Article Per Year (5 Year)
p-Index From 2020 - 2025
0.23
P-Index
This Author published in this journals
All Journal Jurnal Informasi Kesehatan Indonesia (JIKI) Jurnal Kesehatan dr. Soebandi
Asri Iman Sari
Unknown Affiliation
Health Professions Medicine & Pharmacology Nursing Public Health

Published : 3 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 3 Documents
Search

 1 
AKTIVITAS ANTIOKSIDAN KITOSAN PADA OVARIUM TIKUS BETINA YANG TERPAPAR TIMBAL (Pb) ASETAT asri iman sari
Jurnal Informasi Kesehatan Indonesia (JIKI) Vol 4 No 2 (2018): Jurnal Informasi Kesehatan Indonesia
Publisher : Politeknik Kesehatan Kemenkes Malang (State Health Polytechnic of Malang)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jiki.v(4)i(2)y(2018).page:80-86

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh kitosan terhadap ekspresi Bax dan jumlah atresia folikel pada ovarium tikus betina yang terpapar timbal asetat. Penentuan sampel dilakukan secara random, 25 ekor tikus betina sesuai kriteria inklusi dan ekslusi dibagi menjadi 5 kelompok. Semua kelompok, kecuali kelompok kontrol negatif diberi timbal asetat 175 mg/kg BB. Kelompok perlakuan 1, 2, dan 3 diberi kitosan yang dilarutkan dalam asam asetat 2% dengan dosis 16, 32, dan 64 mg/kg BB. Pemberian timbal asetat dan kitosan melalui sonde per oral. Aklimatisasai dilakukan selama 7 hari dan perlakuan selama 30 hari. Hari ke 31 dilakukan swab vagina. Jika tikus pada fase proestrus maka tikus dibedah dan diambil ovariumnya. Pengukuran ekspresi Bax menggunakan metode imunohistokimia dan penghitungan jumlah folikel atresia menggunakan metode hematoksilin eosin yang dilihat dengan mikroskop Olympus pembesaran 400x. Hasil penelitian menunjukkan bahwa kelompok perlakuan yang diberi timbal asetat dan kitosan berbagai dosis memiliki ekspresi Bax dan jumlah atresia folikel yang berbeda signifikan dengan kelompok kontrol negatif. Kata kunci: kitosan, antioksidan, timbal asetat ABSTRACT This research aims the effect of chitosan on bax expression and the number of follicle atresia in the ovary of female rat exposed lead acetate. Twenty five rats were divided into 5 treatment groups. All groups, except negative control group, were administered by 175 mg/kg BW oral lead acetate. Treatment group 1, 2, and 3 were treated using chitosan in dose of 16, 32, and 64 mg/kg BW dissolved in 2% acetic acid, respectively in 30 days. Before treated rat need acclimatization in 7 days. Administration of lead acetate and chitosan via sonde orally. Vaginal swabs in day 31, if rat in proestrus phase dissected and taken the ovary. Bax expression calculation with immunohistochemistry method and the number of follicle atresia calculation with hematoksilin eosin method. And then viewed use Olympus microscope zoom in 400. Results showed that Chitosan-treated groups in bax expression ang the number of follicle atresia differ significantly with negative control group. Keywords: chitosan, antioxidant, lead acetate
AKTIVITAS ANTIOKSIDAN KITOSAN PADA OVARIUM TIKUS BETINA YANG TERPAPAR TIMBAL (Pb) ASETAT asri iman sari
Jurnal Informasi Kesehatan Indonesia (JIKI) Vol 4 No 2 (2018): Jurnal Informasi Kesehatan Indonesia
Publisher : Politeknik Kesehatan Kemenkes Malang

