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All Journal Callosum Neurology Journal : Jurnal Berkala Neurologi Bali ISM (Intisari Sains Medis) : Jurnal Kedokteran AKSONA
Ardiansyah, Djohan
Department Of Neurology, Faculty Of Medicine Airlangga University/Dr. Soetomo General Hospital, Surabaya, East Java, Indonesia
Biochemistry, Genetics & Molecular Biology Health Professions Medicine & Pharmacology Neuroscience

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DIFFERENCES OF TEMOZOLAMIDE RESPONSE IN GLIOBLASTOMA MULTIFORME: REPORT OF TWO CASES Djohan Ardiansyah; Vita Kusuma Rahmawati; Sri Andreani Utomo
Callosum Neurology Vol 3 No 3 (2020): Callosum Neurology Journal
Publisher : The Indonesia Neurological Association Branch of Denpasar

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29342/cnj.v3i3.89

Abstract

Background: Glioblastoma multiforme (GBM) is about 20% of primary adult brain neoplasms which has poor prognosis; life expectancy is no more than 12 months after the diagnosis. Temozolomide (TMZ) has become GBM standard therapy, combined with the surgery and radio-chemotherapy. Evaluation is important since its relation with the continuity or termination of therapy. Several studies are improving to measure therapy response of GBM. Response Assessment in Neuro-Oncology (RANO) criteria which is published in 2010, became a major criterias to evaluate TMZ response in patients with GBM. This criteria combines clinical manifestation, steroid therapy, and brain magnetic resonance imaging (MRI). Case: We report two GBM cases with standard management. Two women in productive ages and specific clinical manifestations, diagnosed with GBM in left temporal lobes. A 24-year-old woman showed complete response; while a-41-year old one showed progressive response. Discussion: We analyze TMZ response based on RANO criteria. Prognostic factors that differentiate TMZ response in both cases were presence of comorbidity, intratumoral hemorrhage on MRI, and surgery initiation in early diagnosis. Conclusion: Based on RANO criteria and prognostic factors which support TMZ response, the role of adjuvant TMZ become important in standard management of GBM. Keywords: Glioblastoma Multiforme, Response Assessment in Neuro-Oncology, Temozolomide.
Hubungan intensitas nyeri dengan kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo Duta Angela; Djohan Ardiansyah; Desak Gede Agung Suprabawati
Intisari Sains Medis Vol. 13 No. 1 (2022): (Available Online : 1 April 2022)
Publisher : DiscoverSys Inc.

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (634.05 KB) | DOI: 10.15562/ism.v13i1.1236

Abstract

Introduction: Breast cancer occurs because breast cells grow out of control. The incidence of breast cancer is still very high both in developed countries and in Indonesia. One treatment that can be done is chemotherapy. Pain is one of the effects that can occur in undergoing chemotherapy, besides the increasing stage of cancer can increase pain. This increased pain often affects a person's quality of life. This study aims to determine the relationship between pain intensity and quality of life of breast cancer patients undergoing chemotherapy at PPLK RSUD Dr. Soetomo.Methods: This research is a descriptive analytical study with a cross-sectional method. Sampling was done by total sampling that met the inclusion and exclusion criteria, then filled out the Sf-36 questionnaire and the Wong Baker pain scale. Forty respondents with breast cancer underwent chemotherapy at PPLK RSUD Dr. Soetomo. Analysis using SPSS. The Shapiro Wilk test was used to determine the normality test. Correlation using Spearman's test.Results: From 40 respondents, the youngest age in this study was 29 years old and the oldest was 61 years old. The highest level of pain in stage 4 breast cancer patients is in the mildly disturbing category, which is measured using the Wong Baker scale. The results of the Spearman test concluded that there were significant results between pain intensity and quality of life. There are 8 components in assessing the quality of life with the SF-36: physical function, physical role, emotional role, energy, mental health, social function, pain, and general health (p<0.05).Conclusion: This study shows a relationship between pain intensity and quality of life of breast cancer patients undergoing chemotherapy.  Pendahuluan: Kanker payudara terjadi karena sel-sel payudara tumbuh di luar kendali. Angka kejadian kanker payudara masih sangat tinggi baik di negara maju maupun Indonesia. Salah satu pengobatan yang dapat dilakukan adalah kemoterapi. Nyeri merupakan salah satu efek yang dapat terjadi dalam menjalani kemoterapi, selain itu stadium kanker yang meningkat dapat meningkatkan rasa nyeri. Nyeri yang meningkat ini seringkali memengaruhi kualitas hidup seseorang. Penelitian ini bertujuan untuk mengetahui hubungan intensitas nyeri terhadap kualitas hidup pasien kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo.Metode: Penelitian ini merupakan penelitian deskripsi analitik dengan metode cross-sectional. Pengambilan sampel dilakukan dengan cara total sampling yang memenuhi kriteria inklusi dan eksklusi, kemudian dilakukan pengisian kuisioner Sf-36 dan skala nyeri Wong Baker. Terdapat 40 responden penderita kanker payudara yang menjalani kemoterapi di PPLK RSUD Dr. Soetomo. Analisis menggunakan SPSS. Uji Shapiro Wilk digunakan untuk menentukan uji normalitas. Korelasi hubungan menggunakan uji Spearman.Hasil: Dari 40 responden diperoleh hasil dengan usia termuda dalam penelitian ini berumur 29 tahun dan tertua berumur 61 tahun. Tingkatan nyeri tertinggi pada pasien kanker payudara stadium 4 masuk dalam kategori agak mengganggu, yang diukur menggunakan skala Wong Baker. Hasil uji Spearman menyimpulkan adanya hasil yang signifikan antara intensitas nyeri dengan kualitas hidup. Terdapat 8 komponen dalam menilai kualitas hidup dengan SF-36, yaitu fungsi fisik, peranan fisik, peranan emosi, energi, kesehatan jiwa, fungsi sosial, rasa nyeri, dan kesehatan umum (p<0,05).Kesimpulan: Penelitian ini menunjukkan adanya hubungan antara intensitas nyeri dan kualitas hidup pasien kanker payudara yang sedang menjalani kemoterapi.
Profile of Meningioma Patients at Dr. Soetomo General Academic Hospital Valeryna, Natasha; Ardiansyah, Djohan; Susanto, Joni; Utomo, Sri Andreani
AKSONA Vol. 4 No. 2 (2024): JULY 2024
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v4i2.53334

