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All Journal Jurnal Informasi Kesehatan Indonesia (JIKI) Jurnal Kebidanan (JBd) Poltekkes Kemenkes Maluku
Asri Iman Sari
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AKTIVITAS ANTIOKSIDAN KITOSAN PADA OVARIUM TIKUS BETINA YANG TERPAPAR TIMBAL (Pb) ASETAT asri iman sari
Jurnal Informasi Kesehatan Indonesia (JIKI) Vol 4 No 2 (2018): Jurnal Informasi Kesehatan Indonesia
Publisher : Politeknik Kesehatan Kemenkes Malang (State Health Polytechnic of Malang)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jiki.v(4)i(2)y(2018).page:80-86

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh kitosan terhadap ekspresi Bax dan jumlah atresia folikel pada ovarium tikus betina yang terpapar timbal asetat. Penentuan sampel dilakukan secara random, 25 ekor tikus betina sesuai kriteria inklusi dan ekslusi dibagi menjadi 5 kelompok. Semua kelompok, kecuali kelompok kontrol negatif diberi timbal asetat 175 mg/kg BB. Kelompok perlakuan 1, 2, dan 3 diberi kitosan yang dilarutkan dalam asam asetat 2% dengan dosis 16, 32, dan 64 mg/kg BB. Pemberian timbal asetat dan kitosan melalui sonde per oral. Aklimatisasai dilakukan selama 7 hari dan perlakuan selama 30 hari. Hari ke 31 dilakukan swab vagina. Jika tikus pada fase proestrus maka tikus dibedah dan diambil ovariumnya. Pengukuran ekspresi Bax menggunakan metode imunohistokimia dan penghitungan jumlah folikel atresia menggunakan metode hematoksilin eosin yang dilihat dengan mikroskop Olympus pembesaran 400x. Hasil penelitian menunjukkan bahwa kelompok perlakuan yang diberi timbal asetat dan kitosan berbagai dosis memiliki ekspresi Bax dan jumlah atresia folikel yang berbeda signifikan dengan kelompok kontrol negatif. Kata kunci: kitosan, antioksidan, timbal asetat ABSTRACT This research aims the effect of chitosan on bax expression and the number of follicle atresia in the ovary of female rat exposed lead acetate. Twenty five rats were divided into 5 treatment groups. All groups, except negative control group, were administered by 175 mg/kg BW oral lead acetate. Treatment group 1, 2, and 3 were treated using chitosan in dose of 16, 32, and 64 mg/kg BW dissolved in 2% acetic acid, respectively in 30 days. Before treated rat need acclimatization in 7 days. Administration of lead acetate and chitosan via sonde orally. Vaginal swabs in day 31, if rat in proestrus phase dissected and taken the ovary. Bax expression calculation with immunohistochemistry method and the number of follicle atresia calculation with hematoksilin eosin method. And then viewed use Olympus microscope zoom in 400. Results showed that Chitosan-treated groups in bax expression ang the number of follicle atresia differ significantly with negative control group. Keywords: chitosan, antioxidant, lead acetate
AKTIVITAS ANTIOKSIDAN KITOSAN PADA OVARIUM TIKUS BETINA YANG TERPAPAR TIMBAL (Pb) ASETAT asri iman sari
Jurnal Informasi Kesehatan Indonesia (JIKI) Vol 4 No 2 (2018): Jurnal Informasi Kesehatan Indonesia
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jiki.v4i2.341

