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All Journal Indonesian Journal of Cardiology Heart Science Journal International Journal Of Science, Technology & Management (IJSTM) International Journal of Science and Environment
Ali Nafiah Nasution
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Aerospace Engineering Agriculture, Biological Sciences & Forestry Automotive Engineering Biochemistry, Genetics & Molecular Biology Chemical Engineering, Chemistry & Bioengineering Chemistry Civil Engineering, Building, Construction & Architecture Computer Science & IT Control & Systems Engineering Decision Sciences, Operations Research & Management Earth & Planetary Sciences Education Electrical & Electronics Engineering Energy Engineering Health Professions Immunology & microbiology Industrial & Manufacturing Engineering Mathematics Mechanical Engineering Medicine & Pharmacology Physics Transportation

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Nilai Skor CHA2DS2-VAS-HSF Sebagai Prediktor Kejadian Nefropati Yang Diinduksi Kontras Pada Pasien Sindroma Koroner Akut Yang Menjalani Prosedur Intervensi Koroner Perkutan Herman William Parlindungan; Refli Hasan; Cut Aryla Andra; Nizam Zikri Akbar; Ali Nafiah Nasution; Harris Hasan; Zainal Safri; Anggia C Lubis; Bertha Gabriella Napitupulu
Jurnal Kardiologi Indonesia Vol 39 No 2 (2018): Indonesian Journal of Cardiology: April-June 2018
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.v39i2.766

Abstract

Background: Contrast-Induced Nephropathy (CIN) is a serious problem that can be found in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). The development of CIN in hospitalized patients even with coronary revascularization can immediately increase morbidity and mortality both during treatment and long-term outcomes. In a recent study, a CHA2DS2-VASC-HSF score was reported to predict coronary artery severity and major cardiovascular events (MACE) as well as CIN in AMI patients without atrial fibrillation. The purpose of this study was to investigate the CHA2DS2-VASC score as a predictor of CIN in AMI patients undergoing PCI procedures. Methods: This study was an ambispective cohort study of 53 AMI patients who were treated at cardiac care and underwent PCI procedures. The CHA2DS2-VASC-HSF score was calculated for each patient. From this study found 14 cases (26.4%) with a total CIN prevalence of 16.83%. CIN is defined as an increase in serum creatinine> 0.5 mg / dL or an increase in serum creatinine> 25% from baseline within 24 hours post PCI. Results: Through the analysis of the ROC curve, we established the CHA2DS2- VASC-HSF score cut point> 5 as a predictor of CIN with a sensitivity of 78.57% and specificity of 66.6 %% (AUC 0.818, 95%: CI 3.018-6.142, p <0.001). By getting the equation from the linear regression assessment we also found the probability of the occurrence of CIN in accordance with the CHA2DS2-VASC-HSF score. Conclusion: CHA2DS2-VASC score has a positive correlation with CIN. Therefore, this score can be used as a simple scoring system and can predict the incidence of CIN in AMI patients undergoing PCI procedures.
A Significant Addition of Left Ventricular Fractional Shortening to Ejection Fraction correlated with Global Longitudinal Strain Value in Predicting Major Acute Cardiovascular Event in patients with Acute Coronary Syndrome Bertha Gabriela Napitupulu; Harris Hasan; Nizam Z Akbar; Andre Pasha Ketaren; Zainal Zafri; Ali Nafiah Nasution
Jurnal Kardiologi Indonesia Vol 41 No 4 (2020): Indonesian Journal of Cardiology: October - December 2020
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1069

Abstract

Background: Global longitudinal strain (GLS) was a proven predictor of systolic function improvement and myocardial remodeling after acute coronary syndrome (ACS) for a residual left ventricular function defined their prognosis. However, not all echocardiography devices are equipped by speckle tracking (STE) as compare to the availability of M-mode modality which capable on assessing fractional shortening (FS) instead. Methods: This study evaluated clinical and echocardiography parameters on myocardial infarction (MI) and non-MI ACS patients. Clinical outcome was defined as composite major acute cardiovascular event (MACE) on 6 months of follow up. Results: Over 145 patients, GLS>-9.4% was found to be an independent predictor of MACE despite of troponin, age, ejection fraction (EF), prior reperfusion and infarct location [(HR 5.89 (1.82-16.51)]. There is negative correlation between FS and GLS (Spearman r -0,717; p<0,01). By using logistic regression analyses, it was found that the addition of FS<25% to biplane Simpson EF<50% could be useful to rule in the presence of GLS>-9.4% (AUC 0.831). Conclusion: GLS had a prognostic value in patients with ACS. Left ventricular conventional M-mode FS in addition to Simpson EF were well correlated with GLS as well they can be considered as an alternative in predicting the incident of MACE in patient with ACS. Keywords: global longitudinal strain, prognostic, fractional shortening, acute coronary syndrome
Testing Of The Nephroprotective Effectiveness Of Sail Leaf (Syzygium Polyanthum (Wight.)Walp.) In DoxorubisinInduced Male Wistar Rat Dewi; Ali Nafiah Nasution; Ermi Girsang
International Journal of Science, Technology & Management Vol. 2 No. 6 (2021): November 2021
Publisher : Publisher Cv. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.46729/ijstm.v2i6.372