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.31290/jiki.v4i2.341

Abstract

ABSTRAK Penelitian ini bertujuan untuk mengetahui pengaruh kitosan terhadap ekspresi Bax dan jumlah atresia folikel pada ovarium tikus betina yang terpapar timbal asetat. Penentuan sampel dilakukan secara random, 25 ekor tikus betina sesuai kriteria inklusi dan ekslusi dibagi menjadi 5 kelompok. Semua kelompok, kecuali kelompok kontrol negatif diberi timbal asetat 175 mg/kg BB. Kelompok perlakuan 1, 2, dan 3 diberi kitosan yang dilarutkan dalam asam asetat 2% dengan dosis 16, 32, dan 64 mg/kg BB. Pemberian timbal asetat dan kitosan melalui sonde per oral. Aklimatisasai dilakukan selama 7 hari dan perlakuan selama 30 hari. Hari ke 31 dilakukan swab vagina. Jika tikus pada fase proestrus maka tikus dibedah dan diambil ovariumnya. Pengukuran ekspresi Bax menggunakan metode imunohistokimia dan penghitungan jumlah folikel atresia menggunakan metode hematoksilin eosin yang dilihat dengan mikroskop Olympus pembesaran 400x. Hasil penelitian menunjukkan bahwa kelompok perlakuan yang diberi timbal asetat dan kitosan berbagai dosis memiliki ekspresi Bax dan jumlah atresia folikel yang berbeda signifikan dengan kelompok kontrol negatif. Kata kunci: kitosan, antioksidan, timbal asetat ABSTRACT This research aims the effect of chitosan on bax expression and the number of follicle atresia in the ovary of female rat exposed lead acetate. Twenty five rats were divided into 5 treatment groups. All groups, except negative control group, were administered by 175 mg/kg BW oral lead acetate. Treatment group 1, 2, and 3 were treated using chitosan in dose of 16, 32, and 64 mg/kg BW dissolved in 2% acetic acid, respectively in 30 days. Before treated rat need acclimatization in 7 days. Administration of lead acetate and chitosan via sonde orally. Vaginal swabs in day 31, if rat in proestrus phase dissected and taken the ovary. Bax expression calculation with immunohistochemistry method and the number of follicle atresia calculation with hematoksilin eosin method. And then viewed use Olympus microscope zoom in 400. Results showed that Chitosan-treated groups in bax expression ang the number of follicle atresia differ significantly with negative control group. Keywords: chitosan, antioxidant, lead acetate
The Relationship Between Nutritional Status And The Development Of Children Aged 4-60 Months Yuningsih, Yuningsih; Ai Nur Zannah; Asri Iman Sari; Ririn Handayani
Jurnal Kesehatan dr. Soebandi Vol 12 No 2 (2024): Jurnal Kesehatan dr. Soebandi
Publisher : Lembaga Penelitian dan Pengabdian Masyarakat Universitas dr. Soebandi

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36858/jkds.v12i2.689

Abstract

Child development is an important aspect of human life, especially in the early period of life, which is often referred to as the critical or golden period as the child's brain undergoes rapid growth. Developmental disorders in children under five, especially in terms of motor skills, have a long-term impact on their development, and a child's nutritional status has been shown to play a role in the process. Therefore, this study aims to determine the relationship between nutritional status and development of children aged 4-60 months in Jember Regency. The research method used was a quantitative correlational approach with a cross-sectional approach, involving a total of 57 children who had a Kartu Menuju Sehat (KMS) as the population. From the results of the formula calculation, the sample size was determined as 50 respondents using a non-randomized (non-probability) method, namely purposive sampling based on certain criteria. The research instruments involved the Kartu Menuju Sehat (KMS) to assess children's nutritional status and the Developmental Pre-Screening Questionnaire (KPSP) to identify children's development. The results of the chi-square statistical test revealed a significant relationship between nutritional status and development of children aged 4-60 months in Jember District. [ Children with good nutritional status show more optimal developmental progress, while children with poor nutritional status tend to experience slower or inappropriate development for their age. This finding supports theories that emphasize the importance of adequate nutrition for children's growth and development. Therefore, efforts to improve children's nutritional status should be a top priority in various child health and education programs. With the right understanding and action, we can help create a healthier and more potential future generation.
Co-Authors RIRIN HANDAYANI Yuningsih Yuningsih