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All Journal Journal of Electrical, Electronic, Information, and Communication Technology (JEEICT) Cermin Dunia Kedokteran
Sari, Andayani Yuwana
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Computer Science & IT Control & Systems Engineering Electrical & Electronics Engineering Health Professions

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LGR-5 sebagai Biomarker pada Kanker Kolorektal: Tinjauan Sistematis Fitur Klinikopatologis dan Nilai Prognostik: Analisis Asaduddin, Aiman Hilmi; Farhania, Roisya Nur; Imani, Namira Putri; Pramaesti, Cindy Ayudia; Sari, Andayani Yuwana
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1282

Abstract

Colorectal cancer (CRC) had the third highest cancer incidence worldwide. Recent researches are targeting specific gene expression as CRC marker. Leucine rich repeat-containing G-protein coupled receptor 5 (LGR5) is one of the genes that regulate tumor metastasis and growth. The aim of this study is to explain the correlation between LGR5, clinical pathology, and prognosis of CRC. This systematic review was arranged using PRISMA for eligible cohort studies and evaluated using Newcastle-Ottawa scale. From 63 articles, 6 articles were selected as eligible articles for data extraction and evaluation. Based on the studies, LGR5 positivity was positively associated with histopathological characteristics, TNM staging, and vascular invasion. Besides, LGR5 expressions in those studies were high and could be positively detected by this marker. LGR5 regulates Wnt/β-catenin signaling pathway promotion in normal colon stem cell. Methylation of Wnt target gene promoter is potent predictor to CRC recurrence thus the expression of LGR5 can be used as CRC marker. LGR5 plays a role as pro-oncogenic factor in colorectal carcinogenesis via prostaglandin E2 and Epidermal Growth Factor signaling. LGR5 induction also could increase cancer cells chemoresistant ability. Thus, LGR5 could determine prognosis of CRC patient and were related to certain clinicopathological features and tumor progressions.
Design of Hearing Aid and Speech Device for People Hearing Dissorders Adriyanto, Feri; Santoso, Henry Probo; Sari, Andayani Yuwana; Suroya, Rizki Misbakhus
Journal of Electrical, Electronic, Information, and Communication Technology Vol 4, No 1 (2022): JOURNAL OF ELECTRICAL, ELECTRONIC, INFORMATION, AND COMMUNICATION TECHNOLOGY
Publisher : Universitas Sebelas Maret (UNS)

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.20961/jeeict.4.1.61163

Abstract

Deafness is a condition in which a person cannot hear due to a disturbance in his hearing organs. In communicating, most of the deaf sufferers only receive hearing aids. WHO (World Health Organization) initiated the Sound of Hearing 2030 by preventing hearing loss by 50% in 2015 and 90% in 2030. The main objective of Sound of Hearing is to develop a comprehensive, inclusive, and sustainable ear care program. Various studies on tools for deafness have been developed. However, this tool is only used to help deaf hearing but not to help speech learning (learn to speak). Thus we need hearing aids and speech learning tools for the deaf. This tool can be a government program, namely supporting a diffable-friendly Indonesia. The tool is designed like a headband, where the headband is composed of a row of vibrating modules that will be connected to the Google Assistant on a smartphone, so that any sound received by the Google Assistant will be sent to the tool to be converted into a vibration pattern. It is from these vibration patterns that a deaf person will get experience in recognizing sounds and learn to speak based on the vibration patterns that are formed. With the design of this tool, it hoped that it can help deaf people and get support from the community and government to create a diffable-friendly Indonesia. 
Co-Authors Adriyanto, Feri Asaduddin, Aiman Hilmi Farhania, Roisya Nur Imani, Namira Putri Pramaesti, Cindy Ayudia Santoso, Henry Probo Suroya, Rizki Misbakhus