Article Per Year (5 Year)
p-Index From 2020 - 2025
0.562
P-Index
This Author published in this journals
All Journal Hang Tuah Medical Journal Eduvest - Journal of Universal Studies Jurnal Kedokteran Meditek
Pranitasari, Nita
Unknown Affiliation
Aerospace Engineering Biochemistry, Genetics & Molecular Biology Computer Science & IT Dentistry Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Nursing Public Health Social Sciences

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
The Effect of Golden Sea Cucumber Extract (Stichopus Hermanii) Administration on Serum Malondialdehyde (MDA) Levels In Wistar Strain White Rats (Rattus Norvegicus) Induced by Aspirin Anggraeni, Ajeng Hanum Arditha; Pranitasari, Nita; Kurnia, Wachjudi; Wijayaningrum, Lena
Eduvest - Journal of Universal Studies Vol. 5 No. 6 (2025): Eduvest - Journal of Universal Studies
Publisher : Green Publisher Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.59188/eduvest.v5i6.50239

Abstract

Drug-Induced Hepatitis (DIH) is a liver function disorder caused by the use of hepatotoxic drugs, which can affect liver metabolism acutely or chronically. A new paradigm suggests that natural-based treatments, such as sea cucumbers, have potential as therapy due to their superior antibacterial bioactivity. This study aims to evaluate the effect of golden sea cucumber extract (Stichopus hermanii) on serum malondialdehyde (MDA) levels in Wistar strain white rats (Rattus norvegicus) induced by aspirin. The study was conducted using a true experimental design with a post-test only control group and random sampling method, involving four treatment groups at the Hyperbaric and Biomolecular Laboratory of Hang Tuah University, Surabaya. The results showed that administering golden sea cucumber extract (Stichopus hermanii) at a dose of 972 mg/kg BW resulted in the highest serum MDA levels in Wistar strain white rats (Rattus norvegicus) induced by aspirin (p=0.001). The study concluded that the administration of golden sea cucumber extract (Stichopus hermanii) significantly affects serum MDA levels in Wistar strain white rats (Rattus norvegicus) induced by aspirin.
Karakteristik Determinan Preeklamsia di RSUD dr. Soedono Madiun periode 1 Januari 2020 sampai dengan 31 Desember 2020 HARIATI, FADILAMUNA; O. H. PRASETYADI, FRANS; PRANITASARI, NITA; EDY SUDIARTA, KETUT
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.317

Abstract

Abstract Background : Preeclampsia become one of the cases that causes maternal and perinatal morbidity and mortality. Morbidity and mortality occurs due to disorders in pregnancy (preeclampsia and eclampsia) by 14%. Preeclampsia is gestational hypertension characterized with increased blood pressure(2140/90mmHg), proteinuria(>300mg/24 hours), increased creatinine(>1.02mg/dL), and edema that can occur with age gestation >20 weeks. The purpose of this study is to determine the determinants which can cause preeclampsia in RSUD dr. Soedono Madiun, From January 1st2020 to December 31st2020. Methods : This type of research is descriptive research using a documentation study of patient medical record sheets at RSUD dr. Soedono Madiun from January 1st2020 to December 31st2020. The techniques sampling in this study is a purposive sampling technique. Univariate analysis is used to describe the characteristics of the variables that have been studied. Results : The case of preeclampsia in RSUD dr. Soedono as many as 67 cases. Most occurred in multigravida as many as 39cases (58.2%), at maternal age 20-35 as many as 48cases (71.6%), with the highest body mass index were obese or BMI more equal to 30 as many as 33cases (49.3%), hypertension as the most happened of maternal disease with 9cases (13.43%) and pregnancy disorders in 18cases (26.87%) with a long gestation interval. Conclusion : Preeclampsia is more common in multigravida pregnancies (2-4 weeks) at the age of the mother are 20-35 years with BMI more than 30 or obesity and mothers who have hypertension and long gestation interval. Keywords : Preeclampsia, Determinants
Pengaruh ekstrak ikan patin pada aktivitas katalase dan kadar MDA serum tikus yang diinduksi aloksan Handajani, Fitri; Nabil; Pranitasari, Nita
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3201

Abstract

Introduction: Pangasius fish is known to contain antioxidants. Catalase is an enzymatic antioxidant whose role is to reduce oxidative stress. Oxidative stress results in fat oxidation which can be checked by Malondialdehyde (MDA) levels. Alloxan induction will cause oxidative stress. Purpose: This study aims to decide the role of Pangasius extract on catalase and MDA activity in alloxan-induced experimental animals. 24 hundred Rattus norvegicus were isolated into K0 the group without treatment, K1 was the group induced by an intraperitoneal (i.p) alloxan dose of 150 mg/kgBB on the 7th day, K2 was the group that was induced by an alloxan dose of 150 mg/kgBB i.p on the 7th day and given Pangasius fish oil extricate dosage of 73 mg/kgBB on the 10th day intragastric every day to 14 days. Results: The data investigation showed that there were significant differences in pancreatic catalase activity between groups K0 and K1 (p=0.001) and between groups K1 and K2 (p=0.001). These conditions indicate that Pangasius extract can scavenge free radicals so that there is no decrease in catalase activity in the pancreas. Pancreatic MDA levels showed significant results between groups K0 and K1 (p=0.010) and between groups K1 and K2 (p=0.010). This is due to the ability of the antioxidants contained in Pangasius fish extract to reduce free radicals thereby reducing oxidative stress resulting in decreased lipid peroxidation. Conclusion: the administration of Pangasius extract 73 mg/kgBW can decrease free radicals formed due to alloxan induction so that it can increase catalase activity and reduce pancreatic MDA
Co-Authors Anggraeni, Ajeng Hanum Arditha EDY SUDIARTA, KETUT Handajani, Fitri HARIATI, FADILAMUNA Kurnia, Wachjudi Nabil O. H. PRASETYADI, FRANS Wijayaningrum, Lena