Article Per Year (5 Year)
p-Index From 2020 - 2025
0.983
P-Index
This Author published in this journals
All Journal International Journal of Integrated Health Sciences Indonesian Journal of Cardiology Indonesian Journal of Obstetrics & Gynecology Science
Cool, Charlotte Johanna
Unknown Affiliation
Health Professions Medicine & Pharmacology Public Health

Published : 5 Documents Claim Missing Document
Claim Missing Document
Check
Articles

Found 5 Documents
Search

 1 
Novel Echocardiographic Parameter Assessing Pulmonary Vascular Resistance in Patient with Acyanotic Congenital Heart Disease Natadikarta, Muhammad Raihan Ramadhan; Cool, Charlotte Johanna; Khalid, Achmad Fitrah; Sukmadi, Norman; Martha, Januar Wibawa
Jurnal Kardiologi Indonesia Vol 45 No 4 (2024): Online First - Indonesian Journal of Cardiology April-June 2021
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1790

Abstract

Background Pulmonary vascular resistance (PVR) is an important variable in management of acyanotic congenital heart disease. Right heart catheterization (RHC) using impedance catheter remains gold standard for pulmonary vascular resistance (PVR) measurement. The ratio of peak tricuspid regurgitant velocity to the right ventricular outflow tract time-velocity integral (TRVmax/RVOTVTI) was presented as a reliable non-invasive method of estimating PVR. Recently, right ventricular 2-dimensional speckle tracking strain (RVGLS) was proven as a new promising parameter to evaluate PVR. This study performed to examine whether this new non-invasive variable ratio (TRVmax/RVGLS) provides clinically reliable method to determine pulmonary vascular resistance (PVR) obtained by echocardiography. Methods Right-heart catheterization and echocardiographic examination were performed in 56 patients with congenital heart disease. The ratio of TRVmax/RVOTVTI and TRVmax/RVGLS analysis performed using receiver-operating characteristic curve analysis, a cutoff value for the ratio was generated to determine PVR more than 5 WU. Results A TRVmax/RVOTVTI cutoff value of 0.21 provided a sensitivity of 77.1% and a specificity of 81% (CI 81% to 97.5%) and TRVmax/RVGLS cutoff value of -23.16 provided sensitivity of 74.3% and a specificity of 90.5% to determine PVR > 5 WU (CI 79.6% to 98.2%). Conclusions The echocardiography parameter (TRVmax/RVGLS) could serve as a dependable noninvasive method to predict PVR greater than 5 WU in acyanotic congenital heart disease patients.
Mexiletine in the treatment of LQT2, LQT3, and acquired LQTS: a meta-analysis Ihsan, Dhiya; Iqbal, Mohammad; Cool, Charlotte Johanna; Achmad, Chaerul; Pramudyo, Miftah; Prameswari, Hawani Sasmaya; Akbar, Mohammad Rizki
Jurnal Kardiologi Indonesia Vol 46 No 2 (2025): April - June, 2025
Publisher : The Indonesian Heart Association

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.30701/ijc.1835

Abstract

Background: High mortality in patients with Long QT Syndrome (LQTS) can be reduced with proper treatment. Gene-specific therapy is crucial, as many treatments are not equally effective across different LQTS types. While mexiletine has been established in the treatment of LQT3, its use in other types of LQT need further evaluation. Methods: A meta-analysis was conducted using systematic electronic searches of PubMed, Embase, and Cochrane Library. We assessed QTc reduction and cardiac events after Mexiletine treatment. Inclusion criteria: any study with no language restriction that diagnoses any type of LQTS, uses mexiletine treatment, and provides QTc comparison before and after treatment. Animal studies were excluded. The NIH Study Quality Assessment Tools and Newcastle-Ottawa Scale were used to evaluate bias. Data were analyzed using Review Manager 5.4 and MedCalc software Results: Nine studies (n=281) were included. Mexiletine reduced QTc by -64ms (mean difference [MD], -64.22; 95% confidence interval [CI] -76.13 to -52.30; p<.001; I2 60%). Sensitivity and subanalyses showed consistent efficacy. In five studies (n=76), the number of patient with high-risk QTc (>500ms) significantly decreased (Risk Ratio [RR], 0.38; 95% CI 0.26-0.55; p<.001). Five studies (n=141) showed a significant reduction in cardiac events (RR, 0.25; 95% CI 0.14-0.44; p<.001). Two studies reported gastrointestinal (GI) problems and vertigo as side effects of mexiletine treatment. Conclusion: Mexiletine significantly reduces QTc and cardiac events in LQT2, LQT3, and aLQT patients. Mexiletine also significantly reduces the number of Long QT patients with high-risk QTc Funding: No external funding was received for this study Registration: CRD420250652574
Predictors of In-Hospital Mortality in Patients with Infective Endocarditis: A Single-Center Study Hanim, Haifany Fauziyah; Ikhsani, Rizkania; Yudharaputri, Digita Natarina; Cool, Charlotte Johanna; Hasan, Melawati
International Journal of Integrated Health Sciences Vol 13, No 1 (2025)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v13n1.3753