Abstract

Highlight: Meningioma, the most common primary brain tumor, is typically found in women aged 40-49 years old. Meningiomas can show distinctive characteristics on clinical, radiological, and histopathological examinations. There were significant differences in histopathological grading between male and female patients, as well as between homogenous and heterogenous contrast enhancement.   ABSTRACT Introduction: Meningioma is an intracranial extracranial tumor that arises from arachnoid cells. It is reported to be the most common primary brain tumor (39%). Meningioma is diagnosed based on clinical and radiological findings, but a definitive diagnosis requires histopathology examination. However, the clinical, radiological, and histopathological profile of meningioma is rarely studied in Indonesia. Objective: This study aimed to identify the clinical, radiological, and histopathological profile of meningioma patients at Dr. Soetomo General Academic Hospital Surabaya from 2017 to 2021. Methods: This was a retrospective observational study with a cross-sectional design using secondary data collected from electronic medical records at Dr. Soetomo General Academic Hospital Surabaya in 2017-2021. Results: A total of 256 patients were included in this study. The majority of the patients in this study were female (83.98%), aged 40-49 years old (43.36%), and mostly had the clinical symptom of headache (35.94%). Meningiomas were mostly WHO grade I (85.16%), with a transitional subtype (44.92). Based on the Kruskal-Wallis test, there were differences in histopathological grading between male and female patients (p = 0.000), as well as between homogenous and heterogenous tumor enhancement (p = 0.027). However, there were no differences in histopathological grading between the dural tail findings (p = 0.181) and hyperostosis findings (p = 0.135). Conclusion: Meningioma was found to be more common in females than in males, with the peak occurring in 40-49 years old. The most prevalent clinical symptom was headache, and convexity was the most common location for these tumors, most of which were larger than 3 cm. The majority of meningiomas were WHO grade I with transitional subtype.   
Profile of Stroke Patients in John Piet Wanane General Hospital Sorong: A Descriptive Study Ardiansyah, Djohan; Ruma, Agustinus; Luhur, Lu Jordy
AKSONA Vol. 5 No. 2 (2025): JULY 2025
Publisher : Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/aksona.v5i2.56139

Abstract

Highlight: Hypertension is the leading risk factor for cardiovascular disease and stroke. Blood pressure variability, including early morning surge, increases stroke risk. Low education is associated with an increased risk of stroke due to limited health literact and lifestyle challenges.   ABSTRACT Introduction: Stroke has become the major cause of physical disability in adults and the second leading cause of death in middle- to high-income countries. Indonesia has the second-highest mortality rate and stroke burden in Southeast Asia. Furthermore, there is limited study on stroke in eastern Indonesia, especially in Papua. Objective: This study aimed to evaluate the clinical profile of stroke patients treated in John Piet Wanane General Hospital. Methods: This descriptive, hospital-based study was conducted at John Piet Wanane General Hospital, Sorong, Southwest Papua, from August 1, 2023, to January 31, 2024. Data were collected  through interviews and the identification of  subjects’ medical records based on inclusion and exclusion criteria. Results: This study involved a total of 143 patients, with an average age of 58.17 ± 10.516 years. The gender distribution was nearly equal, with 52.4% women and 47.6% men. The subjects mainly had an overweight Body Mass Index (BMI) (39,2%) or a normal BMI (36.4%). Obesity and underweight were the least common with percentage of 18.9%% and 5.6% of subjects, respectively. Hypertension (75.5%), prior stroke (33.6%), and hyperlipidemia (33.6%) were the most frequently found among subjects. Diabetes mellitus was found in 29.4% of subects, followed by smoking (28.7%), a history of heart disease (21%), and alcohol consumption (14.7%).  Ischemic stroke was the most prevalent type of stroke (65.7%), followed by intracerebral hemorrhage (23,8%), transient ishcemic attack (TIA) (5.6%), subarachnoid hemorrhage (2.8%), and pontine hemorrhage (2.1%). Conclusion:This study revealed that ischemic stroke was the predominant subtype, while pontine hemorrhage was rare. Hypertension emerged as the most common risk factor, followed by prior stroke, hyperlipidemia, and diabetes mellitus, highlighting the substantial burden of modifiable vascular risk factors.  
Co-Authors Duta Angela Joni Susanto, Joni Luhur, Lu Jordy Ruma, Agustinus Sri Andreani Utomo, Sri Andreani Suprabawati, Desak Gede Agung Valeryna, Natasha Vita Kusuma Rahmawati