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All Journal Jurnal Kesehatan Andalas Indonesian Journal of Cardiology Andalas obstetrics and gynecology journal
Rasyid, Hauda El
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Nursing Public Health

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Analisa Kadar Glutamat pada Penderita Fibrilasi Atrium dengan Gangguan Fungsi Kognitif Syafrita, Yuliarni; Andy, Marfri; Rasyid, Hauda El
Jurnal Kesehatan Andalas Vol. 9 No. 4 (2020): Online December 2020
Publisher : Faculty of Medicine, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jka.v9i4.1571

Abstract

Salah satu permasalahan neurologi yang ditemukan pada penderita fibrilasi atrium (FA) adalah gangguan kognitif. Silent Brain Infarction (SBI) diyakini menjadi salah satu mekanisme utama yang mendasari terjadinya gangguan ini. Sudah dilaporkan juga bahwa hipoksia serebri akan menimbulkan peningkatan kadar glutamat ektraseluler sehingga bersifat neurotoksisitas dan menimbulkan kematian sel. Tujuan: Menganalisis  kadar serum glutamat pada pasien Fibrilasi Atrial (FA) dengan gangguan kognitif.  Metode: Penelitian dengan disain potong lintang dilakukan di Poliklinik Kardiologi dan Neurologi RS DR M Djamil Padang serta Laboratorium Biomed Fakultas Kedokteran Universitas Andalas. Pemeriksaan kadar glutamat serum dilakukan dengan metode Elisa dan pemeriksaan fungsi kognitif dengan test neuropsikologi Montreal Cognitive Assestment versi Indonesia (MoCA-Ina). Perbedaan kadar glutamat serum pada kelompok FA dengan gangguan kognitif dan kelompok FA tanpa gangguan kognitif diuji dengan t test bila distribusi data normal dan test Mann Whitney bila data tidak terdistribusi normal. Hubungan antara kadar glutamat dengan kejadian gangguan kognitif dilakukan dengan uji Chi-square, setelah dicari dulu nilai cut off point untuk kadar glutamat serum. Uji dikatakan bermakna bila nilai p < 0,05. Hasil: Kadar glutamat serum kelompok FA dengan ganggan kognitif lebih tinggi dari kelompok FA tanpa gangguan kognitif. Pasien FA yang mempunyai kadar glutamat tinggi ( > 29,5µMol/L) beresiko mengalami gangguan kognitif 10,2 kali lebih tinggi dari penderita yang mempunyai kadar glutamat normal (< 29,5 µMol). Simpulan: Ada hubungan antara kadar glutamat serum dengan terjadinya gangguan kognitif pada penderita FA.Kata kunci: fibrilasi atrial, fungsi kognitif, glutamat, silent brain infarction
Comparison of right ventricular global longitudinal strain between pacemaker lead position in patients with permanent pacemaker Fakhri, Muhamad; Rasyid, Hauda El; Yanni, Mefri; Machmud, Rizanda
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1592

Abstract

Background: The implantation of a permanent pacemaker (PPM) can reduce right ventricular function. Echocardiography using speckle tracking can detect a decreasing in right ventricular function earlier. The value of right ventricular global longitudinal strain (RVGLS) based on the location of the pacemaker lead between the apex and non-apex was currently unknown, although the placement of the correct pacemaker lead location was very important for evaluating right ventricular dysfunction to prevent right heart failure. This study aims to determined the comparison of RVGLS between pacemaker lead position in patients with permanent pacemaker. Methods: This study was a nested case-control study to assess the comparison of RVGLS between pacemaker lead position in patients with permanent pacemaker, who were divided into the right ventricular apex group (RVA) and the non-right ventricular apex group (NRVA). This study used data from the pacemaker registry and medical records of patients who had undergone pacemaker implantation since June 2021. The shapiro-wilk normality test was performed before analyzing all numerical data, followed by an independent t-test or Mann-Whitney test to determine the differences between groups. Results: In this study, there were 38 patients with permanent pacemakers, consisting of 18 samples with RVA group and 20 samples with NRVA group. In this study, no significant differences were found in age, sex, diagnosis, comorbidities, therapy, pacemaker mode, baseline QRS duration, pacing burden, puncture site, and initial echocardiography between of two groups. There was a significant difference in paced QRS duration between the RVA and RVNA groups (160 + 20 ms vs 140 + 28 ms, p=0.024). Based on statistical analysis, there was a significant difference in the value of RVGLS in the RVA group compared to the RVNA group (-14.87+4.48% vs -18.40+3.21%, p=0.015). Conclusion: The position of the apex right ventricular lead resulted in a lower value of RVGLS compared to the position of the non-apex right ventricular lead.
A Case of Prenatal Diagnosis of Congenital Total AV Block on VSD and PDA with Ultrasound Yusrawati, Yusrawati; Wahdini, Nanda Tri; Rasyid, Hauda El; Riendra, Muhammad
Andalas Obstetrics And Gynecology Journal Vol. 5 No. 2 (2021)
Publisher : Fakultas Kedokteran Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/aoj.5.2.252-261.2021

Abstract

Objective : To report the diagnosis and management of congenital total AV block on VSD and PDA in pregnancy.Method : A case reportCase : A 37-year-old multiparous woman G4P3A0H2 24- 25 weeks of preterm pregnancy with fetal bradycardia, VSD, PDA with ultrasonography and CTG results was FHR 70 bpm. At 37- 38 weeks of pregnancy, termination of pregnancy was performed by cesarean delivery with preparation for complication of fetal AV block. A male baby was born with weight 2600 gram and APGAR score of 8/9. Immediate echocardiography result was situs solitus, VSD PM LR shunt, PDA LR shunt, good left ventricular function, left aortic arch and EF 74%. ECG result was sinus bradycardia, total AV block with junctional escape rhythm. Sternotomy and PPM implantation was performed by cardiothoracic surgeon three hours after the baby was born. Post PPM implantation, ECG results was HR 165 bpm and chest X- rays interpretation was cardiomegaly with plethora. Mother and baby came home in good condition on the 6th day of treatment. On the next baby’s control at 4.5 months obtained a weight of 5.4 kg with the echocardiography results was solitus, VSD PM LàR shunt, VSD muscular multiple 3 pieces LàR shunt, PDA LàR shunt, good right and left ventricular function, and left arch. The child got captopril 2x1.5 mg and planned for a 6-month repeat echocardiography.Conclusion : Congenital of total AV block on VSD and PDA is confirmed by prenatal diagnosis and preparation for comprehensive multidisciplinary management.Keywords: congenital total AV block, fetal bradycardia, fetal echocardiography, PPM, ultrasound
Co-Authors Andy, Marfri Fakhri, Muhamad Riendra, Muhammad Rizanda Machmud Wahdini, Nanda Tri Yanni, Mefri Yuliarni Syafrita Yusrawati Yusrawati