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CRISPR-Cas9 Potential in Eradicating HIV Latent Reservoir as The Up-to-date Therapy For HIV-1 Salim, Jesica Putri; Anggraini, Friska; Safa Nabila Putri; Maritska, Ziske
Sriwijaya Journal of Medicine Vol. 4 No. 1 (2021): Sriwijaya Journal of Medicine
Publisher : Fakultas Kedokteran Universitas Sriwijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32539/sjm.v4i1.206

Abstract

According to the Ministry of Health in Indonesia, in 2018, there are about 640 thousand cases of people with HIV within the death rate of 38 thousand people. This number grows annually, in fact, according to WHO, there are approximately 38 million people who are diagnosed with HIV in the world in 2019. Thus, HIV-AIDS is a dangerous health problem and needs to be taken care of as soon as possible. HIV (Human Immunodeficiency Virus) is a retrovirus that got its name from the infecting immune cells in the human body. There are two types of HIV, named HIV-1 and HIV-2. Both have the same basic gene arrangement, transmission process, intracellular replication lane, and both cause AIDS. The differences between them are the HIV-1 spreads globally, while HIV-2 locally happens in West Africa. Currently, ART (Antiretroviral Therapy) is the most commonly used method of treatment for HIV-1. Treatment for HIV-1 with ART is effective in controlling HIV-1 virus replication but has not been able to completely eradicate the latent viral reservoir. In the past few years, it is known that there is a CRISPR (Clustered Regularly Interspaced Short Palindromic Repeat) method that can modify genes (DNA) in the body of an organism. However, apart from its potential in handling HIV-1, there are still obstacles in the mechanism.
Musaqat Dan Muzara’ah Luthfi, Ahmad; Anggraini, Friska
Al-Mizan: Jurnal Ekonomi Syariah Vol 6 No I (2023): Al-Mizan: Jurnal Ekonomi Syariah
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat IAI An-Nadwah Kuala Tungkal

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54459/almizan.v6iI.499

Abstract

Jurnal ini bertujuan untuk menjelaskan bagaimana aqad Muzara’ah dan Musaqah, Kerjasama di bidang pertanian sebenarnya sudah ada sejak dulu hingga sekarang. Namun yang terjadi sekarang kerjasama antara mereka (pemilik tanah dan penggarap) biasa disebut paroan sawah, dimana kontraknya tidak tertulis tetapi hanya secara lisan. Hal ini sering menimbulkan kerugian di satu sisi, karena tidak ada bukti. Dalam perbankan syariah, prinsip yang paling banyak digunakan adalah musyawarah dan mudharabah, sedangkan muzara’ah dan digunakan khusus untuk pembiayaan perkebunan atau pertanian oleh beberapa bank syariah. Muzara’ah memilikinya dari hanya lewat, Italia’ah terbatas pada tanaman yang seperti, beras, jahe, kentang. Sedangkan untuk tanaman semusim skema musaqat dapat digunakan. Karena sifat muzara’ah yang spesifik ini, kebanyakan bank syariah menggunakan musyawarah atau salam untuk kredit usaha pertanian. Namun dalam perkembangannya, praktik muzara’ah cenderung pada mudharabah (kerja sama dengan sistem bagi hasil). Secara teknis mudharabah adalah akad kerjasama bisnis antara dua pihak dimana pihak pertama (shahib al maal) menyediakan seluruh modal, sedangkan pihak lainnya disebut mudharib sebagai pengelola usaha. Keuntungan dalam mudharabah akan dibagi berdasarkan kesepakatan yang dituangkan dalam akad. Sedangkan kerugian akan ditanggung oleh pihak yang melakukan kelalaian.
Synthesis and Characterization of Natural Pahae Zeolite–Durian Peel Activated Carbon as an Adsorbent for Phosphate Reduction in Laundry Wastewater Susilawati; Fadhilah, Siti; Anggraini, Friska
Journal of Technomaterial Physics Vol. 7 No. 2 (2025): Journal of Technomaterial Physics
Publisher : Talenta Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32734/jotp.v7i2.22735

Abstract

This study aims to synthesize and characterize composites based on Pahae Natural Zeolite and Durian Peel Activated Carbon as phosphate reducers in laundry wastewater. Zeolite was activated using 1 M NaCl solution, while activated carbon was prepared by carbonization at 500 °C for 2 hours. The Zeolite–Activated Carbon mixtures were prepared with compositions of 100%:0%, 95%:5%, 90%:10%, 85%:15%, 80%:20%, 75%:25%, and 0%:100%, pressed at 6 tons for 10 minutes, and sintered at 700 °C, 800 °C, and 900 °C for 4 hours. Characterization included physical properties (porosity, water absorption), mechanical properties (hardness), morphology (SEM), crystal structure (XRD), and elemental composition (XRF). The results showed that the optimum condition was achieved at a 75%:25% composition and 700 °C, with porosity of 59.67%, water absorption of 56.06%, and phosphate reduction efficiency of 80.86%. The highest hardness value was obtained at 100%:0% composition at 900 °C, reaching 784.14 MPa. Therefore, the Pahae Natural Zeolite–Durian Peel Activated Carbon composite demonstrates potential as an effective and environmentally friendly adsorbent for wastewater treatment.