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Analysis of the Role of SARS-CoV-2 Infection on Clinical Superficial Mycosis: An Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Ariani, Tutty; Andriani Fuji Lestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1080

Background: The COVID-19 pandemic, caused by SARS-CoV-2 infection, has had multiple impacts on human health, including its potential influence on the manifestation and severity of skin diseases such as superficial mycoses. This study aims to analyze the relationship between SARS-CoV-2 infection and the clinical characteristics of superficial mycosis in patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This analytical observational study included 150 patients with laboratory-confirmed superficial mycoses. Demographic data, medical history, SARS-CoV-2 infection status (based on RT-PCR results), and clinical characteristics of superficial mycoses were collected and analyzed using SPSS software. Results: Of the 150 patients studied, 75 patients had a history of SARS-CoV-2 infection. No significant differences were found in the distribution of gender, age, and location of superficial mycosis infections between the groups of patients with and without SARS-CoV-2 infection. However, patients with a history of SARS-CoV-2 infection tended to have a higher severity of superficial mycosis (p < 0.05). In addition, there was a significant difference in the type of agent causing superficial mycosis between the two groups (p < 0.01). Conclusion: SARS-CoV-2 infection may influence the clinical manifestations of superficial mycoses, especially in terms of disease severity. These findings support the importance of monitoring and management of superficial mycoses in patients with a history of SARS-CoV-2 infection.

A Rare Presentation of Type 2 Lepra Reaction: Necrotizing Erythema Nodosum Leprosum with Extensive Ulceration Ariani, Tutty; Clarissa Maharani Putri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1220

Background: Leprosy, primarily caused by Mycobacterium leprae, is a chronic infectious disease that mainly affects the skin and peripheral nerves. Type 2 leprosy reaction (ENL) is an immune complex-mediated complication characterized by inflammation of the skin, nerves, and other organs. A less common manifestation of ENL is necrotizing ENL, which presents with extensive skin necrosis and ulceration. This case report describes a rare presentation of necrotizing ENL with extensive ulceration in a young woman with borderline lepromatous leprosy. Case presentation: A 20-year-old female presented with multiple, progressively enlarging, painless ulcers on her right leg and painful reddish nodules on her left arm and left leg. She had a history of borderline lepromatous leprosy. Dermatological examination revealed madarosis, infiltration, nodules, hyperpigmentation macules, ulcers, and blackish crusts. Sensory testing showed hypoesthesia in the abdomen and back, and anesthesia in both lower arms and legs. Histopathological examination confirmed the diagnosis of necrotizing ENL. Conclusion: Necrotizing ENL is a rare and severe complication of leprosy. This case highlights the importance of early diagnosis and appropriate management with multi-drug therapy and corticosteroids to prevent significant morbidity and disability.

Onychodystrophy On Twenty Nails Caused By Candida Parapsilosis and Staphylococcus Aureus: A Case Report Ariani, Tutty
Health and Medical Journal Vol 4, No 2 (2022): HEME May 2022
Publisher : Universitas Baiturrahmah

Introduction: Onychodystrophy can caused by variety of underlying diseases such as fungal and nonfungal infections, various noninfectious inflammatory dermatologic diseases of the nail unit and tumors. To establish the underlying disease leading to nail dystrophy as a first step one should differentiate between infectious and noninfectious disorders by obtaining nail material for microscopic examination and culture. Case Report: A case of onychodystrophy on twenty nail in 43 years old housewife woman was reported. The chief complaint was all of her fingernails and toenails were brittle, the color became yellow brown blackish since 6 month ago and sometimes excreted smell discharge. There were onychodystrophy, onycholysis, subungual hyperkeratosis and yellow brown blackish discolorization of all fingernails and toenail on physical examination. There were longitudinal striae, aurora borealis pattern, jagged margin of proximal edge on dermoscopic examination. Microscopic examination of nail clipping and scrapping of fingernails with 20 % potassium hydroxide was negative. The culture of fungi showed Candida Parapsilosis. Culture of bacteria was Staphylococcus aureus. PAS stain from nail clipping resulted was Candida Spp. Patient treated with oral pulse antifungal itraconazole 2x200 mg/day combination with ciprofloxacin 2x500 mg twice a day and ketokonazol cream twice a day. Conclusion: Onychodystrophy can caused by onychomycosis aggravated by bacterial infection. Diagnosis of onychomycosis candida was made base on diagnosis, physical examination, microscopic, culture and histopatology. Predisposition factor in this patient was chronic exposure with water. There is improvement clinical appearance after therapy with antifungal and antibiotic

Clinical Appearance Of Tinea Corporis Resembles With Tinea Imbricata And Condyloma Acuminata Genital In A Reproductive Woman With HIV : A Case Report Kencana, Indah; Ariani, Tutty; Anum, Qaira; Rizal, Yosse
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.287-302.2021