Abstract

Background: Infective endocarditis remains a life-threatening condition with high in-hospital mortality, necessitating identification of predictive clinical factors.Objective: To identify predictors of in-hospital mortality in infective endocarditis (IE) patients.Methods: This single-center retrospective study included 88 patients with IE aged ≥ 18 years treated at Dr. Hasan Sadikin General Hospital, Bandung, Indonesia, between September 2019 and May 2023. During hospitalization, data regarding clinical characteristics, blood cultures, and clinical outcomes were assessed to identify the predictors of in-hospital mortality. Data were analyzed using chi-square and binary logistic regression.Results: Among 88 patients with IE, the majority were male (56.8%) and aged < 60 years old (78%). More than two-thirds of patients had valvular heart disease. During treatment, 22 patients (25%) underwent cardiac surgery, and the total in-hospital mortality rate was 35.2%. Although not statistically significant, in-hospital mortality rate was lower in operated patients (22.7% vs 39.4%). In multivariate analysis, septic shock was the only significant predictor of in-hospital mortality (OR 40, 95% CI: 4.7–339, p 0.001)Conclusion: Septic shock is a strong predictor of in-hospital mortality among patients with infective endocarditis. Invasive management by cardiac surgery does not significantly decrease the mortality risk.
Profile and Pregnancy Outcome in Preeclampsia with and Without Cardiac Abnormalities Complication Aqilah, Nurjihan Syarifah; Pribadi, Adhi; Cool, Charlotte Johanna; Aziz, Muhammad Alamsyah; Pramudyo, Miftah; Astuti, Astri; Putra, Ridwan Abdullah
Indonesian Journal of Obstetrics & Gynecology Science Volume 7 Nomor 3 November 2024
Publisher : Dep/SMF Obstetri & Ginekologi Fakultas Kedokteran Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.24198/obgynia.v7i3.742

