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HUBUNGAN ANTARA AKTIVITAS BELAJAR KELOMPOK DENGAN INDEKS PRESTASI MAHASISWA SEMESTER 6 FAKULTAS KEDOKTERAN UNIVERSITAS HANG TUAH SURABAYA TAHUN AJARAN 2017/2018 Handajani, Fitri; Hapsari, Kinanti; Garianto, Efyluk
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1070

One of the active learning methods is to do a study group. Researcher is interested in research on the correlation between study group activities and student?s grade, so that students can find learning methods which may influence academic outcomes and facilitate learning, especially the medical students. This observational analytic study was carried out with a cross sectional design. The data of this study were obtained from the answers to the respondent's questionnaire in the Medical Faculty of Hang Tuah University, Surabaya. The sample in this study were semester 6 students of the 2017/2018 academic year at the Faculty of Medicine, University of Hang Tuah Surabaya (130 respondents). Based on the Spearman correlation statistical test between study group activities with the 6th semester students grade point, the significance of the correlation between study group activities and the 6th semester students grade point is 0.687. With a value of ? = 0.05, means p> ?, it can be concluded that the correlation between the two variables is not significant so that H0 accepts and H1 is rejected. So, there is no correlation between study group activities with 6th semester grade point. There is no correlation between study group activities and the 6th semester students grade point in the Faculty of Medicine, Hang Tuah University Surabaya.

Efek Pemberian Eucheuma spinosum sebagai Profilaksis dalam Penghambatan Peningkatan SGPT pada Tikus yang Diinduksi Dexamethasone HANDAJANI, FITRI; PERMANA, I GEDE PUTU BAYU TIRTA; TARUNA, DODY; UNTARI, NI KOMANG SRI DEWI
Hang Tuah Medical Journal Vol 21 No 1 (2023): Hang Tuah Medical Journal
Publisher : Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/htmj.v21i1.359

Serum Glutamic Pyruvate Transaminase (SGPT) is a specific biomarker for detecting liver disease. This study aimed to determine the effect of giving 200 mg/Kg BW of Euchema spinosum extract as a prophylaxis against increasing SGPT in Rattus norvegicus rats injected with dexamethasone 8mg/Kg BW for six days. This experimental study with a randomized posttest-only control group design using 24 white male rats which were divided into three groups; group 1 was the untreated group, group 2 was given dexamethasone 8 mg/Kg BW for six days, the group 3 was given prophylactic 200 mg/Kg BW Eucheuma sp. extract for 13 days. After the treatment period, the group was terminated, and SGPT levels were measured using Cobas Integra. SGPT levels were then analyzed using SPSS. The normality test results for SGPT levels obtained a value of p> 0.05, and this value was only obtained from group 1 (p = 0.085) and group 2 (p = 0.224), while the group 3 showed that the distribution of data was not normally distributed (p = 0.022). The Kruskal-Wallis test showed a mean difference in SGPT levels between groups. The Mann-Whitney U test obtained a lower SGPT score in group 3 than in group 2 (p=0.007). Group 1, compared to group 3, decreased (p=0.001). Giving extract of Eucheuma sp. at a dose of 200 mg/Kg BW can inhibit the increase in SGPT levels in dexamethasone-induced white male rats (Rattus norvegicus).

PENGARUH EKSTRAK BUAH MENGKUDU (MORINDA CITRIFOLIA) TERHADAP KADAR KOLESTEROL TOTAL DARAH PADA TIKUS PUTIH (RATTUS NORVEGICUS) JANTANGALUR WISTARYANG DIBERI DIET TINGGI LEMAK Priadna, Astrid Ika; Adiwinoto, Budiarto; Handajani, Fitri
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 1 (2019): FEBRUARY
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i1.922

Background: High cholesterol dietinduced hypercholesterolemia. Noni fruit extracthas flavonoids which are expected to reduceblood total cholesterol levels.This study aims to determine the effect of noni fruit extract (Morinda citrifolia) on total blood cholesterol levels in wistar strain male rats (Rattus norvegicus) given a high-fat diet. Method: Experimental study using post test only control group design. A total of 24 wistar strain male rats were divided into 3 groups: negative controlgroup given standard feed; positive control group of experimental animals who were given a high-fat diet; the experimental group treated with a high-fat diet for 14 days and given noni fruit extractat a dose of 200 mg / Kg BB. On the 29th day total blood cholesterol levels were measured for all groups of experimental animals. Results: The Mann Whitney UTest showed a significant increase in total blood cholesterol levels in the positive group of experimental animals given a high-fat diet (68.13 mg/dl) compared to the negative control group of experimental animals given standard feed (51.25 mg/dl). There was a significant decrease in total blood cholesterol levels in the experimental group treated with a high-fat diet and noni fruit extract (61mg/dl) compared to the average positive control group of experimental animals given a high-fat diet (68.13 mg/dl). Conclusion: Provision of a high-fat diet in wistar strain male ratscan significantly increase total blood cholesterol levels. The administration of noni fruit extract in wistar strain male ratscan significantly reduce total blood cholesterol levels

