitro Antioxidant Activity of Chrysanthemum indicum Flowers Extract and Its Fraction Dolongtelide, Jeclin Inebel; Fatimawali, Fatimawali; Tallei, Trina Ekawati; Suoth, Elly Juliana; Simbala, Herny Emma Inonta; Antasionasti, Irma; Kalalo, Marko Jeremia
Malacca Pharmaceutics Vol. 1 No. 2 (2023): October 2023
Publisher : Heca Sentra Analitika

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.60084/mp.v1i2.26

Abstract

Chrysanthemum indicum L., commonly known as Chrysanthemum flower, is an herbaceous plant that has a long-established history of medicinal usage. There has been extensive research about C. indicium L, especially about its antioxidant activities, but not much has been done on its fraction. This study aimed to explore the efficacy of the ethanol extract and its fraction derived from Chrysanthemum flowers in scavenging free radicals. The antioxidant potential of the ethanol extract, as well as its aqueous and n-hexane fractions, was evaluated using the 2,2-diphenyl-1-picrilhidrazine (DPPH) method in vitro. The degree of antioxidant activity was quantified by determining the IC50 value, which corresponds to the concentration of the extract or fractions required to inhibit 50% of DPPH free radicals. The results obtained from this investigation provide strong evidence that the ethanolic extract, as well as its aqueous and n-hexane fractions, exhibited significant antioxidant activity. The measured IC50 values for the ethanolic extract, aqueous fraction, and n-hexane fraction were 1.350 µg/mL, 1.109 µg/mL, and 7.588 µg/mL, respectively.
Co-Authors Antasionasti, Irma Bidulang, Crunny Bidhya Djafar, Fadillah Dolongtelide, Jeclin Inebel Elly Suoth Fatimawali . Gratia, Berta Herny E.I. Simbala Hosea Jaya Edy Kalalo, Tekla Rambi, Christani I J TRINA EKAWATI TALLEI