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All Journal Medical Journal of Indonesia Jurnal Biomedika dan Kesehatan Jurnal Ilmu Kesehatan Indonesia (JIKSI) Jurnal Kedokteran Meditek
Yanni, Mefri
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Biochemistry, Genetics & Molecular Biology Health Professions Immunology & microbiology Medicine & Pharmacology Neuroscience Public Health

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Hubungan Koping dengan Prestasi Akademik pada Mahasiswa Perantau Fakultas Kedokteran Universitas Andalas Wijaya, Harwin; Yanis, Amel; Yanni, Mefri; Murni, Arina Widya; Fasrini, Ulya Uti; Abdiana, Abdiana
Jurnal Ilmu Kesehatan Indonesia Vol. 5 No. 4 (2024): Desember 2024
Publisher : Fakultas Kedokteran, Universitas Andalas

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.25077/jikesi.v5i4.1206

Abstract

Latar Belakang: Koping merupakan suatu upaya kognitif atau perilaku untuk menghadapi tuntutan dari luar maupun dari dalam diri. Mahasiswa perantau sebagai individu yang pergi ke daerah lain dan dituntut untuk mampu menyesuaikan diri pada lingkungan baru, bila upaya penyesuaian tidak berjalan dengan baik dapat memunculkan stres atau bahkan beban mental yang dapat berdampak pada kemampuan mencapai prestasi akademik yang optimal. Dibutuhkan suatu mekanisme untuk menghadapi masalah tersebut, salah satunya adalah koping. Objektif: Tujuan dari penelitian ini adalah untuk mengetahui hubungan antara kemampuan koping dengan prestasi akademik pada mahasiswa perantau Program Studi Kedokteran Fakultas Kedokteran Universitas Andalas angkatan 2019. Metode: Penelitian ini merupakan penelitian analitik dengan pendekatan cross sectional yang menggunakan total sampling dengan didapatkan jumlah sampel sebanyak 96 orang yang merupakan mahasiswa perantau Program Studi Kedokteran Fakultas Kedokteran Universitas Andalas. Pengumpulan data responden diperoleh dari kuesioner dan data dianalisis menggunakan uji Fisher’s Exact Test. Hasil: Hasil analisis univariat menunjukkan mayoritas responden memiliki kemampuan koping adaptif (93,8%) dan minoritas responden memiliki kemampuan koping maladaptive. Kategori cukup memuaskan, memuaskan, dan sangat memuaskan (53,1%) merupakan kategori indeks prestasi yang terbanyak diperoleh responden dan minoritas responden memiliki kategori dengan pujian (46,9%). Kesimpulan: Tidak terdapat hubungan yang signifikan antara kemampuan koping dengan prestasi akademik (p=1).
Perbedaan Fungsi Sistolik Ventrikel Kanan antara Hipertensi Arteri Pulmonal dan Hipertensi Vena Pulmonal Rayhansyah, Vito; Yanni, Mefri; Irramah, Miftah; Hamdani, Rita; Revilla, Gusti; Linosefa, Linosefa
Jurnal Biomedika dan Kesehatan Vol 8 No 1 (2025)
Publisher : Fakultas Kedokteran Universitas Trisakti

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.18051/JBiomedKes.2025.v8.14-25

Abstract

Background Pulmonary arterial hypertension (PAH) and pulmonary venous hypertension (PVH) are both associated with increased right ventricular (RV) afterload, potentially leading to RV systolic dysfunction. Despite its prognostic value in predicting right heart failure (RHF), echocardiographic evaluation of RV function remains underutilized in the routine assessment of patients with PAH and PVH. Methods This study aims to evaluate differences in RV systolic function between PAH and PVH patients. A total of 116 patients (58 PAH and 58 PVH) were selected through consecutive sampling from medical records at RSUP Dr. M. Djamil Padang. Echocardiographic parameters were analyzed using appropriate statistical tests based on data distribution and type, including Chi-square, Fisher’s exact, and Mann-Whitney U tests. Results Significant differences were observed between PAH and PVH groups in terms of tricuspid regurgitation (TR) severity (p = 0.003), tricuspid annular plane systolic excursion (TAPSE) (p = 0.013), and tissue Doppler-derived systolic velocity of the tricuspid annulus (S′) (p = 0.001). No significant differences were found in ejection fraction (EF), systolic pulmonary artery pressure (sPAP), mean pulmonary artery pressure (mPAP), or TR velocity (TR Vmax). Overall, RV systolic function differed significantly between the PAH and PVH groups (p = 0.006). Conclusions The findings demonstrate a statistically significant difference in RV systolic function between patients with PAH and PVH. These results underscore the need for more comprehensive and routine echocardiographic evaluation of RV function in these populations to enhance risk stratification and management.
Double set up technique as a bailout of diagonal branch coronary perforation: a case report Syukri, Muhammad; Yanni, Mefri; Syafri, Masrul; Phalguna, Shindu; Firmansyah, Alles; Indah, Merlin Sari Mutma; Mahendra, Ivan; Zulkarnain, Hadi
Medical Journal of Indonesia Vol. 33 No. 1 (2024): March
Publisher : Faculty of Medicine Universitas Indonesia