Abstract

Cancer is one of the leading noncommunicable diseases leading to death worldwide. Cancer treatment has progressed but has side effects including nephrotoxic effects. The toxicity of doksorubisin has been widely known which is likely to be chained by the metabolic conversion of doxorubicin to doxorubicinol. The main mechanism of doxorubicinol toxicity occurs due to its interaction with iron and the formation of ROS that damages cell macromolecules. One of the plants that are widely used by the community to deal with various diseases and prevention is bay leaves. Bay leaves contain secondary metabolites that are antioxidant in nature. Antioxidants are needed to protect the body's cells from oxidative damage, preventing various degenerative diseases such as cancer, cardiovascular disease. The study aimed to determine the content of nephroprotective EEDS chemical compounds in phytochemical screening, EEDS characterization and EEDS nephroprotective activity in doxorubicin-induced mice based on uric acid, ureum and creatine levels. The study was experimentally laboratory using mice as test animals. The treatment group consisted of CMC-Na 0.5%, Nature E, EEDS doses of 100 mg/kgBB, 300 mg/kgBB and 500 mg/kgBB followed by administration of doxorubicin. The results showed phytochemicalally EEDS contains chemical compounds that are nephroprotective namely flavonoids, steroids / triterpenoids, saponins . EEDS has a water soluble sari content value of 21.64%, total ash content of 1.79%, water content of 9.98%. Ethanol soluble juice levels were 45.38% and acid insoluble ash levels were 0.39%. EEDS doses of 100 mg/kgBB, 300 mg/kgBB and 500 mg/kgBB can lower uric acid, ureum and cretinine levels and can picture the histopathology of doxorubicin-induced mouse kidneys with an effective dose of 500 mg/kgBB. It can be concluded that ethanol extract of bay leaves has nephroprotective activity.
Quality of life assessment in patients after permanent pacemaker implantation at Haji Adam Malik Hospital Medan Khairunnisah, Dina; Ali Nafiah Nasution; Refli Hasan; Nizam Zikri Akbar; Anggia Chairuddin Lubis; Abdul Halim Raynaldo
Heart Science Journal Vol. 6 No. 3 (2025): Advancements in Cardiac Imaging : Unlocking New Perspectives on the Heart Visua
Publisher : Universitas Brawijaya

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.21776/ub.hsj.2025.006.03.15

Abstract

Background: PPM implantation is used to send electrical impulses to the heart muscle to correct heart rhythm disturbances also known as cardiac arrythmia. Assessing the patient's quality of life after a PPM implantation is crucial for predicting the therapy's effectiveness and success. Objectives: This study aims to assess the quality of life of patients following pacemaker implantation by using the SF-36 questionnaire. Methods: A cross-sectional study conducted from January 2021 to July 2023 on 60 outpatients with a minimum duration of PPM implantation of 6 months in the cardiology department of H. Adam Malik Hospital Medan. Patient’s quality of life was assessed based on the SF-36 questionnaire. Subjects then were grouped based on age, gender, PPM duration and location, as well as other echocardiographic parameters that may affect patient’s quality of life after PPM implantation. Results: There were 60 patients included in this study. Majority of patients were male (56.7%) with an average age of 67.98 ± 10.95 years old and most patients had comorbidities (81.7%). The majority of patients (93.3%) had a single-chamber permanent pacemaker implanted, with 68.3% of these devices’ ventricular leads positioned in the non-apical segment of the heart.  After assessing the quality of life, we found there’s a relationship between age, gender, and PPM lead locations with nearly all SF-36 domains (p<0.05). Additionally, there was a significant association between comorbidities and SF-36 scores, including physical function, physical limitations, and emotional limitations (p<0.05). There was a significant association between ejection fraction and SF-36 scores, including physical function, role limitations due to physical health problems, vitality, social function, bodily pain and general health. However, no relationship was found between IMT and PPM implantation duration with SF-36 scores (p>0.05). Conclusion: We identified a relationship between age, gender, comorbidities, PPM lead location, and ventricular ejection fraction with the quality of life of patients following PPM implantation
The Effect of Salam Leaf Ethanol Extract on the Histopathology of Doxorubicin-Induced Rats and its Effectiveness in Protecting the Heart Compared with Positive Control (Vitamin E) Dewi; Ermi Girsang; Ali Nafiah Nasution; Liena
International Journal of Science and Environment (IJSE) Vol. 1 No. 1 (2021): November 2021
Publisher : CV. Inara

Show Abstract | Download Original | Original Source | Check in Google Scholar | Full PDF (131.179 KB) | DOI: 10.51601/ijse.v1i1.2

Abstract

This study aims to determine the effect of bay leaf ethanol extract on the histopathological picture of the kidneys of rats induced by doxorubicin. To determine the administration of bay leaf ethanol extract is more effective in protecting the heart than the positive control (Vitamin E). The bay leaves used were obtained from the Harjosari II Medan Amplas area of Medan city. The independent variable in this study was Salam Leaf Ethanol Extract, while the dependent variable was kidney histopathology. This research was conducted at the Pharmacology and Toxicology Laboratory of the Faculty of Pharmacy, University of North Sumatra. The results showed that the administration of vitamin E together with doxorubicin showed a better renal histopathological picture. Vitamin E as a basic antioxidant is able to reduce the damage caused by doxorubicin which is seen in the absence of widening in the Bowman capsule.
Co-Authors Abdul Halim Raynaldo Andre Pasha Ketaren Anggia C Lubis Bertha Gabriela Napitupulu Bertha Gabriella Napitupulu Cut Aryla Andra Dewi Ermi Girsang Harris Hasan Hasan, Refli Herman William Parlindungan Khairunnisah, Dina Liena Lubis, Anggia Chairuddin Nizam Z Akbar Nizam Zikri Akbar Zainal Safri Zainal Zafri