HUBUNGAN ANTARA AKTIVITAS BELAJAR KELOMPOK DENGAN INDEKS PRESTASI MAHASISWA SEMESTER 6 FAKULTAS KEDOKTERAN UNIVERSITAS HANG TUAH SURABAYA TAHUN AJARAN 2017/2018 Handajani, Fitri; Hapsari, Kinanti; Garianto, Efyluk
Jurnal Ilmu Kesehatan dan Kesehatan Vol 3 No 2 (2019): AUGUST
Publisher : UNUSA Press

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.33086/mhsj.v3i2.1070

One of the active learning methods is to do a study group. Researcher is interested in research on the correlation between study group activities and student’s grade, so that students can find learning methods which may influence academic outcomes and facilitate learning, especially the medical students. This observational analytic study was carried out with a cross sectional design. The data of this study were obtained from the answers to the respondent's questionnaire in the Medical Faculty of Hang Tuah University, Surabaya. The sample in this study were semester 6 students of the 2017/2018 academic year at the Faculty of Medicine, University of Hang Tuah Surabaya (130 respondents). Based on the Spearman correlation statistical test between study group activities with the 6th semester students grade point, the significance of the correlation between study group activities and the 6th semester students grade point is 0.687. With a value of α = 0.05, means p> α, it can be concluded that the correlation between the two variables is not significant so that H0 accepts and H1 is rejected. So, there is no correlation between study group activities with 6th semester grade point. There is no correlation between study group activities and the 6th semester students grade point in the Faculty of Medicine, Hang Tuah University Surabaya.

The Correlation between Visual, Auditory, and Kinesthetic Learning Styles with SOOCA Examination Scores in Students of the Faculty of Medicine, Hang Tuah University, Surabaya Vijaya, Ailya Tefanya; Wibowo, Prajogo; Mutiadesi, Wahyu Prasasti; Handajani, Fitri
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 3 No. 3 (2023): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v3i3.116

Learning style is one way that someone chooses to understand the material more quickly and easily. Everyone needs to identify their learning style in order to determine the most efficient learning method according to their characteristics. There are three kinds of learning styles, namely visual, auditory, and kinesthetic learning styles. Every student has a basis for this learning style, but not all of them develop proportionally, but some become dominant. This research was conducted to determine the relationship between the three learning styles and sooca exam scores in students of the Faculty of Medicine, Hang Tuah University, Surabaya. This research uses quantitative methods. The population in this study were all pre-clinical students in semesters 2, 4, 6 with active student status at the Faculty of Medicine, Hang Tuah University, Surabaya who took the SOOCA (structure Objective Oral Examination) exam and were willing to fill out the questionnaire in the period of June to December 2022. The sample size was obtained in the time period is 86 respondents. The results showed that out of 86 respondents, 3 (3.5%) were 18 year old students, 10 (11.6%) were 19 year old students, 26 (30.2%) were 20 year old students, 39 (45.4%) ) students aged 21 years, 8 (9.3%) students aged 22 years. A total of 64 (74.4%) respondents were female, and 22 (25.6%) respondents were male. 13 (15.1%) respondents have a visual learning style, 13 (15.1%) respondents have an auditory learning style, and 60 (69.8%) respondents have a kinesthetic learning style. Conclusion of this study is that there is no relationship between Visual, Auditorial, and Kinesthetic Learning Styles with Sooca Examination Scores in students of the Faculty of Medicine, Hang Tuah University, Surabaya. The learning styles of the students of the Faculty of Medicine, Hang Tuah University, Surabaya, class of 2018, 2019 and 2020, mostly have a kinesthetic learning style.