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh kitosan terhadap ekspresi Bax dan jumlah atresia folikel pada ovarium tikus betina yang terpapar timbal asetat. Penentuan sampel dilakukan secara random, 25 ekor tikus betina sesuai kriteria inklusi dan ekslusi dibagi menjadi 5 kelompok. Semua kelompok, kecuali kelompok kontrol negatif diberi timbal asetat 175 mg/kg BB. Kelompok perlakuan 1, 2, dan 3 diberi kitosan yang dilarutkan dalam asam asetat 2% dengan dosis 16, 32, dan 64 mg/kg BB. Pemberian timbal asetat dan kitosan melalui sonde per oral. Aklimatisasai dilakukan selama 7 hari dan perlakuan selama 30 hari. Hari ke 31 dilakukan swab vagina. Jika tikus pada fase proestrus maka tikus dibedah dan diambil ovariumnya. Pengukuran ekspresi Bax menggunakan metode imunohistokimia dan penghitungan jumlah folikel atresia menggunakan metode hematoksilin eosin yang dilihat dengan mikroskop Olympus pembesaran 400x. Hasil penelitian menunjukkan bahwa kelompok perlakuan yang diberi timbal asetat dan kitosan berbagai dosis memiliki ekspresi Bax dan jumlah atresia folikel yang berbeda signifikan dengan kelompok kontrol negatif. Kata kunci: kitosan, antioksidan, timbal asetat ABSTRACT This research aims the effect of chitosan on bax expression and the number of follicle atresia in the ovary of female rat exposed lead acetate. Twenty five rats were divided into 5 treatment groups. All groups, except negative control group, were administered by 175 mg/kg BW oral lead acetate. Treatment group 1, 2, and 3 were treated using chitosan in dose of 16, 32, and 64 mg/kg BW dissolved in 2% acetic acid, respectively in 30 days. Before treated rat need acclimatization in 7 days. Administration of lead acetate and chitosan via sonde orally. Vaginal swabs in day 31, if rat in proestrus phase dissected and taken the ovary. Bax expression calculation with immunohistochemistry method and the number of follicle atresia calculation with hematoksilin eosin method. And then viewed use Olympus microscope zoom in 400. Results showed that Chitosan-treated groups in bax expression ang the number of follicle atresia differ significantly with negative control group. Keywords: chitosan, antioxidant, lead acetate
HUBUNGAN PREMENSTRUAL SYNDROME DENGAN KUALITAS TIDUR SISWI MTs. ZAINUL HASAN Aprilia Kusuma Wardani; Melati Puspita Sari; Asri Iman Sari; Trisna Pangestuning Tyas
Jurnal Kebidanan Vol 6 No 1 (2026): Jurnal Kebidanan (JBd)
Publisher : Poltekkes Kemenkes Maluku

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.32695/jbd.v6i1.814

Abstract

Background: Premenstrual Syndrome (PMS) is a set of physical, emotional, and behavioral symptoms that appear before menstruation and usually subside afterward. Hormonal imbalances of estrogen and progesterone are among the triggering factors for PMS symptoms. These imbalances can affect the central nervous system through a decrease in serotonin and melatonin levels, which play an important role in regulating mood and the sleep cycle. As a result, many women experience sleep disturbances before menstruation. At MTs. Zainul Hasan Balung, 48 out of 90 students (53.3%) experience PMS.Objective: To analyze the relationship between the occurrence of premenstrual syndrome and sleep quality among female students at MTs. Zainul Hasan. Methods: This research is a quantitative analytic study with data collected observationally. The sample consisted of 48 female students at MTs. Zainul Hasan, selected using a purposive sampling technique. Data were analyzed using the Chi-square test. Results: The study found that 20 students (41.7%) experienced mild PMS symptoms, 23 students (47.9%) experienced moderate PMS symptoms, and 5 students (10.4%) experienced severe PMS symptoms. In terms of sleep quality, 28 students (58.3%) had poor sleep quality, while 20 students (41.7%) had good sleep quality. Data analysis using the Chi-square test yielded a p-value of 0.000 (<0.05) and a correlation coefficient of 0.554. Conclusion: There is a moderate association between premenstrual syndrome and sleep quality among female students at MTs. Zainul Hasan. Recommendation: Advice for female students to take steps to relieve PMS symptoms, such as regular exercise, which will improve the quality of sleep.
Co-Authors Aprilia Kusuma Wardani Melati Puspita Sari RIRIN HANDAYANI Trisna Pangestuning Tyas Yuningsih Yuningsih