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All Journal Majalah Kedokteran Bandung Berkala Ilmu Kesehatan Kulit dan Kelamin Indonesian Journal of Global Health research International Journal of Science and Society (IJSOC) Journal of General Procedural Dermatology and Venereology Indonesia Seroja Husada: Jurnal Kesehatan Masyarakat
Asri, Ennesta
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Dentistry Education Health Professions Immunology & microbiology Languange, Linguistic, Communication & Media Materials Science & Nanotechnology Medicine & Pharmacology Nursing Public Health Social Sciences Veterinary

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A Case of Longitudinal Melanonychia in A Child: Benign or Malignant? Putri, Heffi Anindya; Asri, Ennesta; Anum, Qaira
Journal of General - Procedural Dermatology & Venereology Indonesia Vol. 6, No. 2
Publisher : UI Scholars Hub

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Abstract

Background: Longitudinal melanonychia (LM) describes a longitudinal brown-to-black band of discoloration affecting a finger, thumb, or toenail. Discoloration of the nails can be a sign of benign or malignant nail disorders. Although nail melanoma rarely occurs in children, health practitioners should be aware of melanonychia. Dermoscopy and histopathology are helpful in the diagnosis. Case Illustration: A case of LM in a thirteen-year-old girl was reported with a complaint of brownish-black discoloration, sometimes painful, on her right thumb since 1 year ago. She had no history of trauma, nail damage, or bleeding tendency. Dermatological examination found a homogeneous brownish-black band on the right thumbnail. Dermoscopy revealed regular, homogeneous black linear pigmentation and pigment through the translucent cuticle and proximal nail fold (pseudo-Hutchinson’s sign). Punch biopsy was done on proximal nail fold reaching nail matrix. Histopathology revealed increased melanocytes, some nests of melanocytes in rete Malpighi, and no atypical cells. She was diagnosed with nail matrix nevus. Five months after the punch biopsy, the nail grew well without onychodystrophy. Discussion: Nail matrix nevus is a benign LM. Diagnosis is based on anamnesis, physical examination, dermoscopy, and histopathology. Dermoscopy of the nails is a useful, quick, non-invasive, and highly effective tool that may help differentiate benign or malign melanonychia. Conclusion: Histopathology is important to determine whether the pigmented lesion is benign or malignant.
Profil Pasien Lupus Eritematosus Kutaneus di Rumah Sakit Umum Pusat Dr M Djamil Padang Periode 2015 - 2020 Tiffany, Begum; Akhyar, Gardenia; Revilla, Gusti; Asri, Ennesta; Tofrizal, Tofrizal; Afriani, Nita
Seroja Husada: Jurnal Kesehatan Masyarakat Vol. 1 No. 6 (2024): Seroja Husada: Jurnal Kesehatan Masyarakat
Publisher : Seroja Husada: Jurnal Kesehatan Masyarakat

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Lupus eritematosus kutaneus (LEK) merupakan salah satu dari jenis penyakit lupus eritematosus (LE) yang merupakan penyakit autoimun dengan variasi klinis luas. Walaupun penyebab lupus jenis manapun belum jelas diketahui, salah satu faktor pencetus yang mungkin jadi penyebab penyakit ini adalah faktor hormon, paparan sinar matahari, dan faktor lainnya. Sama seperti lupus eritematosus lainnya, LEK lebih sering terjadi pada wanita usia subur dibandingkan dengan laki laki dengan manifestasi klinis yang muncul di kulit yang dapat dipicu karena paparan sinar matahari. Hal ini ditambah dengan manifestasi klinis lain selain manifestasi pada kulit yang juga muncul, dapat menimbulkan masalah yang mempengaruhi kualitas hidup penderitanya.Tujuan dari penelitian ini adalah untuk mengetahui profil klinis pasien LEK di RSUP Dr M Djamil Padang periode 2015-2020. Populasi dalam penelitian ini adalah seluruh pasien LEK di RSUP Dr M Djamil Padang periode 2015-2020, dengan total 20 data. Data sekunder berupa rekam medis pasien LEK digunakan dalam penelitian ini, dan disajikan dalam bentuk narasi dan tabel distribusi frekuensi.Hasil penelitian ini diperoleh jumlah penderita LEK di Rumah Sakit Umum Pusat Dr M Djamil Padang tahun 2015 - 2020 adalah sebanyak 17 orang penderita LES dan LEK, dan 3 orang penderita LEK saja dari 354 orang penderita LE. Jumlah pasien LEK perempuan jauh lebih banyak dari pasien laki laki. Distribusi kelompok umur terbanyak adalah berusia 15-24 tahun.
Non-Metallic and Metallic Toxicant Exposures from Personal Care Products in Indonesian Male and Female Medical Students Putra, Alby Dwinanda; Syamsir, Elmatris; Yulistini, Yulistini; Khaira, Fathiyyatul; Asri, Ennesta; Ilmiawati, Cimi
Majalah Kedokteran Bandung Vol 55, No 4 (2023)
Publisher : Faculty of Medicine, Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15395/mkb.v55n4.3254

