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Compartmental Modeling Approach: Application on Transdermal Delivery for In Vitro Drug Permeation Mechanism Analysis Pawestri, Sekar Ayu; Nugroho, Akhmad Kharis; Lukitaningsih, Endang; Purwantiningsih
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2198

Compartmental modeling analysis was used to understand the transport mechanism of drugs in biological systems by computation presented as intercompartmental flows or material. This study was aimed to implement compartmental modeling analysis for in vitro permeation studies in transdermal delivery. The cumulative drug transported versus time were obtained based on the previous report and implemented the two structural different proposed models. WinSAAM software (Windows-based Simulation Analysis and Modeling-WinSAAM Project Group, University of Pennsylvania) was used to analyze data with compartmental analysis. The chosen models were selected through visual and numeric evaluation. The best model had been chosen and could figure out the drug transport kinetics in the biological system. The compartmental modeling approach was helpful used in understanding drug transport mechanisms in transdermal delivery and effectively estimate the drug transport parameter.

Synthesis and Antibacterial Properties of Fluorapatite and FAp-ZnO-Chitosan Composite as Dental Implant Materials Charlena; Khofiyatuzziyadah, Alif Aryan; Akhiruddin; Purwantiningsih
Science and Technology Indonesia Vol. 10 No. 2 (2025): April
Publisher : Research Center of Inorganic Materials and Coordination Complexes, FMIPA Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.26554/sti.2025.10.2.562-573

Regenerative biomaterials research has continued to grow in recent decades, one of which is dental implants. The material that can be used is fluorapatite (FAp), as it is a significant element of human bones and teeth. FAp has better chemical and thermal stability than other apatite materials. However, FAp has low antibacterial properties, so it needs to be composited with other antibacterial materials, such as zinc oxide (ZnO) and chitosan. In addition, chitosan was also added to stabilize FAp and ZnO an effort to increase antibacterial and in vitro bioactivity in apatite formation. Therefore, this research intends to synthesize and assess the antibacterial properties and in vitro bioactivity of FAp-ZnO chitosan to increase its potential as a dental implant manufacturing material. FAp and ZnO were synthesized and then composited with chitosan into FAp-ZnO-chitosan by a simple mixing method. The FAp-ZnO-chitosan composite was successfully synthesized by looking at X-ray diffraction (XRD), Fourier Transform Infra-Red (FTIR), and Scanning Electron Microscope-Energy Dispersive X-ray (SEM EDX) characterization results. The in vitro bioactivity of the composite showed new surface growth during immersion with simulated body fluid (SBF) solution, indicating potential attachment of the implant material to the tissue. The antibacterial properties of FAp-ZnO-chitosan also showed an increased zone of inhibition compared to the single material. This indicates that the FAp-ZnO-chitosan composite material has the potential to be used as a dental implant material.

Aktivitas insektisida ekstrak Piper aduncum dan Aglaia odorata terhadap Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae): Insecticidal activity of Piper aduncum and Aglaia odorata extracts on Plutella xylostella (Linnaeus) (Lepidoptera: Plutellidae) heviyanti, Maria; Dadang; Sartiami, Dewi; Kusumah, Yayi Munara; Purwantiningsih
Jurnal Entomologi Indonesia Vol 22 No 1 (2025): March
Publisher : Perhimpunan Entomologi Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.5994/jei.22.1.52

One of the main problems in the cultivation of Brassicaceae vegetable plants is the attack of diamondback moth Plutella xylostella (Linnaeus). Extracts of Piper aduncum and Aglaia odorata have the potential to be used as botanical insecticides because they contain compounds that are toxic to insects. This study aims to evaluate the toxicity and feeding inhibition activity of hexane-extract of P. aduncum fruits and methanol-extract of A. odorata twigs against second instar larvae of diamondback moth. Extraction was carried out using the maceration method with a powder-to-solvent ratio of 1:10 (w/v). The diamondback moth insects used were from colonies reared in the laboratory. The lethal effect test was conducted using the leaf-dip method with test concentrations equivalent to LC15, LC35, LC55, LC75, LC95, and a control. The feeding inhibition test was conducted using the choice-test method with test concentrations equivalent to LC15, LC35, LC55, and a control. The results show that the hexane-extract of P. aduncum fruit is more toxic to second instar P. xylostella larvae than the methanol-extract of A. odorata twigs based on the probit analysis value of the relationship between concentration and mortality. The LC50 and LC95 values of P. aduncum extract were 0.07% and 0.14%, respectively, while the LC50 and LC95 values of A. odorata extract were 1.63% and 4.72%. Additionally, P. aduncum and A. odorata extracts also exhibited feeding against diamondback moth at concentrations of 0.07% and 1.77%, respectively. The combined effects of direct toxicity and feeding inhibition contributed to the mortality of the test insects. Thus, these two extracts, escpecially P. aduncum extract wich demonstrated higher effectiveness, have a great potential as botanical insecticides for controlling diamondback moth in Indonesia.

Compartmental Modeling Approach: Application on Transdermal Delivery for In Vitro Drug Permeation Mechanism Analysis Pawestri, Sekar Ayu; Nugroho, Akhmad Kharis; Lukitaningsih, Endang; Purwantiningsih
Journal of Food and Pharmaceutical Sciences Vol 9, No 3 (2021): J.Food.Pharm.Sci
Publisher : Integrated Research and Testing Laboratory (LPPT) Universitas Gadjah Mada

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.22146/jfps.2198

Compartmental modeling analysis was used to understand the transport mechanism of drugs in biological systems by computation presented as intercompartmental flows or material. This study was aimed to implement compartmental modeling analysis for in vitro permeation studies in transdermal delivery. The cumulative drug transported versus time were obtained based on the previous report and implemented the two structural different proposed models. WinSAAM software (Windows-based Simulation Analysis and Modeling-WinSAAM Project Group, University of Pennsylvania) was used to analyze data with compartmental analysis. The chosen models were selected through visual and numeric evaluation. The best model had been chosen and could figure out the drug transport kinetics in the biological system. The compartmental modeling approach was helpful used in understanding drug transport mechanisms in transdermal delivery and effectively estimate the drug transport parameter.

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