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All Journal Jurnal Penelitian Pendidikan IPA (JPPIPA) International Journal of Science and Environment
Liena
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Agriculture, Biological Sciences & Forestry Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Education Materials Science & Nanotechnology Mathematics Physics

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The Use of Green Tea Extract (Camellia sinensis) Orally to Prevent Dyslipidemia in Female Rats (Rattus norvegicus) Fed A High-Fat Diet Lumbantobing, Christina J. R. Esmaralda; Damayanti, Risna; Liena
Jurnal Penelitian Pendidikan IPA Vol 9 No 12 (2023): December
Publisher : Postgraduate, University of Mataram

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.29303/jppipa.v9i12.6520

Abstract

One of the significant danger factors for cardiovascular disease and stroke is dyslipidemia. According to long-term prospective epidemiological research, coronary heart disease is less common in those with good lipid profiles who lead better lives. In this study, on a high-fat diet, female wistar rats (Rattus norvegicus) will be tested and analyzed to see if green tea extract (Camellia sinensis) can prevent dyslipidemia when given orally. Compared to a control group that received only distilled water, the trial group that received 5 milliliters of green tea extract (Camellia sinensis) had significantly lower total and LDL cholesterol levels and higher HDL cholesterol levels. This treatment was more effective in lowering cholesterol overall. The components found in green tea (Camellia sinensis), including tannins, steroids, alkaloids, saponins, and flavonoids, can induce this. When certain bioactive substances are off, the body can bring them back into normalcy. These results suggest that white wistar rats (Rattus norvegicus), given a high-fat diet, can benefit from green tea (Camellia sinensis) extract to avoid dyslipidemia. Your lipid profile can be improved by ingesting green tea extract. The primary polyphenol in tea, catechin, is responsible for this transformation. Therefore, the Camellia sinensis plant, from which green tea is made, is a valuable plant that can halt or slow the progression of several ailments, including hypertension, metabolic disorders, and cardiovascular disorders.
The Effect of Salam Leaf Ethanol Extract on the Histopathology of Doxorubicin-Induced Rats and its Effectiveness in Protecting the Heart Compared with Positive Control (Vitamin E) Dewi; Ermi Girsang; Ali Nafiah Nasution; Liena
International Journal of Science and Environment (IJSE) Vol. 1 No. 1 (2021): November 2021
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (131.179 KB) | DOI: 10.51601/ijse.v1i1.2

Abstract

This study aims to determine the effect of bay leaf ethanol extract on the histopathological picture of the kidneys of rats induced by doxorubicin. To determine the administration of bay leaf ethanol extract is more effective in protecting the heart than the positive control (Vitamin E). The bay leaves used were obtained from the Harjosari II Medan Amplas area of Medan city. The independent variable in this study was Salam Leaf Ethanol Extract, while the dependent variable was kidney histopathology. This research was conducted at the Pharmacology and Toxicology Laboratory of the Faculty of Pharmacy, University of North Sumatra. The results showed that the administration of vitamin E together with doxorubicin showed a better renal histopathological picture. Vitamin E as a basic antioxidant is able to reduce the damage caused by doxorubicin which is seen in the absence of widening in the Bowman capsule.
Co-Authors Ali Nafiah Nasution Damayanti, Risna Dewi Ermi Girsang Lumbantobing, Christina J. R. Esmaralda