Background: HIV (human immunodeficiency virus) is a virus that attacks the bodyâ€™s immune system that can cause immunodeficiency. Immunodeficiency results in increased susceptibility to fungal infections. The other opportunistic infection, condyloma acuminate is prevalent in groups at high risk for HIV acquisition and in HIV-infected individuals. Case: There were ring-shaped reddish patches with scaly and itchy on the right back since 3 weeks ago. Patients often scratch it especially when sweating and hot weather. The itchy reddish patches with scaly were increased in number and size on the right back then spreading over the edge to form ring-like patches. Patient complained ring-shaped reddish patches getting more red, scaly, itchy, and wider. 6 months ago, there was a lump that sometime felt itchy in below part of vulva. Patient in reproductive age and not married yet, but sexually active. Patient had a sexual relation with male who HIV 2 years ago. Patient also suffered HIV and got ARV since 6 month ago. There was no protection (condom) during the sexual intercourse. Dermatologic state in right back with efflorescence is plaque erythema with annular concentric ring forms, scale, and blackish crust. Venereologycal state show vegetation in vulva with size 0,2 - 1,5 x 1 x 0,5 cm with verrucous surface. Acetowhite test is positive result. KOH 10% of skin scrapping show fungal element and fungal culture result is tricophyton rubrum. Patient was diagnosed tinea corporis (TC) and condyloma acuminata (CA) genital griseovulfin 900 mg, cetirizin 10 mg, ketokonazol 2% cream twice a day, tricholoroacetat 90% and showed good improvement.Discussion: Diagnosis tinea corporis and CA genital based on clinical findings and mycological examination. Early diagnosis and proper treatment are important in HIV patients in order to prevent severe infection. After 4 weeks treatment, show improvement on TC however CA lesion no reduced. Keywords: tinea corporis,condyloma acuminate, tinea imbricata, HIV, Reproductive age

The qRT-PCR in A Nasal Swab Leprosy Patient’s at Dr. M. Djamil Padang Hospital Ariani, Tutty; Asri, Ennesta; Putra, Andani Eka
International Journal of Science and Society Vol 6 No 3 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i3.1222

Leprosy, caused by Mycobacterium leprae, in 2016, Indonesia reported 16,826 new leprosy cases, with a prevalence rate of 0.71 per 10,000 individuals and a new case detection rate of 6.5 per 10,000 individuals. This study describes the result of a quantitative real-time polymerase chain reaction (qRT-PCR) in the nasal mucosa smear of a leprosy patient at the Dermatology and Venereology Polyclinic of Dr. M. Djamil Padang Hospital. This study adopts an observational approach with a width cut design, specifically employing a cross-sectional study methodology on leprosy patient at the Dermatology and Venereology Polyclinic of Dr. M. Djamil Padang Hospital, Indonesia between February 2023 until February 2024. The qRT-PCR quantity value of nasal mucous discharge is analyzed by a real-time PCR machine. The provided data presents characteristics of a sample population (N = 36) with leprosy. The majority of the leprosy-affected individuals in this study are between 8 and 68 years old, with a median age of 34. According to the World Health Organization (WHO) classification indicates that 83.33% of cases are multibacillary (MB). A combination RLEP/ qRT-PCR assay was developed to enable laboratory-based care and follow-up of leprosy patients attending our outpatient polyclinic in M. Djamil, Padang. The assay offers a sensitive and precise method for assessing the bacterial load and viability of M. leprae from nasal swab samples. It can be used for treatment response monitoring and early diagnosis.

Analysis of the Role of SARS-CoV-2 Infection on Clinical Superficial Mycosis: An Observational Study at Dr. M. Djamil General Hospital, Padang, Indonesia Ariani, Tutty; Andriani Fuji Lestari
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 8 No. 10 (2024): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v8i10.1080

Background: The COVID-19 pandemic, caused by SARS-CoV-2 infection, has had multiple impacts on human health, including its potential influence on the manifestation and severity of skin diseases such as superficial mycoses. This study aims to analyze the relationship between SARS-CoV-2 infection and the clinical characteristics of superficial mycosis in patients at Dr. M. Djamil General Hospital, Padang, Indonesia. Methods: This analytical observational study included 150 patients with laboratory-confirmed superficial mycoses. Demographic data, medical history, SARS-CoV-2 infection status (based on RT-PCR results), and clinical characteristics of superficial mycoses were collected and analyzed using SPSS software. Results: Of the 150 patients studied, 75 patients had a history of SARS-CoV-2 infection. No significant differences were found in the distribution of gender, age, and location of superficial mycosis infections between the groups of patients with and without SARS-CoV-2 infection. However, patients with a history of SARS-CoV-2 infection tended to have a higher severity of superficial mycosis (p < 0.05). In addition, there was a significant difference in the type of agent causing superficial mycosis between the two groups (p < 0.01). Conclusion: SARS-CoV-2 infection may influence the clinical manifestations of superficial mycoses, especially in terms of disease severity. These findings support the importance of monitoring and management of superficial mycoses in patients with a history of SARS-CoV-2 infection.

