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All Journal Journal Of Widya Medika Junior INDONESIAN JOURNAL OF MEDICAL LABORATORY SCIENCE AND TECHNOLOGY
Willianto, Vincentius Michael
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Health Professions Medicine & Pharmacology Public Health Social Sciences

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Effect Of Vetiver Essential Oil In 10% And 30% Concentration To The Cortisol Hormones Of Stressor-Induced Rats Willianto, Vincentius Michael; Suyono, Handi; Jong, F.X Himawan H.
JOURNAL OF WIDYA MEDIKA JUNIOR Vol 2, No 4 (2020): October
Publisher : FAKULTAS KEDOKTERAN UNIVERSITAS KATOLIK WIDYA MANDALA SURABAYA

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33508/jwmj.v2i4.2739

Abstract

Background: The number of people with mental health problems is still high in the world, especially depression. This incident is triggered by the stress of each individual on anongoing basis and failure to adapt. Stress regulation is a preventive measure to preventdepression in individuals. Currently, there are many developing uses of essential oils as antistress relaxation therapy. Vetiver essential oil is believed to reduce stress levels. Purpose: This study aimed to determine the effect of using vetiver essential oil with different concentrations and administration periods on changes in cortisol levels. Methods: This study used Rattus norvegicus experimental animals with the Forced Swim Test (FST) as a stressor. Vetiver essential oil concentrations of 10% and 30% were administered with the essential oil preparation given after giving stressor. Stress level in experimental animals was measured from the hormone cortisol in the blood. The method of measuring cortisol in experimental animals was carried out using the Enzyme-Linked Immuno Sorbent Assay (ELISA) method. Results: This study obtained significant results from the Kruskal Wallis statistical test ondecreasing cortisol levels in experimental animals by administering vetiver essential oil with10% concentration. Changes in the cortisol hormone in experimental animals and cortisollevels were not affected by the length of time of administration.
STAT3, but not Ki-67, expression is independently associated with tumor progression in colorectal carcinoma: A comparative immunohistochemical biomarker analysis Wedharga, I Gede Putu Adhi; Willianto, Vincentius Michael; Theodora, Imelda; Parengkuan, Irene; Novita, Bernadette Dian
JURNAL INDONESIA DARI ILMU LABORATORIUM MEDIS DAN TEKNOLOGI Vol 7 No 2 (2025): From Natural Compounds to Disease Mechanisms: An Integrated Research Outlook
Publisher : Universitas Nahdlatul Ulama Surabaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/ijmlst.v7i2.7711

Abstract

The insidious progression of colorectal carcinoma (CRC) at early stages often hampers timely screening and diagnosis, resulting in delayed intervention and poor clinical outcomes. Ki-67 and Signal Transducer and Activator of Transcription 3 (STAT3) have been widely studied for their roles in tumor proliferation and survival. However, comparative studies assessing their clinicopathological relevance in CRC progression remain limited, and their relative contributions to tumor aggressiveness are unclear. This study aimed to evaluate the clinicopathological significance and association of Ki-67 and STAT3 expression with tumor aggressiveness, focusing on their roles in tumor infiltration and size as indicators of CRC progression. Thirty-eight formalin-fixed, paraffin-embedded (FFPE) CRC tissue specimens were collected from patients undergoing surgical resection for this cross-sectional study. Ki-67 and STAT3 expression were assessed using immunohistochemical (IHC) staining. Clinicopathological data were retrieved from medical records. Protein expression was quantified using inverted mean gray values via digital image analysis. Ki-67 and STAT3 expression levels significantly correlated with tumor infiltration (Ki-67: r = 0.322, p = 0.049; STAT3: r = 0.429, p = 0.007) and size (Ki-67: r = 0.425, p = 0.008; STAT3: r = 0.452, p = 0.004). No significant correlation was found between Ki-67 and STAT3 (r = 0.225, p = 0.175). Only STAT3 was independently associated with infiltration (OR per 1-standard deviation: 4.11, p = 0.043) and size (OR per 1-SD: 3.41, p = 0.047). While both markers are associated with CRC progression, only STAT3 shows an independent association with tumor aggressiveness, underscoring its role beyond cell proliferation and suggesting broader involvement in tumor invasion and progression pathways.
Co-Authors Handi Suyono Jong, F.X Himawan H. Novita, Bernadette Dian Parengkuan, Irene Theodora, Imelda Wedharga, I Gede Putu Adhi