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All Journal Pharmaceutical Sciences and Research (PSR) Cermin Dunia Kedokteran
Imani, Namira Putri
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Health Professions

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Evaluation of Anti-VEGF and Pan-Retinal Photocoagulation Laser Therapies in Proliferative Diabetic Retinopathy Patients: A Systematic Review Indrakila, Senyum; Imani, Namira Putri; Asaduddin, Aiman Hilmi; Karima, Muzakiya Lailatul; Widjaja, Lygia Angelica
Pharmaceutical Sciences and Research Vol. 10, No. 2
Publisher : UI Scholars Hub

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Abstract

Diabetic retinopathy is a complication of diabetes that is one of the top five causes of blindness in those over 50. The standard treatment is pan-retinal photocoagulation, which is effective but has established side effects. Anti-vascular endothelial growth factor (anti-VEGF) therapy becomes an alternative to avoid the side effects caused by laser therapy. This systematic review aims to know the effectiveness of anti-VEGF therapy compared to the pan-retinal photocoagulation laser therapy in patients with proliferative diabetic retinopathy. This review was carried out using a systematic review checklist on PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses). The articles reviewed were randomized controlled trial articles that met the inclusion and exclusion criteria. Based on inclusion and exclusion criteria, six articles were selected from a total of 215. Patients who received anti-VEGF medication had better visual acuity (positive values), whereas patients who received laser therapy had poorer visual acuity (negative values). Those results are because the laser directs light towards the retina, damaging photoreceptors and retinal cells as well as reducing visual acuity. On the contrary, anti-VEGF prevents damage to retinal endothelial cells and blood leaks in the vitreous by decreasing VEGF expression and thus resulting in improved visual acuity. Anti-VEGF proved to be a more practical alternative therapy in improving visual acuity than pan-retinal photocoagulation for patients with proliferative diabetic retinopathy.
LGR-5 sebagai Biomarker pada Kanker Kolorektal: Tinjauan Sistematis Fitur Klinikopatologis dan Nilai Prognostik: Analisis Asaduddin, Aiman Hilmi; Farhania, Roisya Nur; Imani, Namira Putri; Pramaesti, Cindy Ayudia; Sari, Andayani Yuwana
Cermin Dunia Kedokteran Vol 52 No 3 (2025): Oftalmologi dan Dermatologi
Publisher : PT Kalbe Farma Tbk.

Show Abstract | Download Original | Original Source | Check in Google Scholar | DOI: 10.55175/cdk.v52i3.1282

Abstract

Colorectal cancer (CRC) had the third highest cancer incidence worldwide. Recent researches are targeting specific gene expression as CRC marker. Leucine rich repeat-containing G-protein coupled receptor 5 (LGR5) is one of the genes that regulate tumor metastasis and growth. The aim of this study is to explain the correlation between LGR5, clinical pathology, and prognosis of CRC. This systematic review was arranged using PRISMA for eligible cohort studies and evaluated using Newcastle-Ottawa scale. From 63 articles, 6 articles were selected as eligible articles for data extraction and evaluation. Based on the studies, LGR5 positivity was positively associated with histopathological characteristics, TNM staging, and vascular invasion. Besides, LGR5 expressions in those studies were high and could be positively detected by this marker. LGR5 regulates Wnt/β-catenin signaling pathway promotion in normal colon stem cell. Methylation of Wnt target gene promoter is potent predictor to CRC recurrence thus the expression of LGR5 can be used as CRC marker. LGR5 plays a role as pro-oncogenic factor in colorectal carcinogenesis via prostaglandin E2 and Epidermal Growth Factor signaling. LGR5 induction also could increase cancer cells chemoresistant ability. Thus, LGR5 could determine prognosis of CRC patient and were related to certain clinicopathological features and tumor progressions.
Co-Authors Asaduddin, Aiman Hilmi Farhania, Roisya Nur Karima, Muzakiya Lailatul Pramaesti, Cindy Ayudia Sari, Andayani Yuwana Senyum Indrakila Widjaja, Lygia Angelica