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Efektivitas Dan Keamanan Terapi dengan Rejimen Bedaquiline dalam Terapi Multidrug-Resistant Tuberculosis (TB-MDR): Kajian Sistematis Yana, I Gusti Agung Ari Kusuma
Pharmaceutical Journal of Indonesia Vol. 7 No. 2 (2022)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.pji.2022.007.02.8

Abstract

MDR-TB is a tuberculosis disease caused by Mycobacterium tuberculosis which is resistant to isoniazid and rifampin with or without resistance to other first-line drugs. The development of drug-resistant tuberculosis is causing worldwide concern. Globally in 2019, almost half a million TB sufferers of which 78% had MDR-TB. In recent years, MDR-TB patients increased by 10% from 186,883 patients in 2018 to 206,030 in 2019. Bedaquiline has been recommended by WHO guidelines. Studies related to the effectiveness and safety of Bedaquiline are still few so that there is a need for qualified information to prepare a country, especially Indonesia, for the use of Bedaquiline therapy, especially since Indonesia is ranked second out of two-thirds of the total global TB. Objective: to describe the effectiveness and safety of Bedaquiline in combination therapy for the treatment of MDR-TB. Methods: The literature search was carried out independently by researchers using the online databases of Science Direct, Pubmed, and Cochrane without restrictions on the type of research and year of publication. The keywords used in this study were combined with Boolean operators, namely “bedaquiline” AND “tuberculosis” AND “multi-drug resistant”. Results: Seven studies met the inclusion criteria, the intervention of giving Bedaquiline for 24 weeks can reduce the average time of culture conversion by about 60-85 days. The percentage of culture conversion rate was higher with Bedaquiline (range 70-85%) than placebo (58%). The most common side effects are nausea and hyperuricemia. The majority of studies report a prolongation of the QT interval in patients treated with Bedaquiline. Conclusion: This systematic review showed that Bedaquiline is effective and safe to use in the treatment of MDR-TB. However, serious side effects of QT prolongation occurred in some respondents treated with Bedaquiline. Further studies need to be conducted to monitor the side effects of QT prolongation associated with the administration of Bedaquiline in the treatment of MDR-TB.
An Overview of knowledge level of adolescent girls about anemia disease and prevention in Badung area, Bali Sari, Gusti Ayu Putu Laksmi Puspa; Wibowo, Yosi Irawati; Yana, I Gusti Agung Ari Kusuma; Megawati, Fitria
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Introduction: Adolescent anemia in Indonesia is still a high health problem, despite the implementation of government programs related to adolescent anemia prevention. Knowledge is one of the factors and influences the success of anemia prevention programs in adolescents. Objective: To provide an overview of knowledge related to blood supplement tablets and anemia in adolescent girls in Badung area. Methods: A survey study using a questionnaire was conducted on 193 adolescent girls enrolled in one of the junior high schools in Badung. There were twenty knowledge questions related to blood supplement tablets and anemia. Data were analyzed descriptively based on the variables measured. Results: The knowledge level of adolescent girls mostly had sufficient knowledge (74.6%), good knowledge (11.9%) and poor knowledge (13.5%). Conclusion: In this study, there were still adolescent girls who had insufficient knowledge. Educational efforts need to be made in various approaches to improve the knowledge of adolescent girls.
An Overview of knowledge level of adolescent girls about anemia disease and prevention in Badung area, Bali Sari, Gusti Ayu Putu Laksmi Puspa; Wibowo, Yosi Irawati; Yana, I Gusti Agung Ari Kusuma; Megawati, Fitria
Pharmaceutical Journal of Indonesia Vol. 10 No. 2 (2025)
Publisher : Brawijaya University

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/

Abstract

Introduction: Adolescent anemia in Indonesia is still a high health problem, despite the implementation of government programs related to adolescent anemia prevention. Knowledge is one of the factors and influences the success of anemia prevention programs in adolescents. Objective: To provide an overview of knowledge related to blood supplement tablets and anemia in adolescent girls in Badung area. Methods: A survey study using a questionnaire was conducted on 193 adolescent girls enrolled in one of the junior high schools in Badung. There were twenty knowledge questions related to blood supplement tablets and anemia. Data were analyzed descriptively based on the variables measured. Results: The knowledge level of adolescent girls mostly had sufficient knowledge (74.6%), good knowledge (11.9%) and poor knowledge (13.5%). Conclusion: In this study, there were still adolescent girls who had insufficient knowledge. Educational efforts need to be made in various approaches to improve the knowledge of adolescent girls.