Hubungan Hipertensi Terhadap Kematian Pasien Covid-19 Dengan Diabetes Melitus Tipe 2 di RSUP dr. Sardjito Fadhilah, Farah; Susanti, Vina Yanti; Nugroho, Dhite Bayu; Adhikara, Imam Manggalya; Handajani, Fitri
CoMPHI Journal: Community Medicine and Public Health of Indonesia Journal Vol. 4 No. 3 (2024): Februari
Publisher : Perhimpunan Dokter Kedokteran Komunitas dan Kesehatan Masyarakat Indonesia (PDK3MI)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37148/comphijournal.v4i3.199

Diabetes mellitus and hypertension are co-morbidities that are often found in COVID-19 patients. Diabetes can reduce the body's immunity and increase the rate of viral replication, and is associated with vascular problems. Hypertension is one of the comorbid diabetes with high morbidity and mortality. To determine the relationship between hypertension and the death of COVID-19 patients with type 2 diabetes mellitus at Dr Sardjito General Hospital. Observational study with a retrospective cohort study design, using COVID-19 registry data at Dr Sardjito General Hospital for the period March 2020-July 2021. COVID-19 patients with type 2 diabetes mellitus who had hypertension and those who did not have hypertension were selected at Dr Sardjito General Hospital and Collected data on mortality, age, sex, other comorbidities, severity and length of stay. Data were processed using SPSS, in univariate, bivariate, and multivariate analysis models. the results of multivariate analysis using logistic regression found that hypertension, age, and ischemic heart disease did not have a significant association with the death of COVID-19 patients with type 2 diabetes mellitus. The variable that had the greatest power as a predictor of death in COVID-19 patients with diabetes mellitus type 2 is ARDS with a risk of death 20.8 times higher than without ARDS. Patients with kidney failure are at risk of dying 2.7 times higher than those without kidney failure. The addition of length of stay (LOS) 1 day of treatment reduces the risk of death by 16.3%. Hypertension has no significant relationship as a predictor of death in COVID-19 patients with type 2 diabetes mellitus at Dr Sardjito General Hospital. Significant predictors of death in this study were ARDS, kidney failure, and were associated with length of stay (LOS).

Peran Profilaksis Ekstrak Rumput Laut (Eucheuma spinosum) Mencegah Kenaikan Kadar Gula Darah Tikus (Rattus norvegicus) yang Diinduksi Dexamethasone Kosala, Giselle; Handajani, Fitri; Nabil, Nabil; Samsuddin, Mohammad
Surabaya Biomedical Journal Vol 4 No 2 (2025): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i2.67

Hiperglikemia merupakan meningkatnya kadar glukosa darah melebihi normal. Eucheuma spinosum mengandung kadar antioksidan alami flavonoid yang kuat yang memiliki efek dapat meningkatkan kadar sensitivitas sel terhadap insulin dan meningkatkan produksi insulin sehingga dapat mencegah terjadinya hiperglikemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak rumput laut (Eucheuma spinosum) sebagai profilaksis dalam mencegah terjadinya kenaikan kadar gula darah yang diinduksi deksametason. Penelitian ini merupakan true experimental design with post test only control group design. Penelitian ini menggunakan 30 ekor tikus putih (Rattus norvegicus) jantan yang dibagi menjadi 3 kelompok; kelompok kontrol negatif (K(-)) tanpa perlakuan, kelompok kontrol positif (K(+)) kelompok yang diinduksi deksametason 8 mg/KgBB selama 6 hari, dan kelompok kontrol perlakuan (K(P)) yang diberikan profilaksis ekstrak rumput laut (Eucheuma spinosum) 200 mg/KgBB selama 14 hari dan diinduksi dengan deksametason selama 6 hari. Setelah masa perlakuan selesai dilakukan terminasi dan dilakukan perhitungan pada kadar glukosa darah yang diambil melalui aorta tikus. Hasil data secara statistic dianalisis menggunakan SPSS. Hasil penelitian kadar glukosa darah menggunakan uji one way ANOVA menunjukkan adanya perbedaan signifikan (p < 0,01). Uji post hoc Tukey menunjukkan adanya penurunan kadar glukosa darah yang bermakna pada kelompok kontrol perlakuan ketika dibandingkan dengan kelompok kontrol positif ( p < 0,01). Kesimpulan dari penelitian ini adalah pemberian profilaksis ekstrak rumput laut (Eucheuma spinosum) 200 mg/KgBB selama 14 hari dapat mencegah kenaikan gula darah yang bermakna dibandingkan dengan kelompok yang tidak diberikan profilaksis ekstrak rumput laut (Eucheuma spinosum). Kata kunci : Eucheuma spinosum, gula darah, flavonoid, deksametason