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.13181/mji.cr.247266

Abstract

Coronary artery perforation is a rare but potentially life-threatening complication of percutaneous coronary intervention (PCI). A 55-year-old male with a history of implanted stent on the left main ostium to the proximal left circumflex artery (LCX) and distal right coronary artery, and chronic total occlusion (CTO) on ostium left anterior descending (LAD). PCI was performed using a stiff wire to cross the CTO body in LAD. We performed an injection and confirmed the presence of extravasation. We successfully managed to stop the bleeding by placing the tips of floppy wire that were cut into pieces. A drainage pathway was made through thoracotomy for pericardial effusion. Angiography showed persisting extravasation at the wire insertion site. We then made our own covered stent. We implanted on the osteal LAD until proximal LCX. Repeated angiography showed no contrast extravasated from the perforation site, and the patient was stabilized and discharged.
In Vitro Analysis of SCUBE1 Expression in Aortic Vascular Smooth Muscle Cells on Atherosclerosis Progression Rasya, Salsabila Faiha Wiendra; Ali, Hirowati; Yanni, Mefri; Rita , Rauza Sukma; Asri , Aswiyanti; Mahata , Liganda Endo; Putri , Biomechy Oktomalio; Yarni , Sisca Dwi
Jurnal Kedokteran Meditek Vol 32 No 3 (2026): MEI
Publisher : Fakultas Kedokteran Universitas Kristen Krida Wacana

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.36452/jkdoktmeditek.v32i3.4015

Abstract

Background:  Signal peptide-CUB-EGF domain-containing protein-1 (SCUBE1) is a platelet–endothelial glycoprotein implicated in thrombosis and vascular inflammation, and has been detected within atherosclerotic lesions. Whether vascular smooth muscle cells (VSMCs) upregulate SCUBE1 under inflammatory stimuli remains unclear. Objective:  To quantify SCUBE1 mRNA expression in rat aortic VSMCs following lipopolysaccharide (LPS) exposure in an organ-culture model of atherogenesis. Methods: This study aimed to analyze SCUBE1 expression in aortic VSMCs in atherosclerosis using real-time PCR. This study was a true experimental-post test control group design using organ culture. The aorta from six wistar rats were divided into two groups, consisting of five samples that were not induced with LPS and five samples exposed to LPS at a concentration of 10 µg/mL for 48 hours. Expression of the SCUBE1 gene was then analyzed using real-time PCR. The data was then processed using the dependent T-Test. Results: The result showed LPS increased SCUBE1 transcript levels compared with control (mean ± SD: 0.78 ± 0.22 vs 0.44 ± 0.35), representing a non-significant trend toward induction (p=0.07). These preliminary data are consistent with SCUBE1’s inducibility in inflammatory states and its presence in atherosclerotic tissue. Conclusion: This study revealed increased SCUBE1 gene expression in aortic VSMCs in the LPS-treated group. These data suggest that SCUBE1 has the potential to be a marker of endothelial dysfunction in atherosclerosis.
Co-Authors Abdiana Abdiana, Abdiana Amel Yanis Ariani, Novita Arina Widya Murni Asri , Aswiyanti Deddy Saputra Firmansyah, Alles Gunawan Gunawan Gusti Revilla Harahap, Hana Yulia Rahmi Hirowati Ali, Hirowati Indah, Merlin Sari Mutma Linosefa Linosefa Mahata , Liganda Endo Mahendra, Ivan Masrul Syafri Miftah Irramah Nabila, Sarah Phalguna, Shindu Putri , Biomechy Oktomalio Rasya, Salsabila Faiha Wiendra Rayhansyah, Vito Rita , Rauza Sukma Rita Hamdani Ulya Uti Fasrini Wijaya, Harwin Yarni , Sisca Dwi Zulkarnain, Hadi