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All Journal Indonesian Journal of Medicine Jurnal Pengabdian Masyarakat Medika
Rakhma, Titian
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Medicine & Pharmacology Public Health

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Relationship between APO-A, APO-B, and C-reactive Protein with Depression in Epileptic Patients Mirawati, Diah Kurnia; Widhianingsih, Nella Lusti; Rakhma, Titian; Subandi, Subandi; Danuaji, Rivan; Budianto, Pepi; Prabaningtyas, Hanindya Riani; Putra, Stefanus Erdana
Indonesian Journal of Medicine Vol. 5 No. 4 (2020)
Publisher : Masters Program in Public Health, Universitas Sebelas Maret, Indonesia

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Abstract

Background: Epilepsy is one of the oldest neurological disease requiring long-term treat­ment. Long-term use of certain anti-epileptic drugs (AED) will strongly induce cytochrome-P450 (CYP) enzyme resulting increase of homo­cysteine associated with risk of cerebrovascular disease and depression. The purpose of this study was to determine relationship between serum level of ApoA, ApoB, and C-Reactive Protein (CRP) with depression in epileptic patients receiving AED therapy.Subjects and Method: Respondents of this cross-sectional study were epileptic outpatients in neurology clinic Dr. Moewardi Hospital, Surakarta receiving AED therapy and met inclusion and exclusion criteria. Depression condition was evaluated by Hamilton Depress­ion Rating Scale (HDRS). Serum level of ApoA, ApoB, and CRP of each respondent were mea­sured from vein blood. Data were analyzed by a multiple linear regression.Results: There were 51 epileptic patients with proportional ratio between men and women (1.2:1) with age range from 18 to 59 years old. The average length of AED 92.67 months (Mean= 92.67; SD= 91.58). Average of HDRS score was 8.49. Meanwhile, average of ApoA level was 86.14 mg/dL, average of ApoB level was 47.57 mg/dL, and average of CRP level was 0.18 mg/dL. Serum level of ApoA, ApoB, and CRP increased depression (HDRS score) in epileptic patients.Conclusion: There was a statistically signi­fi­cant relationship between serum level of ApoA, ApoB, and CRP with depressive condi­tion of epileptic patients receiving long-term AED treatment.Keywords: ApoA, ApoB, C-Reactive Protein, depression, epilepsyCorrespondence: Diah Kurnia Mirawati. Neurology Department of Dr. Moewardi Regional General Hospital/ Medical Faculty of Universitas Sebelas Maret, Indonesia. Email: diahkm@staff.uns.ac.id.Indonesian Journal of Medicine (2020), 05(04): 282-290https://doi.org/10.26911/theijmed.2020.05.04.03. 
PENYULUHAN PENCEGAHAN STROKE DAN FAKTOR RISIKONYA PADA LANSIA: Education on Stroke Prevention and Its Risk Factors in Elderly Rakhma, Titian; Dewi, Listiana Masyita; Putri, Nabilla Munanda; Ruspita, Wiza Sarlia; Madania, Makiyatul; Khusna, Syafira Anggraini; Fadhilah, Nurul; Feriyanto, Dedek Dani
Jurnal Pengabdian Masyarakat Medika Vol 3. No. 1, Maret 2023
Publisher : Universitas Muhamamdiyah Surakarta

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.23917/jpmmedika.v3i1.1316

Abstract

ABSTRAK Stroke merupakan penyakit defisit neurologis yang disebabkan oleh perdarahan ataupun sumbatan yang dapat menimbulkan kecacatan ataupun kematian. Di dunia stroke menduduki urutan kedua penyebab kematian dan urutan keenam penyebab kecacatan. Prevalensi stroke di Indonesia tahun 2018 sebanyak 10,9%. Di Jawa Tengah menduduki peringkat kedua jumlah penderita stroke. Kabupaten Sukoharjo sendiri memiliki kasus stroke hemorrhagi terbanyak dibandingkan kabupaten lain sebanyak 14,9%. Pentingnya untuk mencegah dan mengontrol faktor risiko stroke. Penyuluhan diadakan dalam rangka memberikan informasi kepada masyarakat mengenai pencegahan stroke dan faktor risikonya. Langkah yang digunakan adalah dengan memberikan materi dan pretes-postes. Pretes dan postest bertujuan untuk mengetahui pengetahuan dari peserta penyuluhan mengenai pencegahan stroke dan faktor risikonya. Perbandingan dari rata-rata jawaban benar pre-test sebesar 40,35% dan postes sebesar 83 92%.  Hasil yang didapat dinilai menggunakan uji Normalitas dan homogenitas dan uji T berpasangan, didapatkan nilai p < 0,005. Hal ini menunjukkan adanya peningkatan pengetahuan setelah diberikannya materi oleh pemateri. Oleh karena itu, kegiatan penyuluhan ini berhasil meningkatkan pengetahuan mengenai pencegahan stroke dan factor risikonya pada lansia. ABSTRACT A stroke is a neurological deficit disease caused by bleeding or blockage that can cause disability or death. In the world, stroke is the second leading cause of death and the sixth leading cause of disability. The prevalence of stroke in Indonesia in 2018 was 10.9%. In Central Java, it ranks second in the number of stroke sufferers. Sukoharjo district itself has the most cases of hemorrhagic stroke compared to other districts as much as 14.9%. The importance of preventing and controlling stroke risk factors. Counseling is held to provide information to the public regarding stroke prevention and risk factors. The steps used are to provide material and pretest-posttest. The pretest and posttest aim to determine the knowledge of the counseling participants regarding stroke prevention and risk factors. The comparison of the average correct answers for the pre-test was 40.35% and the post-test was 83-92%. The results obtained were assessed using normality and homogeneity tests and paired t-tests, obtaining p value < 0.005. This shows an increase in knowledge after the material is given by the speaker. Therefore, this outreach activity succeeded in increasing knowledge about stroke prevention and risk factors in the elderly.
Co-Authors Budianto, Pepi Damayanti, Elok Diah Kurnia Mirawati Feriyanto, Dedek Dani Khusna, Syafira Anggraini Listiana Masyita Dewi Madania, Makiyatul Nurul Fadhilah Prabaningtyas, Hanindya Riani Putri, Nabilla Munanda Rivan Danuaji Ruspita, Wiza Sarlia Stefanus Erdana Putra Widhianingsih, Nella Lusti