Abstract

Students can gain various benefits from their daily personal care products. However, the chemicals contained in these products may have adverse health effects. Regardless the inspection performed by regulatory agencies on these products, the products circulating in the market may still contain toxicants thus may jeopardize their safety for use. This study evaluated toxicant ingredients contained in personal care products used by male and female college students. This study was conducted from September to December 2022 on 23 male and 46 female college students of the Faculty of Medicine, Universitas Andalas, Indonesia. Data were collected using a 69-items validated questionnaire. Results were then presented as a distribution of products used categorized by body areas and potentially toxic metallic and non-metallic ingredients identified from their labels. Female college students used at least 10 personal care products, with a median of 19 products. Male students used at least four products and a median of eight products. Investigation on the label of skin, hair, eye, dental and oral, lips, and nail personal care products demonstrated the presence of metallic and non-metallic toxicants. Five metallic toxicants (aluminum, titanium, zinc, copper, and chromium) and 15 non-metallic toxicants (triclosan, talc, fragrance, parabens, butylated hydroxyanisole, butylated hydroxytoluene, diethanolamine, triethanolamine, butylene glycol, propylene glycol, polyethylene glycol, phthalates, benzophenone-3, acetone, and fluoride) were identified. Thus, numerous toxicants are present in marketed personal care products, and females are exposed more than males to these toxicants. Consumers need to be more critical in their choice of personal care products.
The Effect of Alpha Mangostin on The Expression of TGF-β1, SMAD3, Type I Collagen, Proliferation and Migration of Keloid Fibroblasts Asri, Ennesta; Rina Gustia; Indah Indria Sari; Jefrizal Wirman; Yufaz Aidi Mahesa
Berkala Ilmu Kesehatan Kulit dan Kelamin Vol. 37 No. 1 (2025): APRIL
Publisher : Faculty of Medicine, Universitas Airlangga

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20473/bikk.V37.1.2025.41-47

Abstract

Background: Keloid is a process of abnormal collagen thickening during wound healing in skin tissue accompanied by the formation of new blood vessels. Many keloid therapy modalities have been developed but the recurrence rate of those treatment still ranged 1-70%. Herbal plants have been developed for various types of treatment, one of which is for treating keloids. Purpose: The alpha mangostin content in mangosteen peel is known to have antifibrotic properties, further research is needed regarding the administration of alpha mangostin on the process of keloid occurrence. Methods: The investigation was conducted in vitro on phase III keloid fibroblast cells. There were two groups, which divided into the control groups and the treatment groups. The control groups and treatment groups were given alpha mangostin extract in concentrations of 20 μM; the sample of this study was 16. For each group after 24h of the incubation, fibroblast cell proliferation was measured by Microtetrazolium (MTT) assay, fibroblast cell migration was measured by scratch assay, SMAD3 expression was measured after immunocytochemical staining, and type 1 collagen was measured by Enzyme-Linked Immunosorbent Assay (ELISA). The Ethics Committee at the Research Ethics Commission of Faculty of Medicine Andalas University has reviewed this research. Result: Alpha mangostin can reduce the average expression of TGF-β1, SMAD3 expression, type 1 collagen, proliferation, and migration.  . Conclusion: At concentration of 20 μM, alpha mangostin suppressed TGF-β1 expression, SMAD 3, collagen type 1, proliferation, and migration in keloid fibroblast cell.
Profile of Trichoepithelioma Patients at Hospital for the Period of 2016-2021 Hannum, Fauziah; Asri, Ennesta; Syahrul, Muhammad Zulfadli
Indonesian Journal of Global Health Research Vol 6 No 6 (2024): Indonesian Journal of Global Health Research
Publisher : GLOBAL HEALTH SCIENCE GROUP