Peran Profilaksis Ekstrak Rumput Laut (Eucheuma spinosum) Mencegah Kenaikan Kadar Gula Darah Tikus (Rattus norvegicus) yang Diinduksi Dexamethasone Kosala, Giselle; Handajani, Fitri; Nabil, Nabil; Samsuddin, Mohammad
Surabaya Biomedical Journal Vol. 4 No. 2 (2025): Januari
Publisher : Fakultas Kedokteran, Universitas Hang Tuah

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30649/sbj.v4i2.67

Hiperglikemia merupakan meningkatnya kadar glukosa darah melebihi normal. Eucheuma spinosum mengandung kadar antioksidan alami flavonoid yang kuat yang memiliki efek dapat meningkatkan kadar sensitivitas sel terhadap insulin dan meningkatkan produksi insulin sehingga dapat mencegah terjadinya hiperglikemia. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak rumput laut (Eucheuma spinosum) sebagai profilaksis dalam mencegah terjadinya kenaikan kadar gula darah yang diinduksi deksametason. Penelitian ini merupakan true experimental design with post test only control group design. Penelitian ini menggunakan 30 ekor tikus putih (Rattus norvegicus) jantan yang dibagi menjadi 3 kelompok; kelompok kontrol negatif (K(-)) tanpa perlakuan, kelompok kontrol positif (K(+)) kelompok yang diinduksi deksametason 8 mg/KgBB selama 6 hari, dan kelompok kontrol perlakuan (K(P)) yang diberikan profilaksis ekstrak rumput laut (Eucheuma spinosum) 200 mg/KgBB selama 14 hari dan diinduksi dengan deksametason selama 6 hari. Setelah masa perlakuan selesai dilakukan terminasi dan dilakukan perhitungan pada kadar glukosa darah yang diambil melalui aorta tikus. Hasil data secara statistic dianalisis menggunakan SPSS. Hasil penelitian kadar glukosa darah menggunakan uji one way ANOVA menunjukkan adanya perbedaan signifikan (p < 0,01). Uji post hoc Tukey menunjukkan adanya penurunan kadar glukosa darah yang bermakna pada kelompok kontrol perlakuan ketika dibandingkan dengan kelompok kontrol positif ( p < 0,01). Kesimpulan dari penelitian ini adalah pemberian profilaksis ekstrak rumput laut (Eucheuma spinosum) 200 mg/KgBB selama 14 hari dapat mencegah kenaikan gula darah yang bermakna dibandingkan dengan kelompok yang tidak diberikan profilaksis ekstrak rumput laut (Eucheuma spinosum). Kata kunci : Eucheuma spinosum, gula darah, flavonoid, deksametason

Pengaruh ekstrak ikan patin pada aktivitas katalase dan kadar MDA serum tikus yang diinduksi aloksan Handajani, Fitri; Nabil; Pranitasari, Nita
Jurnal Kedokteran Meditek Vol 31 No 1 (2025): JANUARI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v31i1.3201

Introduction: Pangasius fish is known to contain antioxidants. Catalase is an enzymatic antioxidant whose role is to reduce oxidative stress. Oxidative stress results in fat oxidation which can be checked by Malondialdehyde (MDA) levels. Alloxan induction will cause oxidative stress. Purpose: This study aims to decide the role of Pangasius extract on catalase and MDA activity in alloxan-induced experimental animals. 24 hundred Rattus norvegicus were isolated into K0 the group without treatment, K1 was the group induced by an intraperitoneal (i.p) alloxan dose of 150 mg/kgBB on the 7th day, K2 was the group that was induced by an alloxan dose of 150 mg/kgBB i.p on the 7th day and given Pangasius fish oil extricate dosage of 73 mg/kgBB on the 10th day intragastric every day to 14 days. Results: The data investigation showed that there were significant differences in pancreatic catalase activity between groups K0 and K1 (p=0.001) and between groups K1 and K2 (p=0.001). These conditions indicate that Pangasius extract can scavenge free radicals so that there is no decrease in catalase activity in the pancreas. Pancreatic MDA levels showed significant results between groups K0 and K1 (p=0.010) and between groups K1 and K2 (p=0.010). This is due to the ability of the antioxidants contained in Pangasius fish extract to reduce free radicals thereby reducing oxidative stress resulting in decreased lipid peroxidation. Conclusion: the administration of Pangasius extract 73 mg/kgBW can decrease free radicals formed due to alloxan induction so that it can increase catalase activity and reduce pancreatic MDA

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