Developing a predictive model is the objective of this study, focusing on vector-borne diseases using various machine learning methods, including Random Forest (RF), Logistic Regression (LR), k-nearest Neighbors (kNN), Tree (DT), and XGBoost. The main goal is to use oversampling techniques like SMOTE and Random Oversampling to correct the dataset's class imbalance. The dataset was obtained from Kaggle and literature references published in Frontiers in Ecology and Evolution (Endo and Amarasekare 2022), consisting of approximately 9,490 entries with environmental, demographic, and clinical attributes. Dengue Fever is one of the diseases that this study focuses on. Aedes aegypti mosquitoes spread it, and it is a significant health risk in tropical areas. The DT and XGBoost models had the highest accuracy, at 99.2%. Logistic Regression and Random Forest also did well, with 99.1% accuracy. KNN did well, too, but with a lower recall, at 99.0%. The ROC curve gave a complete picture of how well each model classified things. These findings indicate that when combined with proper data handling, machine learning models can significantly improve early detection of vector-borne diseases and support more accurate and timely decision-making in public health interventions.