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.37287/ijghr.v6i6.3802

Abstract

Trichoepithelioma is a rare benign tumor of the skin adnexa, of the pilosebaceous unit, especially of the hair follicle. This tumor is characterized by the appearance of lesions in the form of papules or nodules that are the color of the skin, with a size of 2-8 mm which can have solitary or multiple distribution. Trichoepithelioma has a psychosocial impact for sufferers, because trichoepithelioma lesions are often found on the face so that many sufferers feel embarrassed. This study is a retrospective descriptive study with a cross-sectional design that aims to determine the profile of trichoepithelioma based on age, gender, clinical picture, predilection site, duration before therapy, histopathological examination, treatment modality, and recurrence after therapy. From the 15 samples studied, it was found that the age group 11-19 years was the age group with the most trichoepithelioma patients (66.7%) with the highest gender being female (66.7%). All patients had clinical features of multiple trichoepithelioma (100%) with the greatest predilection for the nose (34.1%). Most of the patients had the same family history as the patient (66.7%). The duration of most patients 6 years (53.3%). Most of the patients did not perform histopathological examination (53.3%). The modality of therapy given to all patients was electrocautery with curettage (100%). Most of the patients did not follow up again regarding their recurrence (60%). Meanwhile, the most patients who did follow-up related to recurrence were <1 year (33.3%).
The qRT-PCR in A Nasal Swab Leprosy Patient’s at Dr. M. Djamil Padang Hospital Ariani, Tutty; Asri, Ennesta; Putra, Andani Eka
International Journal of Science and Society Vol 6 No 3 (2024): International Journal of Science and Society (IJSOC)
Publisher : GoAcademica Research & Publishing

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.54783/ijsoc.v6i3.1222

Abstract

Leprosy, caused by Mycobacterium leprae, in 2016, Indonesia reported 16,826 new leprosy cases, with a prevalence rate of 0.71 per 10,000 individuals and a new case detection rate of 6.5 per 10,000 individuals. This study describes the result of a quantitative real-time polymerase chain reaction (qRT-PCR) in the nasal mucosa smear of a leprosy patient at the Dermatology and Venereology Polyclinic of Dr. M. Djamil Padang Hospital. This study adopts an observational approach with a width cut design, specifically employing a cross-sectional study methodology on leprosy patient at the Dermatology and Venereology Polyclinic of Dr. M. Djamil Padang Hospital, Indonesia between February 2023 until February 2024. The qRT-PCR quantity value of nasal mucous discharge is analyzed by a real-time PCR machine. The provided data presents characteristics of a sample population (N = 36) with leprosy. The majority of the leprosy-affected individuals in this study are between 8 and 68 years old, with a median age of 34. According to the World Health Organization (WHO) classification indicates that 83.33% of cases are multibacillary (MB). A combination RLEP/ qRT-PCR assay was developed to enable laboratory-based care and follow-up of leprosy patients attending our outpatient polyclinic in M. Djamil, Padang. The assay offers a sensitive and precise method for assessing the bacterial load and viability of M. leprae from nasal swab samples. It can be used for treatment response monitoring and early diagnosis.
Co-Authors Adiba, Yasmine Shofi Aningdia Afriani, Nita Andani Eka Putra Anum, Qaira Ariani, Tutty Asterina, Asterina Cimi Ilmiawati, Cimi Fathiyyatul Khaira, Fathiyyatul Gardenia Akhyar Gusti Revilla Hannum, Fauziah Indah Indria Sari Jefrizal Wirman Putra, Alby Dwinanda Putri, Heffi Anindya Rina Gustia Syahrul, Muhammad Zulfadli Syamsir, Elmatris Tiffany, Begum Tofrizal Yufaz Aidi Mahesa Yulistini, Yulistini