Abstract

Introduction: This study was conducted to determine the profile of maternal characteristics and outcomes, as well as neonatal outcomes of mothers giving birth with preeclampsia and complications of cardiac abnormalities compare to preeclampsia without complications of cardiac abnormalities.Methods: This study used a descriptive cross-sectional research method with purposive sampling.Results: Out of 78 samples, there were 10 pregnant women with cardiac abnormalities. The predominant age is in the 18 - 35 years range at 51 (65.4%) samples. Comorbidities found were eclampsia 8 (10.3%) and HELLP syndrome 3 (3.8%). There was no maternal mortality. The major method of delivery was perabdominal in preeclampsia with cardiac abnormalities 10(100.0%). The neonatal outcome obtained APGAR scores of 7-10 as many as 57 (73.1%) babies, 8 (10.2%) babies with score 4-6, and 13 (16.7%) babies with score 0-3. There were 16 (20.5%) babies born with SGA, 58 (74.4%) with AGA, and 4 (5.1%) with LGA. Most neonatal born with normal APGAR score (58 babies or 74.4%). In the PE group with heart defects, there was 1 (10.0%) baby with severe asphyxia as in stillbirth. While in preeclampsia without cardiac abnormalities 11 (16.2%) babies were born with severe asphyxia and 8 (10.2%) stillbirths.Conclusion: The maternal outcomes were (1) comorbidities of eclampsia and HELLP syndrome, (2) the majority of delivery methods being caesarean section., and in neonatal outcomes, most babies were born with normal APGAR score and appropriate gestational age (AGA).Profil dan Luaran Kehamilan pada Preeklamsia dengan dan Tanpa Komplikasi Kelainan JantungAbstrakPendahuluan: Penelitian ini dilakukan untuk mengetahui profil karakteristik dan luaran maternal, serta luaran neonatal ibu melahirkan dengan preeklamsia dengan komplikasi kelainan jantung dan preeklamsia tanpa komplikasi kelainan jantung.Metode: Penelitian ini menggunakan metode penelitian deskriptif potong lintang dan pengambilan sampel penelitian purposif.Hasil: Dari 78 sampel, didapatkan 10 ibu hamil dengan kelainan jantung. Usia paling banyak ada pada rentang usia 18 - 35 tahun 51(65.4%) sampel. Penyakit pernyerta didapatkan eklamsia 8(10.3%) dan sindrom HELLP 3(3.8%). Tidak ditemukan kematian ibu. Metode persalinan terbanyak yaitu perabdominal pada PE dengan kelainan jantung 10(100.0%). Hasil luaran neonatal kelahiran bayi tunggal, didapatkan skor APGAR 7-10 sebanyak 57(73.1%) bayi, 8(10.2%) bayi dengan skor 4-6, dan 13(16.7%) bayi dengan skor 0-3. Terdapat 16(20.5%) bayi lahir dengan SGA, 58(74.4%) dengan AGA, dan 4(5.1%) dengan LGA. Hasil luaran neonatal terbanyak dengan kondisi APGAR normal (58 bayi atau 74.4%). Pada kelompok PE dengan kelainan jantung ditemukan 1(10.0%) bayi dengan luaran asfiksia berat begitu pun dengan stillbirth. Sedangkan pada PE tanpa kelainan jantung sebanyak 11(16.2%) lahir dengan asfiksia berat dan 8(10.2%) stillbirth.Kesimpulan: Luaran kehamilan yang ditemukan yaitu (1) penyakit penyerta berupa eklamsia dan sindrom HELLP, (2) metode persalinan terbanyak yaitu caesarean section, dan hasil luaran neonatal terbanyak adalah dengan kondisi APGAR normal dan AGA.Kata kunci: Luaran kehamilan; Luaran neonatal; Preeklamsia dengan kelainan jantung
Unexpected Infective Endocarditis in Corrected Congenital Heart Disease: A Case Report Cool, Charlotte Johanna; Serulina, Rachmi; Saboe, Aninka
International Journal of Integrated Health Sciences Vol 10, No 1 (2022)
Publisher : Faculty of Medicine Universitas Padjadjaran

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.15850/ijihs.v10n1.2166

Abstract

Objective: To describe patients with corrected Congenital Heart Disease (CHD) who experienced Infective Endocarditis (IE).Methods: Two cases of IE were observed in 2019. The first case involved a 36-year-old woman with previous percutaneous transcatheter perimembranous ventricular septal defect (VSD) closure four months before admission. Echocardiography showed vegetation at noncoronary cusps of the aortic valve. Patient received antibiotics for six weeks and underwent surgery for evacuation of vegetation and device, along with VSD closure with a cardiovascular patch (Gore-tex). The second case involved a 43-year-old woman with a history of surgical closure in secundum atrial septal defect (ASD) by pericardial patch two months before admission. Echocardiography showed vegetation at the tricuspid valve. Patient received antibiotics for four weeks and planned for surgery to evacuate vegetation.  Results: IE is one of the major complications in CHD, whether uncorrected, treated, or corrected. The risk of IE increased with an invasive procedure. Post closure IE is rare. Poor dental hygiene and immunocompromised also increased patient's risk to be exposed to IE as shown in the first patient who had dental caries and the second patient who was on methylprednisolone for post-surgical pericardial effusion treatment. Conclusion: The risk of IE increases with invasive procedures in CHD patients. Although the incidence of IE is quite rare, its possibility should become of a serious concern among physicians.
Co-Authors Adhi Pribadi Akbar, Mohammad Rizki Aqilah, Nurjihan Syarifah ASTRI ASTUTI Aziz, Muhammad Alamsyah Chaerul Achmad Daniel Happy Putra Hanim, Haifany Fauziyah Hasan, Melawati Ihsan, Dhiya Ikhsani, Rizkania Januar Wibawa Martha Khalid, Achmad Fitrah Natadikarta, Muhammad Raihan Ramadhan Prameswari, Hawani Sasmaya Pramudyo, Miftah Putra, Ridwan Abdullah Saboe, Aninka Serulina, Rachmi Sukmadi, Norman Yudharaputri, Digita Natarina