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Pranitasari, Nita
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Karakteristik Determinan Preeklamsia di RSUD dr. Soedono Madiun periode 1 Januari 2020 sampai dengan 31 Desember 2020 HARIATI, FADILAMUNA; O. H. PRASETYADI, FRANS; PRANITASARI, NITA; EDY SUDIARTA, KETUT
Hang Tuah Medical Journal Vol 22 No 2 (2025): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v22i2.317

Abstract

Abstract Background : Preeclampsia become one of the cases that causes maternal and perinatal morbidity and mortality. Morbidity and mortality occurs due to disorders in pregnancy (preeclampsia and eclampsia) by 14%. Preeclampsia is gestational hypertension characterized with increased blood pressure(2140/90mmHg), proteinuria(>300mg/24 hours), increased creatinine(>1.02mg/dL), and edema that can occur with age gestation >20 weeks. The purpose of this study is to determine the determinants which can cause preeclampsia in RSUD dr. Soedono Madiun, From January 1st2020 to December 31st2020. Methods : This type of research is descriptive research using a documentation study of patient medical record sheets at RSUD dr. Soedono Madiun from January 1st2020 to December 31st2020. The techniques sampling in this study is a purposive sampling technique. Univariate analysis is used to describe the characteristics of the variables that have been studied. Results : The case of preeclampsia in RSUD dr. Soedono as many as 67 cases. Most occurred in multigravida as many as 39cases (58.2%), at maternal age 20-35 as many as 48cases (71.6%), with the highest body mass index were obese or BMI more equal to 30 as many as 33cases (49.3%), hypertension as the most happened of maternal disease with 9cases (13.43%) and pregnancy disorders in 18cases (26.87%) with a long gestation interval. Conclusion : Preeclampsia is more common in multigravida pregnancies (2-4 weeks) at the age of the mother are 20-35 years with BMI more than 30 or obesity and mothers who have hypertension and long gestation interval. Keywords : Preeclampsia, Determinants
Pengaruh ekstrak ikan patin pada aktivitas katalase dan kadar MDA serum tikus yang diinduksi aloksan Handajani, Fitri; Nabil; Pranitasari, Nita
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3201

Abstract

Introduction: Pangasius fish is known to contain antioxidants. Catalase is an enzymatic antioxidant whose role is to reduce oxidative stress. Oxidative stress results in fat oxidation which can be checked by Malondialdehyde (MDA) levels. Alloxan induction will cause oxidative stress. Purpose: This study aims to decide the role of Pangasius extract on catalase and MDA activity in alloxan-induced experimental animals. 24 hundred Rattus norvegicus were isolated into K0 the group without treatment, K1 was the group induced by an intraperitoneal (i.p) alloxan dose of 150 mg/kgBB on the 7th day, K2 was the group that was induced by an alloxan dose of 150 mg/kgBB i.p on the 7th day and given Pangasius fish oil extricate dosage of 73 mg/kgBB on the 10th day intragastric every day to 14 days. Results: The data investigation showed that there were significant differences in pancreatic catalase activity between groups K0 and K1 (p=0.001) and between groups K1 and K2 (p=0.001). These conditions indicate that Pangasius extract can scavenge free radicals so that there is no decrease in catalase activity in the pancreas. Pancreatic MDA levels showed significant results between groups K0 and K1 (p=0.010) and between groups K1 and K2 (p=0.010). This is due to the ability of the antioxidants contained in Pangasius fish extract to reduce free radicals thereby reducing oxidative stress resulting in decreased lipid peroxidation. Conclusion: the administration of Pangasius extract 73 mg/kgBW can decrease free radicals formed due to alloxan induction so that it can increase catalase activity and reduce pancreatic MDA
Co-Authors EDY SUDIARTA, KETUT Handajani, Fitri HARIATI, FADILAMUNA Nabil O. H. PRASETYADI, FRANS