A Rare Presentation of Type 2 Lepra Reaction: Necrotizing Erythema Nodosum Leprosum with Extensive Ulceration Ariani, Tutty; Clarissa Maharani Putri
Bioscientia Medicina : Journal of Biomedicine and Translational Research Vol. 9 No. 3 (2025): Bioscientia Medicina: Journal of Biomedicine & Translational Research
Publisher : HM Publisher

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37275/bsm.v9i3.1220

Background: Leprosy, primarily caused by Mycobacterium leprae, is a chronic infectious disease that mainly affects the skin and peripheral nerves. Type 2 leprosy reaction (ENL) is an immune complex-mediated complication characterized by inflammation of the skin, nerves, and other organs. A less common manifestation of ENL is necrotizing ENL, which presents with extensive skin necrosis and ulceration. This case report describes a rare presentation of necrotizing ENL with extensive ulceration in a young woman with borderline lepromatous leprosy. Case presentation: A 20-year-old female presented with multiple, progressively enlarging, painless ulcers on her right leg and painful reddish nodules on her left arm and left leg. She had a history of borderline lepromatous leprosy. Dermatological examination revealed madarosis, infiltration, nodules, hyperpigmentation macules, ulcers, and blackish crusts. Sensory testing showed hypoesthesia in the abdomen and back, and anesthesia in both lower arms and legs. Histopathological examination confirmed the diagnosis of necrotizing ENL. Conclusion: Necrotizing ENL is a rare and severe complication of leprosy. This case highlights the importance of early diagnosis and appropriate management with multi-drug therapy and corticosteroids to prevent significant morbidity and disability.

Borderline Lepromatous Leprosy with Mild Reversal Reaction in Child Fonna, Nellia; Ariani, Tutty; Rizal, Yosse; Yenny, Satya Wydya
Frontiers on Healthcare Research Vol. 1 No. 1 (2024)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v1.n1.p7-11.2024

Background: Childhood leprosy is an important marker of the status of the ongoing leprosy control program, as it is an indicator of active disease transmission in the community. Children are believed to be the most vulnerable group to infection with M. leprae due to their immature or nascent immunity and exposure to intrafamilial contacts. Case report: A 8 years ole male patient presented with hypopigmented patch and erythematous patch with not itchy, not pain, and loss of sensation which increasing more since 1 week ago. Initially 2 months ago, white patch that felt numbness appeared on the back, then white patches wider and spread to the chest, both arms and thighs. Dermatologic finding showed erythematous plaques, hypopigmentation macule with infiltration on cheek, back, both of arms, xerosis cutis. Decreased sensory function was found in the median, ulnar and posteriol tibial nerves. Acid-fast bacilli (AFB) staining revealed bacterial index (BI) +5 and morphological index (MI) 80%. Histopathological examination showed atrophic stratified squamous epithelium, grenz zone, many groups of foamy macrophages reached the fat layer. The patient was diagnosed Morbus Hansen borderline lepromatous leprosy type with mild reversal reaction and treated with MDT-MB drug package, vitamin B complex tablet, zinc tablet, paracetamol tablet, and 10% urea cream on dry skin 2 times a day on dry skin after bath during 2 month and the lesion was reduced. Conclusion: The rate of childhood leprosy continues to be a significant problem. There is a clear need to strengthen early detection, treatment, and regular follow up of these cases in both high and low endemic setting is essential in the prevention of deformities.

Epidemiology and Clinical Patterns of Leprosy: A Retrospective Study at Dr. M. Djamil General Hospital, Padang, Indonesia Ariani, Tutty; Triani , Aisha; Aulia , Salsabila Syafna
Frontiers on Healthcare Research Vol. 2 No. 2 (2025)
Publisher : Rumah Sakit Umum Pusat (RSUP) Dr. M. Djamil

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.63918/fhr.v2.n2.p35-44.2025

Background: Indonesia ranks third globally in the number of leprosy cases, following Brazil and India. Despite this, leprosy remains a neglected disease. Monitoring its epidemiology through retrospective studies is essential to inform effective disease control programs. Methods: This retrospective descriptive study reviewed medical records of leprosy patients who visited Dr. M. Djamil General Hospital, Padang, between 2021 and mid-2024. Data were extracted from patients’ electronic medical records. Results: A total of 92 patients were confirmed with leprosy during the study period. The incidence increased from 13 patients in 2021 to 22 in 2022, and 40 in 2023, with 17 additional cases identified by mid-2024. Of these, 70 (76.1%) were multibacillary cases and 22 (23.9%) were paucibacillary cases. Male patients predominated, with a mean age of 35 years (range: 7–79 years). Leprosy reactions occurred in 44 patients (47.8%), consisting of 20 (45.5%) reversal reactions and 24 (54.5%) erythema nodosum leprosum (ENL). Most cases originated from Pesisir Selatan Regency and Pariaman City, both recognized as high-endemic areas in West Sumatra Province. Conclusion: The incidence of leprosy is rising annually, with multibacillary cases predominating. Male patients are more frequently affected, and nearly half experience leprosy reactions, with ENL more common than reversal reactions. Strengthened disease control strategies are urgently needed to detect and reduce new cases in endemic regions. Study limitations include reliance on retrospective medical record data and a single tertiary hospital setting.

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