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All Journal Berkala Ilmu Kesehatan Kulit dan Kelamin Biomedical Journal of Indonesia Bioscientia Medicina : Journal of Biomedicine and Translational Research Sumatera Medical Journal Bioscientia Medicina : Journal of Biomedicine and Translational Research Jurnal Ilmu Kesehatan Indonesia (JIKSI)
Raveinal
Unknown Affiliation
Biochemistry, Genetics & Molecular Biology Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Effectiveness of Drug Allergy Management: A Meta-Analysis Saputra Poedjijo, Yanuar Surya; Raveinal; Dwitya Elvira
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 11 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i11.1115

Abstract

Background: Drug allergies pose a significant challenge in clinical practice, impacting patient safety and treatment options. This meta-analysis aims to evaluate the effectiveness of various drug allergy management strategies, including desensitization, graded challenges, and alternative medications. Methods: A systematic search of electronic databases (PubMed, Embase, Cochrane Library) was conducted from 2018 to 2024. Randomized controlled trials (RCTs) and observational studies assessing drug allergy management interventions were included. The primary outcome was the successful administration of the culprit drug without allergic reactions. Secondary outcomes included adverse events and quality of life. Data were extracted and pooled using random-effects models. Results: A total of 32 studies (15 RCTs, 17 observational studies) encompassing 4,215 patients were included. Desensitization protocols demonstrated a high success rate (89%) in enabling the administration of culprit drugs. Graded challenges also showed promising results (75% success rate). The use of alternative medications was associated with a lower risk of allergic reactions but may compromise treatment efficacy in some cases. Conclusion: This meta-analysis highlights the effectiveness of drug allergy management strategies, particularly desensitization and graded challenges. These interventions offer promising avenues to overcome drug allergies and optimize patient care. Further research is needed to explore long-term outcomes and refine management protocols.
Perbedaan Rerata Kadar Albumin Pasien Lupus Eritematosus Sistemik berdasarkan Derajat Aktivitas Penyakit di RSUP Dr. M. Djamil Padang Ulti, Zifa Amanda; Elvira, Dwitya; Firdawati; Efrida; Raveinal; Aliska, Gestina
Jurnal Ilmu Kesehatan Indonesia Vol. 6 No. 4 (2025): Desember 2025
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v6i4.1478

Abstract

Latar Belakang: Lupus Eritematosus Sistemik (LES) adalah penyakit autoimun kompleks yang dapat menyerang berbagai pertahanan sistem tubuh. Penyakit ini berhubungan dengan pembentukkan autoantibodi sehingga dapat menyebabkan inflamasi kronis yang berujung pada kerusakkan jaringan tubuh. Aktivitas Penyakit LES diduga dapat mempengaruhi kadar albumin di dalam tubuh.    Objektif: Penelitian ini bertujuan untuk mengetahui apakah terdapat perbedaan rerata kadar albumin pasien LES berdasarkan derajat aktivitas penyakit di RS M. Djamil Padang. Metode: Penelitian ini menggunakan metode analitik dengan pendekatan cross-sectional study. Sampel penelitian berjumlah 59 pasien LES rawat jalan dan rawat inap di RS M. Djamil Padang yang dikumpulkan secara consecutive sampling. Analisis data penelitian menggunakan uji one way annova. Hasil: Pada penelitian ini didapatkan mayoritas pasien LES berada di rentang usia 26−35 tahun (44,1%), berjenis kelamin perempuan (100%). Lebih dari setengah pasien LES mengalami hipoalbuminemia (76,3%), sebagian besar pasien memiliki derajat aktivitas penyakit sedang (39%). Rerata kadar albumin terendah ditemukan pada pasien dengan derajat aktivitas penyakit berat sebesar 2,25 g/dL. Kesimpulan: Terdapat perbedaan yang bermakna pada rerata kadar albumin pasien LES. Rerata kadar albumin terendah pasien LES ada pada kelompok derajat aktivitas penyakit berat. Rerata kadar albumin tertinggi pasien LES ada pada kelompok derajat aktivitas penyakit ringan.
Co-Authors Arridho, Rijalun Dwitya Elvira, Dwitya Efrida Firdawati Gardenia Akhyar Gestina Aliska Gustin, Hanna Ida Rahmah Burhan Paishal Mizan Putra, Andikha Salwa Azzahra Saputra Poedjijo, Yanuar Surya Satya Wydya Yenny Ulti, Zifa Amanda